Increased urinary markers of kidney damage in the institutionalized frail elderly due to recurrent urinary tract infections
Objective: To characterize the impact on kidney injury of recurrent urinary tract infections (RUTI) in the frail elderly. Methods: Prospective observational study in 200 frail elderly subjects for 1 year. Groups: GA ( n = 100): subjects without RUTI, GB ( n = 100): subjects with RUTI. Variables: a...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2020-12-01
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| Series: | Therapeutic Advances in Urology |
| Online Access: | https://doi.org/10.1177/1756287220974133 |
| _version_ | 1818880319360598016 |
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| author | María-Fernanda Lorenzo-Gómez María-Carmen Flores-Fraile Magaly Márquez-Sánchez Javier Flores-Fraile Ignacio González-Casado Bárbara Padilla-Fernández Sebastián Valverde-Martínez Teresa Hernández Sánchez Carlos Muller-Arteaga María-Begoña García-Cenador |
| author_facet | María-Fernanda Lorenzo-Gómez María-Carmen Flores-Fraile Magaly Márquez-Sánchez Javier Flores-Fraile Ignacio González-Casado Bárbara Padilla-Fernández Sebastián Valverde-Martínez Teresa Hernández Sánchez Carlos Muller-Arteaga María-Begoña García-Cenador |
| author_sort | María-Fernanda Lorenzo-Gómez |
| collection | DOAJ |
| description | Objective: To characterize the impact on kidney injury of recurrent urinary tract infections (RUTI) in the frail elderly. Methods: Prospective observational study in 200 frail elderly subjects for 1 year. Groups: GA ( n = 100): subjects without RUTI, GB ( n = 100): subjects with RUTI. Variables: age, concomitant diseases, glomerular filtration rate (GFR), urine neutrophil gelatinase-associated lipocalin (NGAL) at the beginning (NGAL-1) and end (NGAL-2) of the study, urine N-acetyl glucosaminidase (NAG) at the beginning (NAG-1) and the end (NAG-2) of the study, urine transforming growth factor-beta 1 (TGFβ-1). Descriptive statistics, Mann–Whitney test, Chi-squared test, Fisher’s exact test, and multivariate analysis were used. Results: Mean age was 84.33 (65–99) years old, with no difference between GA and GB. Mean NGAL-1 was 1.29 ng/ml (0.04–8). There was lower in GA than in GB. Mean NGAL-2 was 1.41 ng/ml (0.02–9.22). NGAL-2 was lower in GA than in GB. Mean NAG-1 was 0.38 UU.II/ml (0.01–2.63. NAG-1 in GA was lower than in GB. Mean NAG-2 was 0.44 UU.II/ml (0–3.41). NAG-2 was lower in GA compared with GB. Mean TGFβ-1 was 23.43 pg/ml (0.02–103.76). TGFβ-1 was lower in GA than GB. There were no differences in the presence of secondary diagnoses between GA and GB. NAG-2 and NGAL-1 were the most determining factors of renal function; in GA it was NGAL-2, followed by NAG-1; in GB it was NGAL-1, followed by NAG-2. Conclusion: Frail elderly with RUTI have higher urinary levels of renal injury markers, specifically NGAL, NAG, and TGFβ-1, chronically in periods between urinary tract infection (UTI). Urinary markers of renal injury, specifically NGAL, NAG, and TGFβ-1, identify early deterioration of renal function, compared with serum creatinine, or albuminuria, in frail elderly with recurrent urinary infections. |
| first_indexed | 2024-12-19T14:44:05Z |
| format | Article |
| id | doaj.art-a2f7b0c61c344af58c65485c46d13716 |
| institution | Directory Open Access Journal |
| issn | 1756-2880 |
| language | English |
| last_indexed | 2024-12-19T14:44:05Z |
| publishDate | 2020-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Urology |
