Dosimetric Comparing between Protons Beam and Photons Beam for Lung Cancer Radiotherapy: A Meta-analysis
Background and objective The clinical evidences are not sufficient on the proton beam therapy of lung cancer for lacking of the RCTs on the comparing the proton with the photon beam in lung cancer radiotherapy. The aim of this study is to evaluate the dosimetry superiority of the proton beam and pro...
| Main Authors: | , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2013-05-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2013.05.07 |
| _version_ | 1818177536927989760 |
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| author | Guangwei TIAN Nan LI Guang LI |
| author_facet | Guangwei TIAN Nan LI Guang LI |
| author_sort | Guangwei TIAN |
| collection | DOAJ |
| description | Background and objective The clinical evidences are not sufficient on the proton beam therapy of lung cancer for lacking of the RCTs on the comparing the proton with the photon beam in lung cancer radiotherapy. The aim of this study is to evaluate the dosimetry superiority of the proton beam and provide more valuable evidences to the clinical researches. Methods Clinical trails of dosimetric comparing between protons beam and photons beam for lung cancer radiotherapy were obtained from the Cochrane library, Pubmed, EMbase, CBM, CNKI, VIP, and Wan Fang databases. The data included in the study were evaluated and analyzed using the Cochrane Collaboration's RevMan 5.2 software. Results Six trails were included. Compared to photon therapy (three-dimensional conformal photon radiotherapy, 3D-CRT), the proton therapy had a significantly lower total lung Dmean (MD=-4.15, 95%CI: -5.56--2.74, P<0.001) and V20, V10, V5 (MD=-10.92, 95%CI: -13.23--8.62, P<0.001); The V20, V10, V5 significantly decreased in proton therapy group. Compared to photon therapy (intensity-modulated photon radiotherapy, IMRT), V20, V10, V5 were also significantly lowered in proton therapy group (MD=-3.70, 95%CI: -5.31--2.10, P<0.001; MD=-8.86, 95%CI: -10.74--6.98, P<0.001; MD=-20.13, 95%CI: -27.11--13.14, P<0.001); The esophagus Dmean was not lowered, while the heart Dmean decreased in proton therapy group. Conclusion Comparing to photon beam radiotherapy (3D-CRT and IMRT), proton beam therapy is advantageous in dosimetry of the lung cancer radiotherapy and recommended for clinical applying. |
| first_indexed | 2024-12-11T20:33:39Z |
| format | Article |
| id | doaj.art-a2f8edc8d98341d49e69ff092748b075 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-12-11T20:33:39Z |
| publishDate | 2013-05-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-a2f8edc8d98341d49e69ff092748b0752022-12-22T00:51:45ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872013-05-0116525226010.3779/j.issn.1009-3419.2013.05.07Dosimetric Comparing between Protons Beam and Photons Beam
for Lung Cancer Radiotherapy: A Meta-analysisGuangwei TIANNan LIGuang LIBackground and objective The clinical evidences are not sufficient on the proton beam therapy of lung cancer for lacking of the RCTs on the comparing the proton with the photon beam in lung cancer radiotherapy. The aim of this study is to evaluate the dosimetry superiority of the proton beam and provide more valuable evidences to the clinical researches. Methods Clinical trails of dosimetric comparing between protons beam and photons beam for lung cancer radiotherapy were obtained from the Cochrane library, Pubmed, EMbase, CBM, CNKI, VIP, and Wan Fang databases. The data included in the study were evaluated and analyzed using the Cochrane Collaboration's RevMan 5.2 software. Results Six trails were included. Compared to photon therapy (three-dimensional conformal photon radiotherapy, 3D-CRT), the proton therapy had a significantly lower total lung Dmean (MD=-4.15, 95%CI: -5.56--2.74, P<0.001) and V20, V10, V5 (MD=-10.92, 95%CI: -13.23--8.62, P<0.001); The V20, V10, V5 significantly decreased in proton therapy group. Compared to photon therapy (intensity-modulated photon radiotherapy, IMRT), V20, V10, V5 were also significantly lowered in proton therapy group (MD=-3.70, 95%CI: -5.31--2.10, P<0.001; MD=-8.86, 95%CI: -10.74--6.98, P<0.001; MD=-20.13, 95%CI: -27.11--13.14, P<0.001); The esophagus Dmean was not lowered, while the heart Dmean decreased in proton therapy group. Conclusion Comparing to photon beam radiotherapy (3D-CRT and IMRT), proton beam therapy is advantageous in dosimetry of the lung cancer radiotherapy and recommended for clinical applying.http://dx.doi.org/10.3779/j.issn.1009-3419.2013.05.07ProtonPhotonMeta-analysisLung neoplasmsRadiotherapy |
| spellingShingle | Guangwei TIAN Nan LI Guang LI Dosimetric Comparing between Protons Beam and Photons Beam for Lung Cancer Radiotherapy: A Meta-analysis Chinese Journal of Lung Cancer Proton Photon Meta-analysis Lung neoplasms Radiotherapy |
| title | Dosimetric Comparing between Protons Beam and Photons Beam
for Lung Cancer Radiotherapy: A Meta-analysis |
| title_full | Dosimetric Comparing between Protons Beam and Photons Beam
for Lung Cancer Radiotherapy: A Meta-analysis |
| title_fullStr | Dosimetric Comparing between Protons Beam and Photons Beam
for Lung Cancer Radiotherapy: A Meta-analysis |
| title_full_unstemmed | Dosimetric Comparing between Protons Beam and Photons Beam
for Lung Cancer Radiotherapy: A Meta-analysis |
| title_short | Dosimetric Comparing between Protons Beam and Photons Beam
for Lung Cancer Radiotherapy: A Meta-analysis |
| title_sort | dosimetric comparing between protons beam and photons beam
for lung cancer radiotherapy a meta analysis |
| topic | Proton Photon Meta-analysis Lung neoplasms Radiotherapy |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2013.05.07 |
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