Changes in the superior longitudinal fasciculus and anterior thalamic radiation in the left brain are associated with developmental dyscalculia
Developmental dyscalculia is a neurodevelopmental disorder specific to arithmetic learning even with normal intelligence and age-appropriate education. Difficulties often persist from childhood through adulthood lowering the individual’s quality of life. However, the neural correlates of development...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2023.1147352/full |
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| author | Nazife Ayyıldız Nazife Ayyıldız Frauke Beyer Frauke Beyer Sertaç Üstün Sertaç Üstün Sertaç Üstün Emre H. Kale Öykü Mançe Çalışır Öykü Mançe Çalışır Pınar Uran Özgür Öner Sinan Olkun Alfred Anwander A. Veronica Witte Arno Villringer Arno Villringer Metehan Çiçek Metehan Çiçek Metehan Çiçek |
| author_facet | Nazife Ayyıldız Nazife Ayyıldız Frauke Beyer Frauke Beyer Sertaç Üstün Sertaç Üstün Sertaç Üstün Emre H. Kale Öykü Mançe Çalışır Öykü Mançe Çalışır Pınar Uran Özgür Öner Sinan Olkun Alfred Anwander A. Veronica Witte Arno Villringer Arno Villringer Metehan Çiçek Metehan Çiçek Metehan Çiçek |
| author_sort | Nazife Ayyıldız |
| collection | DOAJ |
| description | Developmental dyscalculia is a neurodevelopmental disorder specific to arithmetic learning even with normal intelligence and age-appropriate education. Difficulties often persist from childhood through adulthood lowering the individual’s quality of life. However, the neural correlates of developmental dyscalculia are poorly understood. This study aimed to identify brain structural connectivity alterations in developmental dyscalculia. All participants were recruited from a large scale, non-referred population sample in a longitudinal design. We studied 10 children with developmental dyscalculia (11.3 ± 0.7 years) and 16 typically developing peers (11.2 ± 0.6 years) using diffusion-weighted magnetic resonance imaging. We assessed white matter microstructure with tract-based spatial statistics in regions-of-interest tracts that had previously been related to math ability in children. Then we used global probabilistic tractography for the first time to measure and compare tract length between developmental dyscalculia and typically developing groups. The high angular resolution diffusion-weighted magnetic resonance imaging and crossing-fiber probabilistic tractography allowed us to evaluate the length of the pathways compared to previous studies. The major findings of our study were reduced white matter coherence and shorter tract length of the left superior longitudinal/arcuate fasciculus and left anterior thalamic radiation in the developmental dyscalculia group. Furthermore, the lower white matter coherence and shorter pathways tended to be associated with the lower math performance. These results from the regional analyses indicate that learning, memory and language-related pathways in the left hemisphere might be related to developmental dyscalculia in children. |
| first_indexed | 2024-03-11T19:48:42Z |
| format | Article |
| id | doaj.art-a2fb934bf39d4b4bb862dcb2e78a999a |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-03-11T19:48:42Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-a2fb934bf39d4b4bb862dcb2e78a999a2023-10-05T15:46:56ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612023-09-011710.3389/fnhum.2023.11473521147352Changes in the superior longitudinal fasciculus and anterior thalamic radiation in the left brain are associated with developmental dyscalculiaNazife Ayyıldız0Nazife Ayyıldız1Frauke Beyer2Frauke Beyer3Sertaç Üstün4Sertaç Üstün5Sertaç Üstün6Emre H. Kale7Öykü Mançe Çalışır8Öykü Mançe Çalışır9Pınar Uran10Özgür Öner11Sinan Olkun12Alfred Anwander13A. Veronica Witte14Arno Villringer15Arno Villringer16Metehan Çiçek17Metehan Çiçek18Metehan Çiçek19Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanyDepartment of Interdisciplinary Neuroscience, Health Sciences Institute and Brain Research Center, Ankara University, Ankara, TürkiyeDepartment of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanySubproject A1, CRC 1052 “Obesity Mechanisms”, University of Leipzig, Leipzig, GermanyDepartment of Interdisciplinary Neuroscience, Health Sciences Institute and Brain Research Center, Ankara University, Ankara, TürkiyeDepartment of Physiology, School of Medicine, Ankara University, Ankara, TürkiyeNeuroscience and Neurotechnology Center of Excellence, Ankara, TürkiyeDepartment of Interdisciplinary Neuroscience, Health Sciences Institute and Brain Research Center, Ankara University, Ankara, TürkiyeDepartment of Interdisciplinary Neuroscience, Health Sciences Institute and Brain Research Center, Ankara University, Ankara, TürkiyeProgram of Counseling and Guidance, Department of Educational Sciences, Faculty of Educational Sciences, Ankara University, Ankara, TürkiyeDepartment of Child and