Non-selective Del Nido and St Thomas cardioplegia in adults: analysis of early clinical experience using propensity matching
Background: Del Nido cardioplegia (DNC) is a single-dose, high potassium, low-volume cardioplegia solution that has grown in favor recently. However, the use of DNC in the Asian population may be associated with certain challenges. Methods: Between January 2017 and April 2022, DNC was used for myoca...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-11-01
|
| Series: | Therapeutic Advances in Cardiovascular Disease |
| Online Access: | https://doi.org/10.1177/17539447231210713 |
| _version_ | 1797511090295275520 |
|---|---|
| author | Faizus Sazzad Zhi Xian Ong Geok Seen Ong Hai Dong Luo Si Guim Goh Theo Kofidis Sorokin Vitaly |
| author_facet | Faizus Sazzad Zhi Xian Ong Geok Seen Ong Hai Dong Luo Si Guim Goh Theo Kofidis Sorokin Vitaly |
| author_sort | Faizus Sazzad |
| collection | DOAJ |
| description | Background: Del Nido cardioplegia (DNC) is a single-dose, high potassium, low-volume cardioplegia solution that has grown in favor recently. However, the use of DNC in the Asian population may be associated with certain challenges. Methods: Between January 2017 and April 2022, DNC was used for myocardial protection in this single-center retrospective study. In total, 5731 patients underwent open heart surgeries, where 310 patients received DNC for single or multiple procedures. A total of 307 pair of propensity-matched patients from DNC and cold blood St. Thomas cardioplegia (STC) were compared. Results: In total, 5085 patients with STC and 310 patients with DNC from the cohort were matched, reflecting the initial group sizes before propensity matching. About 307 patient pairs were included in the final analysis after propensity matching with the interest variables. In the STC group, the requirement for an immediate postoperative intra-aortic balloon pump (IABP) was significantly higher [18 (5.9%) in DNC versus 28 (9.1%) in STC, p = 0.021]. A 30-day mortality was comparable between the DNC and STC groups (2.9% versus 3.3%, p = 1.00). Major adverse cardiac events (MACE) (2.6% versus 3.6%, p = 0.648) showed no difference between the groups. In both single and multiple procedure subgroups, there were no statistically significant differences in 30-day mortality and MACE incidences when comparing STC and DNC. Conclusion: The use of DNC in adults is acceptable and adaptable. Comparable clinical outcomes between STC patients and DNC were revealed by our investigation. There were no appreciable differences in 30-day mortality or MACE despite the STC group having a much higher need for immediate postoperative IABP. |
| first_indexed | 2024-03-10T05:40:29Z |
| format | Article |
| id | doaj.art-a2fc07b54acb4fc79487e0bccb05ca83 |
| institution | Directory Open Access Journal |
| issn | 1753-9455 |
| language | English |
| last_indexed | 2024-03-10T05:40:29Z |
| publishDate | 2023-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Cardiovascular Disease |
| spelling | doaj.art-a2fc07b54acb4fc79487e0bccb05ca832023-11-22T22:33:55ZengSAGE PublishingTherapeutic Advances in Cardiovascular Disease1753-94552023-11-011710.1177/17539447231210713Non-selective Del Nido and St Thomas cardioplegia in adults: analysis of early clinical experience using propensity matchingFaizus SazzadZhi Xian OngGeok Seen OngHai Dong LuoSi Guim GohTheo KofidisSorokin VitalyBackground: Del Nido cardioplegia (DNC) is a single-dose, high potassium, low-volume cardioplegia solution that has grown in favor recently. However, the use of DNC in the Asian population may be associated with certain challenges. Methods: Between January 2017 and April 2022, DNC was used for myocardial protection in this single-center retrospective study. In total, 5731 patients underwent open heart surgeries, where 310 patients received DNC for single or multiple procedures. A total of 307 pair of propensity-matched patients from DNC and cold blood St. Thomas cardioplegia (STC) were compared. Results: In total, 5085 patients with STC and 310 patients with DNC from the cohort were matched, reflecting the initial group sizes before propensity matching. About 307 patient pairs were included in the final analysis after propensity matching with the interest variables. In the STC group, the requirement for an immediate postoperative intra-aortic balloon pump (IABP) was significantly higher [18 (5.9%) in DNC versus 28 (9.1%) in STC, p = 0.021]. A 30-day mortality was comparable between the DNC and STC groups (2.9% versus 3.3%, p = 1.00). Major adverse cardiac events (MACE) (2.6% versus 3.6%, p = 0.648) showed no difference between the groups. In both single and multiple procedure subgroups, there were no statistically significant differences in 30-day mortality and MACE incidences when comparing STC and DNC. Conclusion: The use of DNC in adults is acceptable and adaptable. Comparable clinical outcomes between STC patients and DNC were revealed by our investigation. There were no appreciable differences in 30-day mortality or MACE despite the STC group having a much higher need for immediate postoperative IABP.https://doi.org/10.1177/17539447231210713 |
| spellingShingle | Faizus Sazzad Zhi Xian Ong Geok Seen Ong Hai Dong Luo Si Guim Goh Theo Kofidis Sorokin Vitaly Non-selective Del Nido and St Thomas cardioplegia in adults: analysis of early clinical experience using propensity matching Therapeutic Advances in Cardiovascular Disease |
| title | Non-selective Del Nido and St Thomas cardioplegia in adults: analysis of early clinical experience using propensity matching |
| title_full | Non-selective Del Nido and St Thomas cardioplegia in adults: analysis of early clinical experience using propensity matching |
| title_fullStr | Non-selective Del Nido and St Thomas cardioplegia in adults: analysis of early clinical experience using propensity matching |
| title_full_unstemmed | Non-selective Del Nido and St Thomas cardioplegia in adults: analysis of early clinical experience using propensity matching |
| title_short | Non-selective Del Nido and St Thomas cardioplegia in adults: analysis of early clinical experience using propensity matching |
| title_sort | non selective del nido and st thomas cardioplegia in adults analysis of early clinical experience using propensity matching |
| url | https://doi.org/10.1177/17539447231210713 |
| work_keys_str_mv | AT faizussazzad nonselectivedelnidoandstthomascardioplegiainadultsanalysisofearlyclinicalexperienceusingpropensitymatching AT zhixianong nonselectivedelnidoandstthomascardioplegiainadultsanalysisofearlyclinicalexperienceusingpropensitymatching AT geokseenong nonselectivedelnidoandstthomascardioplegiainadultsanalysisofearlyclinicalexperienceusingpropensitymatching AT haidongluo nonselectivedelnidoandstthomascardioplegiainadultsanalysisofearlyclinicalexperienceusingpropensitymatching AT siguimgoh nonselectivedelnidoandstthomascardioplegiainadultsanalysisofearlyclinicalexperienceusingpropensitymatching AT theokofidis nonselectivedelnidoandstthomascardioplegiainadultsanalysisofearlyclinicalexperienceusingpropensitymatching AT sorokinvitaly nonselectivedelnidoandstthomascardioplegiainadultsanalysisofearlyclinicalexperienceusingpropensitymatching |