Systematic review and subgroup analysis of the incidence of acute kidney injury (AKI) in patients with COVID-19
Abstract Background Acute kidney injury (AKI) occurs among patients with coronavirus disease-19 (COVID-19) and has also been indicated to be associated with in-hospital mortality. Remdesivir has been authorized for the treatment of COVID-19. We conducted a systematic review to evaluate the incidence...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-02-01
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| Series: | BMC Nephrology |
| Online Access: | https://doi.org/10.1186/s12882-021-02244-x |
| _version_ | 1818610023561953280 |
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| author | Zhenjian Xu Ying Tang Qiuyan Huang Sha Fu Xiaomei Li Baojuan Lin Anping Xu Junzhe Chen |
| author_facet | Zhenjian Xu Ying Tang Qiuyan Huang Sha Fu Xiaomei Li Baojuan Lin Anping Xu Junzhe Chen |
| author_sort | Zhenjian Xu |
| collection | DOAJ |
| description | Abstract Background Acute kidney injury (AKI) occurs among patients with coronavirus disease-19 (COVID-19) and has also been indicated to be associated with in-hospital mortality. Remdesivir has been authorized for the treatment of COVID-19. We conducted a systematic review to evaluate the incidence of AKI in hospitalized COVID-19 patients. The incidence of AKI in different subgroups was also investigated. Methods A thorough search was performed to find relevant studies in PubMed, Web of Science, medRxiv and EMBASE from 1 Jan 2020 until 1 June 2020. The systematic review was performed using the meta package in R (4.0.1). Results A total of 16,199 COVID-19 patients were included in our systematic review. The pooled estimated incidence of AKI in all hospitalized COVID-19 patients was 10.0% (95% CI: 7.0–12.0%). The pooled estimated proportion of COVID-19 patients who needed continuous renal replacement therapy (CRRT) was 4% (95% CI: 3–6%). According to our subgroup analysis, the incidence of AKI could be associated with age, disease severity and ethnicity. The incidence of AKI in hospitalized COVID-19 patients being treated with remdesivir was 7% (95% CI: 3–13%) in a total of 5 studies. Conclusion We found that AKI was not rare in hospitalized COVID-19 patients. The incidence of AKI could be associated with age, disease severity and ethnicity. Remdesivir probably did not induce AKI in COVID-19 patients. Our systematic review provides evidence that AKI might be closely associated with SARS-CoV-2 infection, which should be investigated in future studies. |
| first_indexed | 2024-12-16T15:07:51Z |
| format | Article |
| id | doaj.art-a2f114e652f14116bba3266ed4a5920b |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-16T15:07:51Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-a2f114e652f14116bba3266ed4a5920b2022-12-21T22:27:02ZengBMCBMC Nephrology1471-23692021-02-0122111010.1186/s12882-021-02244-xSystematic review and subgroup analysis of the incidence of acute kidney injury (AKI) in patients with COVID-19Zhenjian Xu0Ying Tang1Qiuyan Huang2Sha Fu3Xiaomei Li4Baojuan Lin5Anping Xu6Junzhe Chen7Department of Nephrology, Sun Yat-sen Memorial Hospital of Sun Yat-sen UniversityDepartment of Nephrology, The Third Affiliated Hospital, Southern Medical UniversityDepartment of Nephrology, Sun Yat-sen Memorial Hospital of Sun Yat-sen UniversityDepartment of Nephrology, Sun Yat-sen Memorial Hospital of Sun Yat-sen UniversityDepartment of Nephrology, Sun Yat-sen Memorial Hospital of Sun Yat-sen UniversityDepartment of Nephrology, Sun Yat-sen Memorial Hospital of Sun Yat-sen UniversityDepartment of Nephrology, Sun Yat-sen Memorial Hospital of Sun Yat-sen UniversityDepartment of Nephrology, Sun Yat-sen Memorial Hospital of Sun Yat-sen UniversityAbstract Background Acute kidney injury (AKI) occurs among patients with coronavirus disease-19 (COVID-19) and has also been indicated to be associated with in-hospital mortality. Remdesivir has been authorized for the treatment of COVID-19. We conducted a systematic review to evaluate the incidence of AKI in hospitalized COVID-19 patients. The incidence of AKI in different subgroups was also investigated. Methods A thorough search was performed to find relevant studies in PubMed, Web of Science, medRxiv and EMBASE from 1 Jan 2020 until 1 June 2020. The systematic review was performed using the meta package in R (4.0.1). Results A total of 16,199 COVID-19 patients were included in our systematic review. The pooled estimated incidence of AKI in all hospitalized COVID-19 patients was 10.0% (95% CI: 7.0–12.0%). The pooled estimated proportion of COVID-19 patients who needed continuous renal replacement therapy (CRRT) was 4% (95% CI: 3–6%). According to our subgroup analysis, the incidence of AKI could be associated with age, disease severity and ethnicity. The incidence of AKI in hospitalized COVID-19 patients being treated with remdesivir was 7% (95% CI: 3–13%) in a total of 5 studies. Conclusion We found that AKI was not rare in hospitalized COVID-19 patients. The incidence of AKI could be associated with age, disease severity and ethnicity. Remdesivir probably did not induce AKI in COVID-19 patients. Our systematic review provides evidence that AKI might be closely associated with SARS-CoV-2 infection, which should be investigated in future studies.https://doi.org/10.1186/s12882-021-02244-x |
| spellingShingle | Zhenjian Xu Ying Tang Qiuyan Huang Sha Fu Xiaomei Li Baojuan Lin Anping Xu Junzhe Chen Systematic review and subgroup analysis of the incidence of acute kidney injury (AKI) in patients with COVID-19 BMC Nephrology |
| title | Systematic review and subgroup analysis of the incidence of acute kidney injury (AKI) in patients with COVID-19 |
| title_full | Systematic review and subgroup analysis of the incidence of acute kidney injury (AKI) in patients with COVID-19 |
| title_fullStr | Systematic review and subgroup analysis of the incidence of acute kidney injury (AKI) in patients with COVID-19 |
| title_full_unstemmed | Systematic review and subgroup analysis of the incidence of acute kidney injury (AKI) in patients with COVID-19 |
| title_short | Systematic review and subgroup analysis of the incidence of acute kidney injury (AKI) in patients with COVID-19 |
| title_sort | systematic review and subgroup analysis of the incidence of acute kidney injury aki in patients with covid 19 |
| url | https://doi.org/10.1186/s12882-021-02244-x |
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