Effect of cholesterol feeding and fasting on sterol synthesis in seventeen tissues of the rat
Rates of sterol synthesis were measured in 17 tissues of the rat, and the responsiveness of these rates to cholesterol feeding and to fasting was determined. The liver and gastrointestinal tract together account for 90% of synthetic activity of the whole body. After the rats had been fed cholesterol...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
1967-03-01
|
| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520389215 |
| _version_ | 1818330161742872576 |
|---|---|
| author | John M. Dietschy Marvin D. Siperstein |
| author_facet | John M. Dietschy Marvin D. Siperstein |
| author_sort | John M. Dietschy |
| collection | DOAJ |
| description | Rates of sterol synthesis were measured in 17 tissues of the rat, and the responsiveness of these rates to cholesterol feeding and to fasting was determined. The liver and gastrointestinal tract together account for 90% of synthetic activity of the whole body. After the rats had been fed cholesterol or fasted, liver synthesis was markedly decreased, whereas synthetic rates in all other organs tested were essentially unaffected (this conclusion applies to synthesis of cholesterol and of five other digitonin-precipitable tissue sterols). Consequently, the highest rate of cholesterogenesis in the cholesterolfed or fasted rat is found in the gastrointestinal tract. |
| first_indexed | 2024-12-13T12:59:33Z |
| format | Article |
| id | doaj.art-a2f71dc0025342dca03ffb0c99817c4e |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-13T12:59:33Z |
| publishDate | 1967-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-a2f71dc0025342dca03ffb0c99817c4e2022-12-21T23:45:05ZengElsevierJournal of Lipid Research0022-22751967-03-018297104Effect of cholesterol feeding and fasting on sterol synthesis in seventeen tissues of the ratJohn M. Dietschy0Marvin D. Siperstein1Department of Internal Medicine, The University of Texas Southwestern Medical School, Dallas, Texas 75235Department of Internal Medicine, The University of Texas Southwestern Medical School, Dallas, Texas 75235Rates of sterol synthesis were measured in 17 tissues of the rat, and the responsiveness of these rates to cholesterol feeding and to fasting was determined. The liver and gastrointestinal tract together account for 90% of synthetic activity of the whole body. After the rats had been fed cholesterol or fasted, liver synthesis was markedly decreased, whereas synthetic rates in all other organs tested were essentially unaffected (this conclusion applies to synthesis of cholesterol and of five other digitonin-precipitable tissue sterols). Consequently, the highest rate of cholesterogenesis in the cholesterolfed or fasted rat is found in the gastrointestinal tract.http://www.sciencedirect.com/science/article/pii/S0022227520389215ratcholesterol synthesisliverintestineextrahepatic tissuesfeedback control |
| spellingShingle | John M. Dietschy Marvin D. Siperstein Effect of cholesterol feeding and fasting on sterol synthesis in seventeen tissues of the rat Journal of Lipid Research rat cholesterol synthesis liver intestine extrahepatic tissues feedback control |
| title | Effect of cholesterol feeding and fasting on sterol synthesis in seventeen tissues of the rat |
| title_full | Effect of cholesterol feeding and fasting on sterol synthesis in seventeen tissues of the rat |
| title_fullStr | Effect of cholesterol feeding and fasting on sterol synthesis in seventeen tissues of the rat |
| title_full_unstemmed | Effect of cholesterol feeding and fasting on sterol synthesis in seventeen tissues of the rat |
| title_short | Effect of cholesterol feeding and fasting on sterol synthesis in seventeen tissues of the rat |
| title_sort | effect of cholesterol feeding and fasting on sterol synthesis in seventeen tissues of the rat |
| topic | rat cholesterol synthesis liver intestine extrahepatic tissues feedback control |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520389215 |
| work_keys_str_mv | AT johnmdietschy effectofcholesterolfeedingandfastingonsterolsynthesisinseventeentissuesoftherat AT marvindsiperstein effectofcholesterolfeedingandfastingonsterolsynthesisinseventeentissuesoftherat |