Studies on Modulation of Gut Microbiota by Wine Polyphenols: From Isolated Cultures to Omic Approaches
Moderate consumption of wine seems to produce positive health effects derived from the occurrence of bioactive polyphenols. The gut microbiota is involved in the metabolism of phenolic compounds, and these compounds and/or their metabolites may modulate gut microbiota through the stimulation of the...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2015-01-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2076-3921/4/1/1 |
| _version_ | 1797714440543535104 |
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| author | Montserrat Dueñas Carolina Cueva Irene Muñoz-González Ana Jiménez-Girón Fernando Sánchez-Patán Celestino Santos-Buelga M. Victoria Moreno-Arribas Begoña Bartolomé |
| author_facet | Montserrat Dueñas Carolina Cueva Irene Muñoz-González Ana Jiménez-Girón Fernando Sánchez-Patán Celestino Santos-Buelga M. Victoria Moreno-Arribas Begoña Bartolomé |
| author_sort | Montserrat Dueñas |
| collection | DOAJ |
| description | Moderate consumption of wine seems to produce positive health effects derived from the occurrence of bioactive polyphenols. The gut microbiota is involved in the metabolism of phenolic compounds, and these compounds and/or their metabolites may modulate gut microbiota through the stimulation of the growth of beneficial bacteria and the inhibition of pathogenic bacteria. The characterization of bacterial metabolites derived from polyphenols is essential in order to understand their effects, including microbial modulation, and therefore to associate dietary intake with particular health effects. This review aims to summarize the current information about the two-way “wine polyphenols–gut microbiota” interaction, from a perspective based on the experimental and analytical designs used. The availability of advanced methods for monitoring bacterial communities, along with the combination of in vitro and in vivo models, could help to assess the metabolism of polyphenols in the human body and to monitor total bacterial communities, and, therefore, to elucidate the implications of diet on the modulation of microbiota for delivering health benefits. |
| first_indexed | 2024-03-12T07:52:00Z |
| format | Article |
| id | doaj.art-a2f0b881baf043b88865331aef24ac80 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T07:52:00Z |
| publishDate | 2015-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-a2f0b881baf043b88865331aef24ac802023-09-02T20:33:43ZengMDPI AGAntioxidants2076-39212015-01-014112110.3390/antiox4010001antiox4010001Studies on Modulation of Gut Microbiota by Wine Polyphenols: From Isolated Cultures to Omic ApproachesMontserrat Dueñas0Carolina Cueva1Irene Muñoz-González2Ana Jiménez-Girón3Fernando Sánchez-Patán4Celestino Santos-Buelga5M. Victoria Moreno-Arribas6Begoña Bartolomé7Grupo de Investigación en Polifenoles, Unidad de Nutrición y Bromatología, Facultad de Farmacia, Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca 37007, SpainGrupo de Biotecnología Enológica Aplicada, Instituto de Investigación en Ciencias de la Alimentación (CIAL), CSIC-UAM, C/Nicolás Cabrera 9, Campus de Cantoblanco, Madrid 28049, SpainGrupo de Biotecnología Enológica Aplicada, Instituto de Investigación en Ciencias de la Alimentación (CIAL), CSIC-UAM, C/Nicolás Cabrera 9, Campus de Cantoblanco, Madrid 28049, SpainGrupo de Biotecnología Enológica Aplicada, Instituto de Investigación en Ciencias de la Alimentación (CIAL), CSIC-UAM, C/Nicolás Cabrera 9, Campus de Cantoblanco, Madrid 28049, SpainGrupo de Biotecnología Enológica Aplicada, Instituto de Investigación en Ciencias de la Alimentación (CIAL), CSIC-UAM, C/Nicolás Cabrera 9, Campus de Cantoblanco, Madrid 28049, SpainGrupo de Investigación en Polifenoles, Unidad de Nutrición y Bromatología, Facultad de Farmacia, Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca 37007, SpainGrupo de Biotecnología Enológica Aplicada, Instituto de Investigación en Ciencias de la Alimentación (CIAL), CSIC-UAM, C/Nicolás Cabrera 9, Campus de Cantoblanco, Madrid 28049, SpainGrupo de Biotecnología Enológica Aplicada, Instituto de Investigación en Ciencias de la Alimentación (CIAL), CSIC-UAM, C/Nicolás Cabrera 9, Campus de Cantoblanco, Madrid 28049, SpainModerate consumption of wine seems to produce positive health effects derived from the occurrence of bioactive polyphenols. The gut microbiota is involved in the metabolism of phenolic compounds, and these compounds and/or their metabolites may modulate gut microbiota through the stimulation of the growth of beneficial bacteria and the inhibition of pathogenic bacteria. The characterization of bacterial metabolites derived from polyphenols is essential in order to understand their effects, including microbial modulation, and therefore to associate dietary intake with particular health effects. This review aims to summarize the current information about the two-way “wine polyphenols–gut microbiota” interaction, from a perspective based on the experimental and analytical designs used. The availability of advanced methods for monitoring bacterial communities, along with the combination of in vitro and in vivo models, could help to assess the metabolism of polyphenols in the human body and to monitor total bacterial communities, and, therefore, to elucidate the implications of diet on the modulation of microbiota for delivering health benefits.http://www.mdpi.com/2076-3921/4/1/1winepolyphenolsgut microbiotaprobioticsmodulationbatch culture fermentationgastrointestinal simulatorsanimal modelshuman studies |
| spellingShingle | Montserrat Dueñas Carolina Cueva Irene Muñoz-González Ana Jiménez-Girón Fernando Sánchez-Patán Celestino Santos-Buelga M. Victoria Moreno-Arribas Begoña Bartolomé Studies on Modulation of Gut Microbiota by Wine Polyphenols: From Isolated Cultures to Omic Approaches Antioxidants wine polyphenols gut microbiota probiotics modulation batch culture fermentation gastrointestinal simulators animal models human studies |
| title | Studies on Modulation of Gut Microbiota by Wine Polyphenols: From Isolated Cultures to Omic Approaches |
| title_full | Studies on Modulation of Gut Microbiota by Wine Polyphenols: From Isolated Cultures to Omic Approaches |
| title_fullStr | Studies on Modulation of Gut Microbiota by Wine Polyphenols: From Isolated Cultures to Omic Approaches |
| title_full_unstemmed | Studies on Modulation of Gut Microbiota by Wine Polyphenols: From Isolated Cultures to Omic Approaches |
| title_short | Studies on Modulation of Gut Microbiota by Wine Polyphenols: From Isolated Cultures to Omic Approaches |
| title_sort | studies on modulation of gut microbiota by wine polyphenols from isolated cultures to omic approaches |
| topic | wine polyphenols gut microbiota probiotics modulation batch culture fermentation gastrointestinal simulators animal models human studies |
| url | http://www.mdpi.com/2076-3921/4/1/1 |
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