Adolescent Psychiatry, School of Medicine, Izmir Democracy University, Izmir, TürkiyeDepartment of Child and Adolescence Psychiatry, School of Medicine, Bahçeşehir University, Istanbul, TürkiyeDepartment of Elementary Education, Faculty of Educational Sciences, Ankara University, Ankara, Türkiye0Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanyDepartment of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanyDepartment of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany1MindBrainBody Institute, Berlin School of Mind and Brain, Charité and Humboldt University, Berlin, GermanyDepartment of Interdisciplinary Neuroscience, Health Sciences Institute and Brain Research Center, Ankara University, Ankara, TürkiyeDepartment of Physiology, School of Medicine, Ankara University, Ankara, TürkiyeNeuroscience and Neurotechnology Center of Excellence, Ankara, TürkiyeDevelopmental dyscalculia is a neurodevelopmental disorder specific to arithmetic learning even with normal intelligence and age-appropriate education. Difficulties often persist from childhood through adulthood lowering the individual’s quality of life. However, the neural correlates of developmental dyscalculia are poorly understood. This study aimed to identify brain structural connectivity alterations in developmental dyscalculia. All participants were recruited from a large scale, non-referred population sample in a longitudinal design. We studied 10 children with developmental dyscalculia (11.3 ± 0.7 years) and 16 typically developing peers (11.2 ± 0.6 years) using diffusion-weighted magnetic resonance imaging. We assessed white matter microstructure with tract-based spatial statistics in regions-of-interest tracts that had previously been related to math ability in children. Then we used global probabilistic tractography for the first time to measure and compare tract length between developmental dyscalculia and typically developing groups. The high angular resolution diffusion-weighted magnetic resonance imaging and crossing-fiber probabilistic tractography allowed us to evaluate the length of the pathways compared to previous studies. The major findings of our study were reduced white matter coherence and shorter tract length of the left superior longitudinal/arcuate fasciculus and left anterior thalamic radiation in the developmental dyscalculia group. Furthermore, the lower white matter coherence and shorter pathways tended to be associated with the lower math performance. These results from the regional analyses indicate that learning, memory and language-related pathways in the left hemisphere might be related to developmental dyscalculia in children.https://www.frontiersin.org/articles/10.3389/fnhum.2023.1147352/fullanterior thalamic radiationdiffusion-weighted magnetic resonance imagingmathematical learning disabilityprobabilistic tractographysuperior longitudinal fasciculusarithmetic and numerical abilities |
| spellingShingle | Nazife Ayyıldız Nazife Ayyıldız Frauke Beyer Frauke Beyer Sertaç Üstün Sertaç Üstün Sertaç Üstün Emre H. Kale Öykü Mançe Çalışır Öykü Mançe Çalışır Pınar Uran Özgür Öner Sinan Olkun Alfred Anwander A. Veronica Witte Arno Villringer Arno Villringer Metehan Çiçek Metehan Çiçek Metehan Çiçek Changes in the superior longitudinal fasciculus and anterior thalamic radiation in the left brain are associated with developmental dyscalculia Frontiers in Human Neuroscience anterior thalamic radiation diffusion-weighted magnetic resonance imaging mathematical learning disability probabilistic tractography superior longitudinal fasciculus arithmetic and numerical abilities |
| title | Changes in the superior longitudinal fasciculus and anterior thalamic radiation in the left brain are associated with developmental dyscalculia |
| title_full | Changes in the superior longitudinal fasciculus and anterior thalamic radiation in the left brain are associated with developmental dyscalculia |
| title_fullStr | Changes in the superior longitudinal fasciculus and anterior thalamic radiation in the left brain are associated with developmental dyscalculia |
| title_full_unstemmed | Changes in the superior longitudinal fasciculus and anterior thalamic radiation in the left brain are associated with developmental dyscalculia |
| title_short | Changes in the superior longitudinal fasciculus and anterior thalamic radiation in the left brain are associated with developmental dyscalculia |
| title_sort | changes in the superior longitudinal fasciculus and anterior thalamic radiation in the left brain are associated with developmental dyscalculia |
| topic | anterior thalamic radiation diffusion-weighted magnetic resonance imaging mathematical learning disability probabilistic tractography superior longitudinal fasciculus arithmetic and numerical abilities |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2023.1147352/full |
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