Tumour‐derived transforming growth factor‐β signalling contributes to fibrosis in patients with cancer cachexia

Tumour‐derived transforming growth factor‐β signalling contributes to fibrosis in patients with cancer cachexia

Abstract Background Cachexia is a paraneoplastic syndrome related with poor prognosis. The tumour micro‐environment contributes to systemic inflammation and increased oxidative stress as well as to fibrosis. The aim of the present study was to characterise the inflammatory circulating factors and tu...

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Main Authors: Joanna D.C.C. Lima, Estefania Simoes, Gabriela deCastro, Mychel Raony P.T. Morais, Emidio M. deMatos‐Neto, Michele J. Alves, Nelson I. Pinto, Raquel G. Figueredo, Telma M.T. Zorn, Aloísio S. Felipe‐Silva, Flavio Tokeshi, José P. Otoch, Paulo Alcantara, Fernanda J. Cabral, Emer S. Ferro, Alessandro Laviano, Marilia Seelaender
Format: Article
Language:English
Published: Wiley 2019-10-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Tumour micro‐environment
Cachexia
Epithelial–mesenchymal components
Fibrosis
Online Access:https://doi.org/10.1002/jcsm.12441

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