Weight Loss at First Month and Development of Tolerance as Possible Predictors of 30 mg Phentermine Efficacy at 6 Months
The efficacy of anti-obesity drugs usually does not consider the high degree of interindividual variability in responses to the drug which could affect the decision to withdraw the drug early due to ineffectiveness or to continue therapy according to specific expectations of success. The aim of this...
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MDPI AG
2021-12-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/11/12/1354 |
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| author | Héctor Isaac Rocha-González Lidia Elizabeth De la Cruz-Álvarez Ashuin Kammar-García Samuel Canizales-Quinteros Juan Carlos Huerta-Cruz Lina Marcela Barranco-Garduño Juan Gerardo Reyes-García |
| author_facet | Héctor Isaac Rocha-González Lidia Elizabeth De la Cruz-Álvarez Ashuin Kammar-García Samuel Canizales-Quinteros Juan Carlos Huerta-Cruz Lina Marcela Barranco-Garduño Juan Gerardo Reyes-García |
| author_sort | Héctor Isaac Rocha-González |
| collection | DOAJ |
| description | The efficacy of anti-obesity drugs usually does not consider the high degree of interindividual variability in responses to the drug which could affect the decision to withdraw the drug early due to ineffectiveness or to continue therapy according to specific expectations of success. The aim of this study was to analyze body weight loss in kilograms during the first month (1 mo-BWL<sub>kg</sub>) of treatment with 30 mg phentermine and development of tolerance to phentermine, on its 6-month efficacy. One hundred sixty-six subjects with obesity were individually or jointly analyzed in the study. Subjects with 1 mo-BWL<sub>kg</sub> of <1 kg, 1–3 kg, 3–5 kg, and ≥5 kg reached 6-month mean percentage body weight reductions (BWR%) of approximately 3%, 5%, 10%, and 15%, respectively. Development of late tolerance (4–6 months) to phentermine had a lower impact than early tolerance (2–3 months). Subjects with 1 mo-BWL<sub>kg</sub> < 3 kg who developed early tolerance did not achieve relevant BWR% (≥5%) at month 6, while the rest of the subgroups achieved increasing and progressive BWR%, according to their 1 mo-BWL<sub>kg</sub> range and time of onset of tolerance. The 1 mo-BWL<sub>kg</sub> and development of tolerance to phentermine could be useful to predict the expected 6-month efficacy trends in obese patients treated with 30 mg phentermine. |
| first_indexed | 2024-03-10T03:46:06Z |
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| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T03:46:06Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-a2f9245592fa4d718414bca7227ec3412023-11-23T09:08:22ZengMDPI AGJournal of Personalized Medicine2075-44262021-12-011112135410.3390/jpm11121354Weight Loss at First Month and Development of Tolerance as Possible Predictors of 30 mg Phentermine Efficacy at 6 MonthsHéctor Isaac Rocha-González0Lidia Elizabeth De la Cruz-Álvarez1Ashuin Kammar-García2Samuel Canizales-Quinteros3Juan Carlos Huerta-Cruz4Lina Marcela Barranco-Garduño5Juan Gerardo Reyes-García6Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, Col. Casco de Santo Tomas, Miguel Hidalgo, Mexico City 11340, MexicoSección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, Col. Casco de Santo Tomas, Miguel Hidalgo, Mexico City 11340, MexicoSección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, Col. Casco de Santo Tomas, Miguel Hidalgo, Mexico City 11340, MexicoFacultad de Química, Universidad Nacional Autónoma de México, Circuito Escolar S/N, Ciudad Universitaria, Coyoacán, Mexico City 04510, MexicoUnidad de Investigación en Farmacología, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosio Villegas, Secretaría de Salud, Calzada de Tlalpan 4502, Col. Belisario Domínguez Sección XVI, Tlalpan, Mexico City 14080, MexicoUnidad de Investigación en Farmacología, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosio Villegas, Secretaría de Salud, Calzada de Tlalpan 4502, Col. Belisario Domínguez Sección XVI, Tlalpan, Mexico City 14080, MexicoSección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, Col. Casco de Santo Tomas, Miguel Hidalgo, Mexico City 11340, MexicoThe efficacy of anti-obesity drugs usually does not consider the high degree of interindividual variability in responses to the drug which could affect the decision to withdraw the drug early due to ineffectiveness or to continue therapy according to specific expectations of success. The aim of this study was to analyze body weight loss in kilograms during the first month (1 mo-BWL<sub>kg</sub>) of treatment with 30 mg phentermine and development of tolerance to phentermine, on its 6-month efficacy. One hundred sixty-six subjects with obesity were individually or jointly analyzed in the study. Subjects with 1 mo-BWL<sub>kg</sub> of <1 kg, 1–3 kg, 3–5 kg, and ≥5 kg reached 6-month mean percentage body weight reductions (BWR%) of approximately 3%, 5%, 10%, and 15%, respectively. Development of late tolerance (4–6 months) to phentermine had a lower impact than early tolerance (2–3 months). Subjects with 1 mo-BWL<sub>kg</sub> < 3 kg who developed early tolerance did not achieve relevant BWR% (≥5%) at month 6, while the rest of the subgroups achieved increasing and progressive BWR%, according to their 1 mo-BWL<sub>kg</sub> range and time of onset of tolerance. The 1 mo-BWL<sub>kg</sub> and development of tolerance to phentermine could be useful to predict the expected 6-month efficacy trends in obese patients treated with 30 mg phentermine.https://www.mdpi.com/2075-4426/11/12/1354interindividual variabilityobesityphenterminetoleranceweight loss success |
| spellingShingle | Héctor Isaac Rocha-González Lidia Elizabeth De la Cruz-Álvarez Ashuin Kammar-García Samuel Canizales-Quinteros Juan Carlos Huerta-Cruz Lina Marcela Barranco-Garduño Juan Gerardo Reyes-García Weight Loss at First Month and Development of Tolerance as Possible Predictors of 30 mg Phentermine Efficacy at 6 Months Journal of Personalized Medicine interindividual variability obesity phentermine tolerance weight loss success |
| title | Weight Loss at First Month and Development of Tolerance as Possible Predictors of 30 mg Phentermine Efficacy at 6 Months |
| title_full | Weight Loss at First Month and Development of Tolerance as Possible Predictors of 30 mg Phentermine Efficacy at 6 Months |
| title_fullStr | Weight Loss at First Month and Development of Tolerance as Possible Predictors of 30 mg Phentermine Efficacy at 6 Months |
| title_full_unstemmed | Weight Loss at First Month and Development of Tolerance as Possible Predictors of 30 mg Phentermine Efficacy at 6 Months |
| title_short | Weight Loss at First Month and Development of Tolerance as Possible Predictors of 30 mg Phentermine Efficacy at 6 Months |
| title_sort | weight loss at first month and development of tolerance as possible predictors of 30 mg phentermine efficacy at 6 months |
| topic | interindividual variability obesity phentermine tolerance weight loss success |
| url | https://www.mdpi.com/2075-4426/11/12/1354 |
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