High glucose induces Nox4 expression and podocyte apoptosis through the Smad3/ezrin/PKA pathway

High glucose induces Nox4 expression and podocyte apoptosis through the Smad3/ezrin/PKA pathway

Podocytes are the major target in proteinuric kidney diseases such as diabetic nephropathy. The underlying molecular mechanisms by which high glucose (HG) results in podocyte damage remain unclear. This study investigated the regulatory role of Smad3, ezrin, and protein kinase A (PKA) in NADPH oxida...

Bibliografske podrobnosti
Main Authors:	Wanxu Guo, Hang Gao, Wei Pan, Panapn Yu, Guanghua Che
Format:	Article
Jezik:	English
Izdano:	The Company of Biologists 2021-05-01
Serija:	Biology Open
Teme:	podocyte apoptosis high glucose nox4 ezrin pka smad3
Online dostop:	http://bio.biologists.org/content/10/5/bio055012

Podobne knjige/članki

The spatiotemporal matching pattern of Ezrin/Periaxin involved in myoblast differentiation and fusion and Charcot-Marie-Tooth disease-associated muscle atrophy
od: Ruo-nan Zhang, et al.
Izdano: (2023-03-01)

Prognostic Significance of SATB1, SMAD3, Ezrin and β-Catenin in Patients with Pancreatic Adenocarcinoma
od: Justyna Durślewicz, et al.
Izdano: (2021-12-01)

Puromycin aminonucleoside‐induced podocyte injury is ameliorated by the Smad3 inhibitor SIS3
od: Lina Jiang, et al.
Izdano: (2020-08-01)

Morroniside Inhibits H2O2-Induced Podocyte Apoptosis by Down-Regulating NOX4 Expression Controlled by Autophagy In Vitro
od: Xue Gao, et al.
Izdano: (2020-09-01)

Huidouba Improved Podocyte Injury by Down-Regulating Nox4 Expression in Rats With Diabetic Nephropathy
od: KunBao Yang, et al.
Izdano: (2020-11-01)

Myostatin silencing inhibits podocyte apoptosis in membranous nephropathy through Smad3/PKA/NOX4 signaling pathway
od: Wang Juan, et al.
Izdano: (2023-03-01)

Perspectives for Targeting Ezrin in Cancer Development and Progression
od: Jean Carlos Lipreri da Silva, et al.
Izdano: (2023-01-01)

Ezrin Mediates Invasion and Metastasis in Tumorigenesis: A Review
od: Yanan Song, et al.
Izdano: (2020-11-01)

Ezrin overexpression predicts the poor prognosis of gastric adenocarcinoma
od: Jin Jingchun, et al.
Izdano: (2012-10-01)

Angiotensin II Modulates Podocyte Glucose Transport
od: Barbara Lewko, et al.
Izdano: (2018-07-01)

Urolithins Modulate the Viability, Autophagy, Apoptosis, and Nephrin Turnover in Podocytes Exposed to High Glucose
od: Milena Kotewicz, et al.
Izdano: (2022-08-01)

Up Regulation of Ezrin and Radixin with respect to Grade of Tumors in Breast Cancer Patients
od: Hadiseh Mohammadpour, et al.
Izdano: (2023-10-01)

Are podoplanin and ezrin involved in the invasion process of the ameloblastomas?
od: Y.F. Costa, et al.
Izdano: (2015-02-01)

Downregulation of Ezrin Suppresses Migration Potential in Cervical Cancer Cells
od: Marta Hałas-Wiśniewska, et al.
Izdano: (2024-12-01)

A retrospective analysis of ezrin protein and mRNA expression in breast cancer: Ezrin expression is associated with patient survival and survival of patients with receptor‐positive disease
od: Sarah J. Storr, et al.
Izdano: (2023-05-01)

Btg2 Promotes Focal Segmental Glomerulosclerosis via Smad3‐Dependent Podocyte‐Mesenchymal Transition
od: Qiong‐ Dan Hu, et al.
Izdano: (2023-11-01)

Polydatin Ameliorates High Fructose-Induced Podocyte Oxidative Stress via Suppressing HIF-1α/NOX4 Pathway
od: Hong Ding, et al.
Izdano: (2022-10-01)

Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner
od: Feng-Ching Tsai, et al.
Izdano: (2018-09-01)

