Relationship Between Venetoclax Exposure and Undetectable Minimal Residual Disease Rates in Relapsed/Refractory Patients With Chronic Lymphocytic Leukemia: A Pooled Analysis of Six Clinical Studies

Bibliographic Details
Main Authors: Sathej Gopalakrishnan, Rajeev Menon, Ahmed A. Suleiman, Arnon P. Kater, Stephan Stilgenbauer, John F. Seymour, Brenda Chyla, Tong Lu, Su Young Kim, Andrew W. Roberts, Jennifer A. Woyach, Sven Mensing, Ahmed Hamed Salem
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:HemaSphere
Online Access:http://journals.lww.com/10.1097/HS9.0000000000000983
_version_ 1797281207189241856
author Sathej Gopalakrishnan
Rajeev Menon
Ahmed A. Suleiman
Arnon P. Kater
Stephan Stilgenbauer
John F. Seymour
Brenda Chyla
Tong Lu
Su Young Kim
Andrew W. Roberts
Jennifer A. Woyach
Sven Mensing
Ahmed Hamed Salem
author_facet Sathej Gopalakrishnan
Rajeev Menon
Ahmed A. Suleiman
Arnon P. Kater
Stephan Stilgenbauer
John F. Seymour
Brenda Chyla
Tong Lu
Su Young Kim
Andrew W. Roberts
Jennifer A. Woyach
Sven Mensing
Ahmed Hamed Salem
author_sort Sathej Gopalakrishnan
collection DOAJ
first_indexed 2024-03-07T16:53:15Z
format Article
id doaj.art-a2f017128b0e46e6a3b38e44b5b505e7
institution Directory Open Access Journal
issn 2572-9241
language English
last_indexed 2024-03-07T16:53:15Z
publishDate 2023-12-01
publisher Wiley
record_format Article
series HemaSphere
spelling doaj.art-a2f017128b0e46e6a3b38e44b5b505e72024-03-03T04:31:45ZengWileyHemaSphere2572-92412023-12-01712e98310.1097/HS9.0000000000000983202312000-00003Relationship Between Venetoclax Exposure and Undetectable Minimal Residual Disease Rates in Relapsed/Refractory Patients With Chronic Lymphocytic Leukemia: A Pooled Analysis of Six Clinical StudiesSathej Gopalakrishnan0Rajeev Menon1Ahmed A. Suleiman2Arnon P. Kater3Stephan Stilgenbauer4John F. Seymour5Brenda Chyla6Tong Lu7Su Young Kim8Andrew W. Roberts9Jennifer A. Woyach10Sven Mensing11Ahmed Hamed Salem121 Clinical Pharmacology, AbbVie, Ludwigshafen, Germany2 Clinical Pharmacology, AbbVie, North Chicago, IL, USA1 Clinical Pharmacology, AbbVie, Ludwigshafen, Germany3 Department of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Center, on behalf of HOVON CLL WG, Amsterdam, The Netherlands4 Division of CLL, Department III of Internal Medicine, Ulm University, Ulm, Germany5 Department of Hematology, The Royal Melbourne Hospital and Peter MacCallum Cancer Centre, University of Melbourne, Parkville, VIC, Australia6 Precision Medicine Oncology, AbbVie, North Chicago, IL, USA7 Genentech Inc, South San Francisco, CA, USA8 Oncology Development, AbbVie, North Chicago, IL, USA5 Department of Hematology, The Royal Melbourne Hospital and Peter MacCallum Cancer Centre, University of Melbourne, Parkville, VIC, Australia9 Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA1 Clinical Pharmacology, AbbVie, Ludwigshafen, Germany2 Clinical Pharmacology, AbbVie, North Chicago, IL, USAhttp://journals.lww.com/10.1097/HS9.0000000000000983
spellingShingle Sathej Gopalakrishnan
Rajeev Menon
Ahmed A. Suleiman
Arnon P. Kater
Stephan Stilgenbauer
John F. Seymour
Brenda Chyla
Tong Lu
Su Young Kim
Andrew W. Roberts
Jennifer A. Woyach
Sven Mensing
Ahmed Hamed Salem
Relationship Between Venetoclax Exposure and Undetectable Minimal Residual Disease Rates in Relapsed/Refractory Patients With Chronic Lymphocytic Leukemia: A Pooled Analysis of Six Clinical Studies
HemaSphere
title Relationship Between Venetoclax Exposure and Undetectable Minimal Residual Disease Rates in Relapsed/Refractory Patients With Chronic Lymphocytic Leukemia: A Pooled Analysis of Six Clinical Studies
