BLTR1 Is Decreased in Steroid Resistant Pro-Inflammatory CD28nullCD8+ T Lymphocytes in Patients with COPD—The Spillover Hypothesis Explained?

BLTR1 Is Decreased in Steroid Resistant Pro-Inflammatory CD28nullCD8+ T Lymphocytes in Patients with COPD—The Spillover Hypothesis Explained?

Introduction: Pro-inflammatory CD8+ T cells are increased in the lungs and also in the peripheral circulation of both smokers and chronic obstructive pulmonary disease (COPD) patients. The reason for this is unclear but has been described as a spillover from cells in the lungs that may cause the sys...

Full description

Bibliographic Details
Main Authors:	Greg Hodge, Hubertus Jersmann, Mark Holmes, Patrick Asare, Eugene Roscioli, Paul N. Reynolds, Sandra Hodge
Format:	Article
Language:	English
Published:	MDPI AG 2023-09-01
Series:	Biology
Subjects:	COPD BLTR1 steroid resistant pro-inflammatory lymphocytes
Online Access:	https://www.mdpi.com/2079-7737/12/9/1261

Similar Items

Steroid resistant CD8+ CD28null NKT-like pro-inflammatory cytotoxic cells in chronic obstructive pulmonary disease (COPD)
by: Greg Hodge, et al.
Published: (2016-12-01)

Lymphocyte senescence in COPD is associated with decreased sirtuin 1 expression in steroid resistant pro-inflammatory lymphocytes
by: Greg Hodge, et al.
Published: (2020-04-01)

Potential Link between the Sphingosine-1-Phosphate (S1P) System and Defective Alveolar Macrophage Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD).
by: Jameel Barnawi, et al.
Published: (2015-01-01)

Airway epithelial cells exposed to wildfire smoke extract exhibit dysregulated autophagy and barrier dysfunction consistent with COPD
by: Eugene Roscioli, et al.
Published: (2018-11-01)

Inhibition of LC3-associated phagocytosis in COPD and in response to cigarette smoke
by: Patrick F. Asare, et al.
Published: (2021-10-01)

Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD.
by: Hai B Tran, et al.
Published: (2017-01-01)

Defective lung macrophage function in lung cancer ± chronic obstructive pulmonary disease (COPD/emphysema)-mediated by cancer cell production of PGE2?
by: Francis C Dehle, et al.
Published: (2013-01-01)

The role of oxidised self-lipids and alveolar macrophage CD1b expression in COPD
by: Miranda P. Ween, et al.
Published: (2021-02-01)

Zinc and zinc transporters in macrophages and their roles in efferocytosis in COPD.
by: Rhys Hamon, et al.
Published: (2014-01-01)

Oxidative stress decreases functional airway mannose binding lectin in COPD.
by: Hai B Tran, et al.
Published: (2014-01-01)

COPD-Related Modification to the Airway Epithelium Permits Intracellular Residence of Nontypeable Haemophilus influenzae and May Be Potentiated by Macrolide Arrest of Autophagy
by: Poh WP, et al.
Published: (2020-06-01)

Null hypothesis test for anomaly detection
by: Jernej F. Kamenik, et al.
Published: (2023-05-01)

AIM2 nuclear exit and inflammasome activation in chronic obstructive pulmonary disease and response to cigarette smoke
by: Hai B. Tran, et al.
Published: (2021-05-01)

BLTR1 in Monocytes Emerges as a Therapeutic Target For Vascular Inflammation With a Subsequent Intimal Hyperplasia in a Murine Wire-Injured Femoral Artery
by: Seung E. Baek, et al.
Published: (2018-08-01)

Antigen-dependent and antigen-independent pathways modulate CD4+CD28null T-cells during atherosclerosis.
by: Ammirati, E, et al.
Published: (2012)

CD4+CD25highCD127- regulatory T-cells in COPD: smoke and drugs effect
by: Alessandra Chiappori, et al.
Published: (2016-01-01)

