Viability and proliferation of endothelial cells upon exposure to GaN nanoparticles
Nanotechnology is a rapidly growing and promising field of interest in medicine; however, nanoparticle–cell interactions are not yet fully understood. The goal of this work was to examine the interaction between endothelial cells and gallium nitride (GaN) semiconductor nanoparticles. Cellular viabil...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Beilstein-Institut
2016-09-01
|
| Series: | Beilstein Journal of Nanotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjnano.7.124 |
| _version_ | 1818179908202921984 |
|---|---|
| author | Tudor Braniste Ion Tiginyanu Tibor Horvath Simion Raevschi Serghei Cebotari Marco Lux Axel Haverich Andres Hilfiker |
| author_facet | Tudor Braniste Ion Tiginyanu Tibor Horvath Simion Raevschi Serghei Cebotari Marco Lux Axel Haverich Andres Hilfiker |
| author_sort | Tudor Braniste |
| collection | DOAJ |
| description | Nanotechnology is a rapidly growing and promising field of interest in medicine; however, nanoparticle–cell interactions are not yet fully understood. The goal of this work was to examine the interaction between endothelial cells and gallium nitride (GaN) semiconductor nanoparticles. Cellular viability, adhesion, proliferation, and uptake of nanoparticles by endothelial cells were investigated. The effect of free GaN nanoparticles versus the effect of growing endothelial cells on GaN functionalized surfaces was examined. To functionalize surfaces with GaN, GaN nanoparticles were synthesized on a sacrificial layer of zinc oxide (ZnO) nanoparticles using hydride vapor phase epitaxy. The uptake of GaN nanoparticles by porcine endothelial cells was strongly dependent upon whether they were fixed to the substrate surface or free floating in the medium. The endothelial cells grown on surfaces functionalized with GaN nanoparticles demonstrated excellent adhesion and proliferation, suggesting good biocompatibility of the nanostructured GaN. |
| first_indexed | 2024-12-11T21:11:21Z |
| format | Article |
| id | doaj.art-a2f2f0da9f4845e5a5c457eb91869b1d |
| institution | Directory Open Access Journal |
| issn | 2190-4286 |
| language | English |
| last_indexed | 2024-12-11T21:11:21Z |
| publishDate | 2016-09-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Nanotechnology |
| spelling | doaj.art-a2f2f0da9f4845e5a5c457eb91869b1d2022-12-22T00:50:43ZengBeilstein-InstitutBeilstein Journal of Nanotechnology2190-42862016-09-01711330133710.3762/bjnano.7.1242190-4286-7-124Viability and proliferation of endothelial cells upon exposure to GaN nanoparticlesTudor Braniste0Ion Tiginyanu1Tibor Horvath2Simion Raevschi3Serghei Cebotari4Marco Lux5Axel Haverich6Andres Hilfiker7National Center for Materials Study and Testing, Technical University of Moldova, bv. Stefan cel Mare 168, MD-2004 Chisinau, Republic of MoldovaNational Center for Materials Study and Testing, Technical University of Moldova, bv. Stefan cel Mare 168, MD-2004 Chisinau, Republic of MoldovaLeibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Carl Neuberg Str. 1, D-30625 Hannover, GermanyDepartment of Physics and Engineering, State University of Moldova, str. Alexe Mateevici 60, MD-2009 Chisinau, Republic of MoldovaLeibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Carl Neuberg Str. 1, D-30625 Hannover, GermanyLeibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Carl Neuberg Str. 1, D-30625 Hannover, GermanyLeibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Carl Neuberg Str. 1, D-30625 Hannover, GermanyLeibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Carl Neuberg Str. 1, D-30625 Hannover, GermanyNanotechnology is a rapidly growing and promising field of interest in medicine; however, nanoparticle–cell interactions are not yet fully understood. The goal of this work was to examine the interaction between endothelial cells and gallium nitride (GaN) semiconductor nanoparticles. Cellular viability, adhesion, proliferation, and uptake of nanoparticles by endothelial cells were investigated. The effect of free GaN nanoparticles versus the effect of growing endothelial cells on GaN functionalized surfaces was examined. To functionalize surfaces with GaN, GaN nanoparticles were synthesized on a sacrificial layer of zinc oxide (ZnO) nanoparticles using hydride vapor phase epitaxy. The uptake of GaN nanoparticles by porcine endothelial cells was strongly dependent upon whether they were fixed to the substrate surface or free floating in the medium. The endothelial cells grown on surfaces functionalized with GaN nanoparticles demonstrated excellent adhesion and proliferation, suggesting good biocompatibility of the nanostructured GaN.https://doi.org/10.3762/bjnano.7.124endothelial cellsGaN nanoparticlesproliferationsurface functionalization |
| spellingShingle | Tudor Braniste Ion Tiginyanu Tibor Horvath Simion Raevschi Serghei Cebotari Marco Lux Axel Haverich Andres Hilfiker Viability and proliferation of endothelial cells upon exposure to GaN nanoparticles Beilstein Journal of Nanotechnology endothelial cells GaN nanoparticles proliferation surface functionalization |
| title | Viability and proliferation of endothelial cells upon exposure to GaN nanoparticles |
| title_full | Viability and proliferation of endothelial cells upon exposure to GaN nanoparticles |
| title_fullStr | Viability and proliferation of endothelial cells upon exposure to GaN nanoparticles |
| title_full_unstemmed | Viability and proliferation of endothelial cells upon exposure to GaN nanoparticles |
| title_short | Viability and proliferation of endothelial cells upon exposure to GaN nanoparticles |
| title_sort | viability and proliferation of endothelial cells upon exposure to gan nanoparticles |
| topic | endothelial cells GaN nanoparticles proliferation surface functionalization |
| url | https://doi.org/10.3762/bjnano.7.124 |
| work_keys_str_mv | AT tudorbraniste viabilityandproliferationofendothelialcellsuponexposuretogannanoparticles AT iontiginyanu viabilityandproliferationofendothelialcellsuponexposuretogannanoparticles AT tiborhorvath viabilityandproliferationofendothelialcellsuponexposuretogannanoparticles AT simionraevschi viabilityandproliferationofendothelialcellsuponexposuretogannanoparticles AT sergheicebotari viabilityandproliferationofendothelialcellsuponexposuretogannanoparticles AT marcolux viabilityandproliferationofendothelialcellsuponexposuretogannanoparticles AT axelhaverich viabilityandproliferationofendothelialcellsuponexposuretogannanoparticles AT andreshilfiker viabilityandproliferationofendothelialcellsuponexposuretogannanoparticles |