title_full Relationship Between Venetoclax Exposure and Undetectable Minimal Residual Disease Rates in Relapsed/Refractory Patients With Chronic Lymphocytic Leukemia: A Pooled Analysis of Six Clinical Studies
title_fullStr Relationship Between Venetoclax Exposure and Undetectable Minimal Residual Disease Rates in Relapsed/Refractory Patients With Chronic Lymphocytic Leukemia: A Pooled Analysis of Six Clinical Studies
title_full_unstemmed Relationship Between Venetoclax Exposure and Undetectable Minimal Residual Disease Rates in Relapsed/Refractory Patients With Chronic Lymphocytic Leukemia: A Pooled Analysis of Six Clinical Studies
title_short Relationship Between Venetoclax Exposure and Undetectable Minimal Residual Disease Rates in Relapsed/Refractory Patients With Chronic Lymphocytic Leukemia: A Pooled Analysis of Six Clinical Studies
title_sort relationship between venetoclax exposure and undetectable minimal residual disease rates in relapsed refractory patients with chronic lymphocytic leukemia a pooled analysis of six clinical studies
url http://journals.lww.com/10.1097/HS9.0000000000000983
work_keys_str_mv AT sathejgopalakrishnan relationshipbetweenvenetoclaxexposureandundetectableminimalresidualdiseaseratesinrelapsedrefractorypatientswithchroniclymphocyticleukemiaapooledanalysisofsixclinicalstudies
AT rajeevmenon relationshipbetweenvenetoclaxexposureandundetectableminimalresidualdiseaseratesinrelapsedrefractorypatientswithchroniclymphocyticleukemiaapooledanalysisofsixclinicalstudies
AT ahmedasuleiman relationshipbetweenvenetoclaxexposureandundetectableminimalresidualdiseaseratesinrelapsedrefractorypatientswithchroniclymphocyticleukemiaapooledanalysisofsixclinicalstudies
AT arnonpkater relationshipbetweenvenetoclaxexposureandundetectableminimalresidualdiseaseratesinrelapsedrefractorypatientswithchroniclymphocyticleukemiaapooledanalysisofsixclinicalstudies
AT stephanstilgenbauer relationshipbetweenvenetoclaxexposureandundetectableminimalresidualdiseaseratesinrelapsedrefractorypatientswithchroniclymphocyticleukemiaapooledanalysisofsixclinicalstudies
AT johnfseymour relationshipbetweenvenetoclaxexposureandundetectableminimalresidualdiseaseratesinrelapsedrefractorypatientswithchroniclymphocyticleukemiaapooledanalysisofsixclinicalstudies
AT brendachyla relationshipbetweenvenetoclaxexposureandundetectableminimalresidualdiseaseratesinrelapsedrefractorypatientswithchroniclymphocyticleukemiaapooledanalysisofsixclinicalstudies
AT tonglu relationshipbetweenvenetoclaxexposureandundetectableminimalresidualdiseaseratesinrelapsedrefractorypatientswithchroniclymphocyticleukemiaapooledanalysisofsixclinicalstudies
AT suyoungkim relationshipbetweenvenetoclaxexposureandundetectableminimalresidualdiseaseratesinrelapsedrefractorypatientswithchroniclymphocyticleukemiaapooledanalysisofsixclinicalstudies
AT andrewwroberts relationshipbetweenvenetoclaxexposureandundetectableminimalresidualdiseaseratesinrelapsedrefractorypatientswithchroniclymphocyticleukemiaapooledanalysisofsixclinicalstudies
AT jenniferawoyach relationshipbetweenvenetoclaxexposureandundetectableminimalresidualdiseaseratesinrelapsedrefractorypatientswithchroniclymphocyticleukemiaapooledanalysisofsixclinicalstudies
AT svenmensing relationshipbetweenvenetoclaxexposureandundetectableminimalresidualdiseaseratesinrelapsedrefractorypatientswithchroniclymphocyticleukemiaapooledanalysisofsixclinicalstudies
AT ahmedhamedsalem relationshipbetweenvenetoclaxexposureandundetectableminimalresidualdiseaseratesinrelapsedrefractorypatientswithchroniclymphocyticleukemiaapooledanalysisofsixclinicalstudies