Prevalence and clinical-pathological features of nevus-associated versus de novo melanoma: a retrospective cross-sectional study of 2806 cases
Introduction: Nevus-associated melanoma (NAM) accounts for almost one third of all cutaneous melanomas; it is often associated with younger age, trunk location and lower Breslow’s thickness compared to de novo melanoma (DNM). Objectives: To define the prevalence of NAM in a tertiary referral Cent...
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| Format: | Article |
| Language: | English |
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Mattioli1885
2022-05-01
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| Series: | Dermatology Practical & Conceptual |
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| Online Access: | https://dpcj.org/index.php/dpc/article/view/2084 |
| _version_ | 1828843440953098240 |
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| author | Caterina Longo Michela Lai Simonetta Piana Giovanni Pellacani Riccardo Pampena |
| author_facet | Caterina Longo Michela Lai Simonetta Piana Giovanni Pellacani Riccardo Pampena |
| author_sort | Caterina Longo |
| collection | DOAJ |
| description |
Introduction: Nevus-associated melanoma (NAM) accounts for almost one third of all cutaneous melanomas; it is often associated with younger age, trunk location and lower Breslow’s thickness compared to de novo melanoma (DNM).
Objectives: To define the prevalence of NAM in a tertiary referral Center in Italy and to analyze its distribution according to demographics, clinical and histopathological variables
Methods: Data were retrospectively retrieved from the archive of the Pathology Unit from June 2011 to August 2020. NAMs were compared with DNMs according to demographic, clinical and histopathological variables.
Results: A total of 2806 consecutive cases of melanoma were excised in 2537 patients. Of these, 431 (15.4%) were NAM. NAM patients were significantly younger than DNM patients (55.1±14.1 vs. 62.0±15.0 years, p<0.001); they were predominantly located on the trunk (64.0% vs. 47.9% of DNMs). Melanoma located on the head and neck, trunk and upper limbs respectively had 2.3 (95%CI:1.2-4.5, p:0.014), 3.2 (95%CI:2.1-5.1, p<0.001) and 3.5 (95%CI:2.0-6.1, p<0.001) more odds to be NAM than those on the lower limbs.
Conclusions: Our results confirm the association of NAM with younger age and trunk location. We also demonstrated that body site differences of NAM distribution are enhanced before the sixth decade of life.
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| first_indexed | 2024-12-12T20:46:14Z |
| format | Article |
| id | doaj.art-a2f109a1d0a04539a453dfaca89aedf7 |
| institution | Directory Open Access Journal |
| issn | 2160-9381 |
| language | English |
| last_indexed | 2024-12-12T20:46:14Z |
| publishDate | 2022-05-01 |
| publisher | Mattioli1885 |
| record_format | Article |
| series | Dermatology Practical & Conceptual |
| spelling | doaj.art-a2f109a1d0a04539a453dfaca89aedf72022-12-22T00:12:35ZengMattioli1885Dermatology Practical & Conceptual2160-93812022-05-0112210.5826/dpc.1202a94Prevalence and clinical-pathological features of nevus-associated versus de novo melanoma: a retrospective cross-sectional study of 2806 casesCaterina Longo0Michela Lai1Simonetta Piana2Giovanni Pellacani3Riccardo Pampena4Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy; Department of Dermatology, University of Modena and Reggio Emilia, Modena, ItalyCentro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Italy . Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy Pathology Unit, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, ItalyDermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, La Sapienza University of Rome, ItalyCentro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy; Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy Introduction: Nevus-associated melanoma (NAM) accounts for almost one third of all cutaneous melanomas; it is often associated with younger age, trunk location and lower Breslow’s thickness compared to de novo melanoma (DNM). Objectives: To define the prevalence of NAM in a tertiary referral Center in Italy and to analyze its distribution according to demographics, clinical and histopathological variables Methods: Data were retrospectively retrieved from the archive of the Pathology Unit from June 2011 to August 2020. NAMs were compared with DNMs according to demographic, clinical and histopathological variables. Results: A total of 2806 consecutive cases of melanoma were excised in 2537 patients. Of these, 431 (15.4%) were NAM. NAM patients were significantly younger than DNM patients (55.1±14.1 vs. 62.0±15.0 years, p<0.001); they were predominantly located on the trunk (64.0% vs. 47.9% of DNMs). Melanoma located on the head and neck, trunk and upper limbs respectively had 2.3 (95%CI:1.2-4.5, p:0.014), 3.2 (95%CI:2.1-5.1, p<0.001) and 3.5 (95%CI:2.0-6.1, p<0.001) more odds to be NAM than those on the lower limbs. Conclusions: Our results confirm the association of NAM with younger age and trunk location. We also demonstrated that body site differences of NAM distribution are enhanced before the sixth decade of life. https://dpcj.org/index.php/dpc/article/view/2084melanomanevus-associated melanomade novo melanoma |
| spellingShingle | Caterina Longo Michela Lai Simonetta Piana Giovanni Pellacani Riccardo Pampena Prevalence and clinical-pathological features of nevus-associated versus de novo melanoma: a retrospective cross-sectional study of 2806 cases Dermatology Practical & Conceptual melanoma nevus-associated melanoma de novo melanoma |
| title | Prevalence and clinical-pathological features of nevus-associated versus de novo melanoma: a retrospective cross-sectional study of 2806 cases |
| title_full | Prevalence and clinical-pathological features of nevus-associated versus de novo melanoma: a retrospective cross-sectional study of 2806 cases |
| title_fullStr | Prevalence and clinical-pathological features of nevus-associated versus de novo melanoma: a retrospective cross-sectional study of 2806 cases |
| title_full_unstemmed | Prevalence and clinical-pathological features of nevus-associated versus de novo melanoma: a retrospective cross-sectional study of 2806 cases |
| title_short | Prevalence and clinical-pathological features of nevus-associated versus de novo melanoma: a retrospective cross-sectional study of 2806 cases |
| title_sort | prevalence and clinical pathological features of nevus associated versus de novo melanoma a retrospective cross sectional study of 2806 cases |
| topic | melanoma nevus-associated melanoma de novo melanoma |
| url | https://dpcj.org/index.php/dpc/article/view/2084 |
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