| spelling | doaj.art-a2f7b0c61c344af58c65485c46d137162022-12-21T20:17:00ZengSAGE PublishingTherapeutic Advances in Urology1756-28802020-12-011210.1177/1756287220974133Increased urinary markers of kidney damage in the institutionalized frail elderly due to recurrent urinary tract infectionsMaría-Fernanda Lorenzo-GómezMaría-Carmen Flores-FraileMagaly Márquez-SánchezJavier Flores-FraileIgnacio González-CasadoBárbara Padilla-FernándezSebastián Valverde-MartínezTeresa Hernández SánchezCarlos Muller-ArteagaMaría-Begoña García-CenadorObjective: To characterize the impact on kidney injury of recurrent urinary tract infections (RUTI) in the frail elderly. Methods: Prospective observational study in 200 frail elderly subjects for 1 year. Groups: GA ( n = 100): subjects without RUTI, GB ( n = 100): subjects with RUTI. Variables: age, concomitant diseases, glomerular filtration rate (GFR), urine neutrophil gelatinase-associated lipocalin (NGAL) at the beginning (NGAL-1) and end (NGAL-2) of the study, urine N-acetyl glucosaminidase (NAG) at the beginning (NAG-1) and the end (NAG-2) of the study, urine transforming growth factor-beta 1 (TGFβ-1). Descriptive statistics, Mann–Whitney test, Chi-squared test, Fisher’s exact test, and multivariate analysis were used. Results: Mean age was 84.33 (65–99) years old, with no difference between GA and GB. Mean NGAL-1 was 1.29 ng/ml (0.04–8). There was lower in GA than in GB. Mean NGAL-2 was 1.41 ng/ml (0.02–9.22). NGAL-2 was lower in GA than in GB. Mean NAG-1 was 0.38 UU.II/ml (0.01–2.63. NAG-1 in GA was lower than in GB. Mean NAG-2 was 0.44 UU.II/ml (0–3.41). NAG-2 was lower in GA compared with GB. Mean TGFβ-1 was 23.43 pg/ml (0.02–103.76). TGFβ-1 was lower in GA than GB. There were no differences in the presence of secondary diagnoses between GA and GB. NAG-2 and NGAL-1 were the most determining factors of renal function; in GA it was NGAL-2, followed by NAG-1; in GB it was NGAL-1, followed by NAG-2. Conclusion: Frail elderly with RUTI have higher urinary levels of renal injury markers, specifically NGAL, NAG, and TGFβ-1, chronically in periods between urinary tract infection (UTI). Urinary markers of renal injury, specifically NGAL, NAG, and TGFβ-1, identify early deterioration of renal function, compared with serum creatinine, or albuminuria, in frail elderly with recurrent urinary infections.https://doi.org/10.1177/1756287220974133 |
| spellingShingle | María-Fernanda Lorenzo-Gómez María-Carmen Flores-Fraile Magaly Márquez-Sánchez Javier Flores-Fraile Ignacio González-Casado Bárbara Padilla-Fernández Sebastián Valverde-Martínez Teresa Hernández Sánchez Carlos Muller-Arteaga María-Begoña García-Cenador Increased urinary markers of kidney damage in the institutionalized frail elderly due to recurrent urinary tract infections Therapeutic Advances in Urology |
| title | Increased urinary markers of kidney damage in the institutionalized frail elderly due to recurrent urinary tract infections |
| title_full | Increased urinary markers of kidney damage in the institutionalized frail elderly due to recurrent urinary tract infections |
| title_fullStr | Increased urinary markers of kidney damage in the institutionalized frail elderly due to recurrent urinary tract infections |
| title_full_unstemmed | Increased urinary markers of kidney damage in the institutionalized frail elderly due to recurrent urinary tract infections |
| title_short | Increased urinary markers of kidney damage in the institutionalized frail elderly due to recurrent urinary tract infections |
| title_sort | increased urinary markers of kidney damage in the institutionalized frail elderly due to recurrent urinary tract infections |
| url | https://doi.org/10.1177/1756287220974133 |
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