Clocks and chronogeometry: rotating spacetimes and the relativistic null hypothesis
by: Menon, T, et al.
Published: (2018)

Empirically testing Keynesian defense burden hypothesis, nonlinear hypothesis, and spillover hypothesis: Evidence from Asian countries
by: Qurat Ul AIN, et al.
Published: (2019-03-01)

Role of Steroids in COPD
by: Vishnu Sharma
Published: (2002-04-01)

Evaluating the Roles of sCD14 and sCD14-ST in Diagnosing COPD and Predicting an Acute Exacerbation of COPD
by: Rui Zhang, et al.
Published: (2022-06-01)

Absence of Staphylococcus aureus in Wild Populations of Fish Supports a Spillover Hypothesis
by: Marta Matuszewska, et al.
Published: (2023-08-01)

Ultrastructure and function studies in CD38 null mice reveal a role for CD38 in anterior pituitary somatotrophs
by: Patel, S, et al.
Published: (2009)

COPD in nonsmokers: the biomass hypothesis--to be or not to be?
by: Gnatiuc, L, et al.
Published: (2014)

Call for Special Issue Papers: Neurotrauma Reports Null Hypothesis
by: Dr. Andreas Jeromin, et al.
Published: (2020-12-01)

Remembering the null hypothesis when searching for brain sex differences
by: Lise Eliot
Published: (2024-02-01)

Sexual reproduction is the null hypothesis for life cycles of rust fungi.
by: Alistair R McTaggart, et al.
Published: (2022-05-01)

Understanding the null hypothesis (H0) in non-inferiority trials
by: Jihad Mallat
Published: (2017-05-01)

First report of expansion of CD4+/CD28 null T-helper lymphocytes in adult patients with idiopathic autoimmune hemolytic anemia
by: Soha R. Youssef, et al.
Published: (2021-10-01)

Quorum sensing in CD4+ T cell homeostasis: a hypothesis and a model.
by: Afonso R.M. Almeida, et al.
Published: (2012-05-01)

Acquisition of New Migratory Properties by Highly Differentiated CD4+CD28<sup>null</sup> T Lymphocytes in Rheumatoid Arthritis Disease
by: Beatriz Rioseras, et al.
Published: (2021-06-01)

CD28 null pro-atherogenic CD4 T-cells explain the link between CMV infection and an increased risk of cardiovascular death
by: Pera, Alejandra, et al.
Published: (2018)

Philosophical Preconditions Guide Null Hypothesis Significance Testing in Empirical Psychology
by: Fredrik Dreyer Moe
Published: (2024-03-01)

Moving beyond traditional null hypothesis testing: Evaluating expectations directly
by: Rens eVan De Schoot, et al.
Published: (2011-02-01)

Setting an optimal α that minimizes errors in null hypothesis significance tests.
by: Joseph F Mudge, et al.
Published: (2012-01-01)

Response to: Understanding the null hypothesis (H0) in non-inferiority trials
by: Xiang Zhou, et al.
Published: (2017-08-01)

Steroid-mediated liver steatosis is CD1d-dependent, while steroid-induced liver necrosis, inflammation, and metabolic changes are CD1d-independent
by: Tomer Adar, et al.
Published: (2022-04-01)

Organotypic sinonasal airway culture systems are predictive of the mucociliary phenotype produced by bronchial airway epithelial cells
by: Juliette Delhove, et al.
Published: (2022-11-01)

Dysregulation of the CD163-Haptoglobin Axis in the Airways of COPD Patients
by: Andrew Higham, et al.
Published: (2021-12-01)

The <i>CD177</i> c.1291A Allele Leads to a Loss of Membrane Expression and Mimics a CD177-Null Phenotype
by: Annalena Traum, et al.
Published: (2024-03-01)

Daidzein prevents the increase in CD4+CD28null T cells and B lymphopoesis in ovariectomized mice: a key mechanism for anti-osteoclastogenic effect.
by: Abdul Malik Tyagi, et al.
Published: (2011-01-01)