Intradermal acupuncture in the treatment of rheumatoid arthritis with liver and kidney deficiency syndrome – A sham-controlled, randomized, clinical trial
Background and purpose: Rheumatoid arthritis (RA) is called “immortal cancer”, and it affects the quality of life, disability rate and even the survival of patients. This study aimed to observe the clinical efficacy, and adverse reactions of intradermal acupuncture (IA) in the treatment of RA patien...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-06-01
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| Series: | Complementary Therapies in Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0965229924000256 |
| _version_ | 1797214910427430912 |
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| author | Huifang Luo Ping Du Wenyan Qin Yiyi Hu Zhen Xian Changsong Lin Peiwu Li Yang Song Xiangwei Yang |
| author_facet | Huifang Luo Ping Du Wenyan Qin Yiyi Hu Zhen Xian Changsong Lin Peiwu Li Yang Song Xiangwei Yang |
| author_sort | Huifang Luo |
| collection | DOAJ |
| description | Background and purpose: Rheumatoid arthritis (RA) is called “immortal cancer”, and it affects the quality of life, disability rate and even the survival of patients. This study aimed to observe the clinical efficacy, and adverse reactions of intradermal acupuncture (IA) in the treatment of RA patients with liver and kidney deficiency syndrome. Materials and methods: 132 RA patients were split into an IA group and a sham IA group at a 1:1 ratio. Both groups were assessed before and after the intervention with the assessments: a traditional Chinese medicine (TCM) syndrome evaluation, the Health Assessment Questionnaire (HAQ), the Disease Activity Score 28 (DAS28) and serum C-reactive protein (CRP). Results: There was a statistically significant difference in TCM syndrome evaluation, HAQ, DAS28, and CRP between both groups before and after treatment (P < 0.01). The improvement of TCM syndrome evaluation (95% CI [1.14(0.38–1.89)]; P = 0.001), HAQ (95% CI [2.00(1.00–3.00)]; P = 0.003), and DAS28 (95% CI [0.11(0.02–0.20)]; P = 0.021) in the IA group was more obvious than that in the sham IA group (P < 0.05), except for CRP (95% CI [0.50(− 2.09 to 7.08)], P = 0.786). The difference in CRP outcome changes between the two groups was not statistically significant (P > 0.05). Both groups had comparable results in the implementation of RA in the upper and lower extremity acupoints and did not differ due to different sites (IA group: P = 0.852; sham IA group: P = 0.861). The comparison of effective rate of the upper limb as well as that of the lower limb was statistically significant (P = 0.001). Besides, patients reported no adverse effects. Conclusion: The IA intervention was associated with a promising effect on the decrease in RA disease activity and delayed overall disease progression. |
| first_indexed | 2024-04-24T11:21:41Z |
| format | Article |
| id | doaj.art-a2f611978f004c77a8dded77154975c9 |
| institution | Directory Open Access Journal |
| issn | 0965-2299 |
| language | English |
| last_indexed | 2024-04-24T11:21:41Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Complementary Therapies in Medicine |
| spelling | doaj.art-a2f611978f004c77a8dded77154975c92024-04-11T04:40:51ZengElsevierComplementary Therapies in Medicine0965-22992024-06-0182103037Intradermal acupuncture in the treatment of rheumatoid arthritis with liver and kidney deficiency syndrome – A sham-controlled, randomized, clinical trialHuifang Luo0Ping Du1Wenyan Qin2Yiyi Hu3Zhen Xian4Changsong Lin5Peiwu Li6Yang Song7Xiangwei Yang8School of Nursing, Shantou University Medical College, Shantou, Guangdong, ChinaSchool of Nursing, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaSchool of Nursing, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaGuangzhou University of Traditional Chinese Medicine First Affiliated Hospital, Guangzhou, Guangdong, ChinaGuangzhou University of Traditional Chinese Medicine First Affiliated Hospital, Guangzhou, Guangdong, ChinaGuangzhou University of Traditional Chinese Medicine First Affiliated Hospital, Guangzhou, Guangdong, ChinaGuangzhou University of