Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin
Osteocytes reside in a low oxygen environment, but it is not clear if oxygen sensing regulates their function. Here, the authors show that deletion of the oxygen sensor prolyl hydroxylase 2 in osteocytes leads to increased bone mass via regulation of sclerostin, and reduces bone loss in mouse models...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-04679-7 |