Ezrin expression in female reproductive tissues: A review of regulation and pathophysiological implications
od: Wen-Ting Xu, et al.
Izdano: (2023-03-01)

A Potential Invasion-Promoting Role for Ezrin in Endometrial Carcinoma
od: Ahmed R. H. Ahmed, et al.
Izdano: (2020-12-01)

Doxycycline inhibits the progression of metastases in early-stage osteosarcoma by downregulating the expression of MMPs, VEGF and ezrin at primary sites
od: Argyris C. Hadjimichael, et al.
Izdano: (2022-01-01)

Tanshinone ⅡA attenuates high glucose-induced apoptosis and oxidative stress in mouse podocyte line PMC-5
od: ZHANG Mengyao, NIU Shu, CAI Jing, ZHANG Lixiang, ZHAO Zhigang
Izdano: (2023-02-01)

Ezrin activation by LOK phosphorylation involves a PIP2-dependent wedge mechanism
od: Thaher Pelaseyed, et al.
Izdano: (2017-04-01)

Effect of Sirt1 on high glucose-induced exosome release from podocytes
od: DING Lin, ZHOU Yan, LIU Shanshan, LIU Nanchi, MA Ruixia
Izdano: (2024-02-01)

Ez-Metastasizing: The Crucial Roles of Ezrin in Metastasis
od: Rand Gabriel M. Buenaventura, et al.
Izdano: (2023-06-01)

Role of Ezrin Phosphorylation in HIV-1 Replication
od: Haruka Kamiyama, et al.
Izdano: (2018-08-01)

microRNA-211 regulates cell proliferation, apoptosis and migration/invasion in human osteosarcoma via targeting EZRIN
od: Yihua Pei, et al.
Izdano: (2019-07-01)

Smad3-Targeted Therapy Protects against Cisplatin-Induced AKI by Attenuating Programmed Cell Death and Inflammation via a NOX4-Dependent Mechanism
od: Qin Yang, et al.
Izdano: (2021-02-01)

ARHGAP18-ezrin functions as an autoregulatory module for RhoA in the assembly of distinct actin-based structures
od: Andrew T Lombardo, et al.
Izdano: (2024-01-01)

Ezrin and Its Phosphorylated Thr567 Form Are Key Regulators of Human Extravillous Trophoblast Motility and Invasion
od: Maral E. A. Tabrizi, et al.
Izdano: (2023-02-01)

The ROCK-ezrin signaling pathway mediates LPS-induced cytokine production in pulmonary alveolar epithelial cells
od: Ning Ding, et al.
Izdano: (2022-05-01)

The Protective Role of Tanshinone IIA in Silicosis Rat Model via TGF-β1/Smad Signaling Suppression, NOX4 Inhibition and Nrf2/ARE Signaling Activation
od: Feng F, et al.
Izdano: (2019-12-01)

Podoplanin promotes the carcinogenicity of gastric cancer by activating ezrin and mediating the crosstalk between tumour cells and cancer‐associated fibroblasts
od: Yueli Tian, et al.
Izdano: (2023-05-01)

The clinical prognostic significance of ezrin in patients with bone and soft tissue sarcomas: a meta‐analysis
od: Feng Wang, et al.
Izdano: (2019-10-01)

The effect of Terebinth oil on Ezrin and Moesin expression levels in rats with ovarian ischemia-reperfusion Injury
od: Gülsüm Pektanç Şengül, et al.
Izdano: (2025-02-01)

Baicalein Inhibits Proliferation Activity of Human Colorectal Cancer Cells HCT116 Through Downregulation of Ezrin
od: Zhi Chen, et al.
Izdano: (2018-09-01)

Production of Vesicular Stomatitis Virus Glycoprotein-Pseudotyped Lentiviral Vector Is Enhanced by Ezrin Silencing
od: Mai Izumida, et al.
Izdano: (2020-04-01)

Prognostic role of GPER/Ezrin in triple-negative breast cancer is associated with menopausal status
od: Shuang Ye, et al.
Izdano: (2019-05-01)

mRNA expression of ezrin in gingival crevicular fluid and whole blood of gingivitis and chronic periodontitis patients – A polymerase chain reaction study
od: Anju Cecil, et al.
Izdano: (2022-01-01)

pKalculator: A pKa predictor for C–H bonds
od: Rasmus M. Borup, et al.
Izdano: (2024-07-01)