Traditional Chinese Medicine First Affiliated Hospital, Guangzhou, Guangdong, ChinaSchool of Nursing, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; Correspondence to: School of Nursing, Guangzhou University of Chinese Medicine, Guangzhou, China.Guangzhou University of Traditional Chinese Medicine First Affiliated Hospital, Guangzhou, Guangdong, China; Correspondence to: Department of Rheumatology, Guangzhou University of Traditional Chinese Medicine First Affiliated Hospital, Guangzhou, Guangdong, China.Background and purpose: Rheumatoid arthritis (RA) is called “immortal cancer”, and it affects the quality of life, disability rate and even the survival of patients. This study aimed to observe the clinical efficacy, and adverse reactions of intradermal acupuncture (IA) in the treatment of RA patients with liver and kidney deficiency syndrome. Materials and methods: 132 RA patients were split into an IA group and a sham IA group at a 1:1 ratio. Both groups were assessed before and after the intervention with the assessments: a traditional Chinese medicine (TCM) syndrome evaluation, the Health Assessment Questionnaire (HAQ), the Disease Activity Score 28 (DAS28) and serum C-reactive protein (CRP). Results: There was a statistically significant difference in TCM syndrome evaluation, HAQ, DAS28, and CRP between both groups before and after treatment (P < 0.01). The improvement of TCM syndrome evaluation (95% CI [1.14(0.38–1.89)]; P = 0.001), HAQ (95% CI [2.00(1.00–3.00)]; P = 0.003), and DAS28 (95% CI [0.11(0.02–0.20)]; P = 0.021) in the IA group was more obvious than that in the sham IA group (P < 0.05), except for CRP (95% CI [0.50(− 2.09 to 7.08)], P = 0.786). The difference in CRP outcome changes between the two groups was not statistically significant (P > 0.05). Both groups had comparable results in the implementation of RA in the upper and lower extremity acupoints and did not differ due to different sites (IA group: P = 0.852; sham IA group: P = 0.861). The comparison of effective rate of the upper limb as well as that of the lower limb was statistically significant (P = 0.001). Besides, patients reported no adverse effects. Conclusion: The IA intervention was associated with a promising effect on the decrease in RA disease activity and delayed overall disease progression.http://www.sciencedirect.com/science/article/pii/S0965229924000256Intradermal acupunctureRheumatoid arthritisLiver and kidney deficiency syndromeClinical trial |
| spellingShingle | Huifang Luo Ping Du Wenyan Qin Yiyi Hu Zhen Xian Changsong Lin Peiwu Li Yang Song Xiangwei Yang Intradermal acupuncture in the treatment of rheumatoid arthritis with liver and kidney deficiency syndrome – A sham-controlled, randomized, clinical trial Complementary Therapies in Medicine Intradermal acupuncture Rheumatoid arthritis Liver and kidney deficiency syndrome Clinical trial |
| title | Intradermal acupuncture in the treatment of rheumatoid arthritis with liver and kidney deficiency syndrome – A sham-controlled, randomized, clinical trial |
| title_full | Intradermal acupuncture in the treatment of rheumatoid arthritis with liver and kidney deficiency syndrome – A sham-controlled, randomized, clinical trial |
| title_fullStr | Intradermal acupuncture in the treatment of rheumatoid arthritis with liver and kidney deficiency syndrome – A sham-controlled, randomized, clinical trial |
| title_full_unstemmed | Intradermal acupuncture in the treatment of rheumatoid arthritis with liver and kidney deficiency syndrome – A sham-controlled, randomized, clinical trial |
| title_short | Intradermal acupuncture in the treatment of rheumatoid arthritis with liver and kidney deficiency syndrome – A sham-controlled, randomized, clinical trial |
| title_sort | intradermal acupuncture in the treatment of rheumatoid arthritis with liver and kidney deficiency syndrome a sham controlled randomized clinical trial |
| topic | Intradermal acupuncture Rheumatoid arthritis Liver and kidney deficiency syndrome Clinical trial |
| url | http://www.sciencedirect.com/science/article/pii/S0965229924000256 |
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