Validation of the Simplified UVB Model to Assess the Pharmacodynamics of Analgesics in Healthy Human Volunteers
A pharmacokinetic/pharmacodynamic, randomized, crossover, placebo-controlled study was conducted in healthy human volunteers with the primary objective of exploring the existence of a positive interaction between paracetamol 1 g and ketorolac 20 mg intravenously on experimental pain models...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
2012-05-01
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| Series: | CHIMIA |
| Subjects: | |
| Online Access: | https://www.chimia.ch/chimia/article/view/5211 |
| _version_ | 1818282448093446144 |
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| author | Kuntheavy Ing Lorenzini Marie Besson Youssef Daali Denis Salomon Pierre Dayer Jules Desmeules |
| author_facet | Kuntheavy Ing Lorenzini Marie Besson Youssef Daali Denis Salomon Pierre Dayer Jules Desmeules |
| author_sort | Kuntheavy Ing Lorenzini |
| collection | DOAJ |
| description |
A pharmacokinetic/pharmacodynamic, randomized, crossover, placebo-controlled study was conducted in healthy human volunteers with the primary objective of exploring the existence of a positive interaction between paracetamol 1 g and ketorolac 20 mg intravenously on experimental pain
models. Further, the simplified UVB model was validated as a screening tool for analgesics or a combination of analgesics in clinical drug development. It was observed that the UVB irradiation induced primary hyperalgesia, evidenced by significant decreases of the heat pain threshold from
(mean ± SD) 46.9 ± 1.1 °C to 40.1 ± 1.7 °C (p |
| first_indexed | 2024-12-13T00:21:10Z |
| format | Article |
| id | doaj.art-a2f5099c5aca4b59a098ba7aa4eb147f |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-12-13T00:21:10Z |
| publishDate | 2012-05-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-a2f5099c5aca4b59a098ba7aa4eb147f2022-12-22T00:05:34ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242012-05-0166510.2533/chimia.2012.296Validation of the Simplified UVB Model to Assess the Pharmacodynamics of Analgesics in Healthy Human VolunteersKuntheavy Ing Lorenzini0Marie Besson1Youssef Daali2Denis Salomon3Pierre Dayer4Jules Desmeules5Division of clinical pharmacology and toxicology University Hospitals of Geneva Rue Gabrielle-Perret-Gentil 4, CH-1211 Geneva, Switzerland; Faculty of Medicine University of Geneva 1 rue Michel-Servet, CH-1211 Geneva 4, SwitzerlandDivision of clinical pharmacology and toxicology University Hospitals of Geneva Rue Gabrielle-Perret-Gentil 4, CH-1211 Geneva, Switzerland; Faculty of Medicine University of Geneva 1 rue Michel-Servet, CH-1211 Geneva 4, SwitzerlandDivision of clinical pharmacology and toxicology University Hospitals of Geneva Rue Gabrielle-Perret-Gentil 4, CH-1211 Geneva, Switzerland; Faculty of Medicine University of Geneva 1 rue Michel-Servet, CH-1211 Geneva 4, SwitzerlandFaculty of Medicine University of Geneva 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland; Division of Dermatology and Venerology University Hospitals of Geneva Rue Gabrielle-Perret-Gentil 4, CH-1211 Geneva, SwitzerlandDivision of clinical pharmacology and toxicology University Hospitals of Geneva Rue Gabrielle-Perret-Gentil 4, CH-1211 Geneva, Switzerland; Faculty of Medicine University of Geneva 1 rue Michel-Servet, CH-1211 Geneva 4, SwitzerlandDivision of clinical pharmacology and toxicology University Hospitals of Geneva Rue Gabrielle-Perret-Gentil 4, CH-1211 Geneva, Switzerland; Faculty of Medicine University of Geneva 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland. jules.desmeules@hcuge.ch A pharmacokinetic/pharmacodynamic, randomized, crossover, placebo-controlled study was conducted in healthy human volunteers with the primary objective of exploring the existence of a positive interaction between paracetamol 1 g and ketorolac 20 mg intravenously on experimental pain models. Further, the simplified UVB model was validated as a screening tool for analgesics or a combination of analgesics in clinical drug development. It was observed that the UVB irradiation induced primary hyperalgesia, evidenced by significant decreases of the heat pain threshold from (mean ± SD) 46.9 ± 1.1 °C to 40.1 ± 1.7 °C (p https://www.chimia.ch/chimia/article/view/5211Analgesics combinationNsaidsParacetamolUvbVariability |
| spellingShingle | Kuntheavy Ing Lorenzini Marie Besson Youssef Daali Denis Salomon Pierre Dayer Jules Desmeules Validation of the Simplified UVB Model to Assess the Pharmacodynamics of Analgesics in Healthy Human Volunteers CHIMIA Analgesics combination Nsaids Paracetamol Uvb Variability |
| title | Validation of the Simplified UVB Model to Assess the Pharmacodynamics of Analgesics in Healthy Human Volunteers |
| title_full | Validation of the Simplified UVB Model to Assess the Pharmacodynamics of Analgesics in Healthy Human Volunteers |
| title_fullStr | Validation of the Simplified UVB Model to Assess the Pharmacodynamics of Analgesics in Healthy Human Volunteers |
| title_full_unstemmed | Validation of the Simplified UVB Model to Assess the Pharmacodynamics of Analgesics in Healthy Human Volunteers |
| title_short | Validation of the Simplified UVB Model to Assess the Pharmacodynamics of Analgesics in Healthy Human Volunteers |
| title_sort | validation of the simplified uvb model to assess the pharmacodynamics of analgesics in healthy human volunteers |
| topic | Analgesics combination Nsaids Paracetamol Uvb Variability |
| url | https://www.chimia.ch/chimia/article/view/5211 |
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