Study of Skin Barrier Function in Psoriasis: The Impact of Emollients
Psoriasis is a chronic multi-systemic inflammatory disease that affects the epidermal barrier. Emollients can be used as a coadjutant therapy for psoriasis management, but little is known about how the epidermal barrier function in psoriatic patients is modified by moisturizers. The objective of thi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/11/7/651 |
| _version_ | 1797526807205904384 |
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| author | Daniel Maroto-Morales Trinidad Montero-Vilchez Salvador Arias-Santiago |
| author_facet | Daniel Maroto-Morales Trinidad Montero-Vilchez Salvador Arias-Santiago |
| author_sort | Daniel Maroto-Morales |
| collection | DOAJ |
| description | Psoriasis is a chronic multi-systemic inflammatory disease that affects the epidermal barrier. Emollients can be used as a coadjutant therapy for psoriasis management, but little is known about how the epidermal barrier function in psoriatic patients is modified by moisturizers. The objective of this study is to evaluate the effect of Vaseline jelly and a water-based formula on epidermal barrier function in psoriatic patients. Thirty-one patients with plaque-type psoriasis and thirty-one gender and age-matched healthy controls were enrolled in the study. Temperature, transepidermal water loss (TEWL), stratum corneum hydration (SCH), pH, elasticity and the erythema index were measured using non-invasive tools before and after applying Vaseline jelly and a water-based formula. TEWL was higher in psoriatic plaques than uninvolved psoriatic skin (13.23 vs. 8.54 g·m<sup>−2</sup>·h<sup>−1</sup>; <i>p</i> < 0.001). SCH was lower in psoriatic plaques than uninvolved psoriatic skin and healthy skin (13.44 vs. 30.55 vs. 30.90 arbitrary units (AU), <i>p</i> < 0.001). In psoriatic plaques, TEWL decreased by 5.59 g·m<sup>−2</sup>·h<sup>−1</sup> (<i>p</i> = 0.001) after applying Vaseline Jelly, while it increased by 3.60 g·m<sup>−2</sup>·h<sup>−1</sup> (<i>p</i> = 0.006) after applying the water-based formula. SCH increased by 9.44 AU after applying the water-based formula (<i>p</i> = 0.003). The use of emollients may improve epidermal barrier function in psoriatic patients. TEWL is decreased by using Vaseline, and SCH is increased by using the water-based formula. |
| first_indexed | 2024-03-10T09:34:32Z |
| format | Article |
| id | doaj.art-a2fd0f4f7d5e4aee9285ab46a7ca88ac |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T09:34:32Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-a2fd0f4f7d5e4aee9285ab46a7ca88ac2023-11-22T04:12:35ZengMDPI AGLife2075-17292021-07-0111765110.3390/life11070651Study of Skin Barrier Function in Psoriasis: The Impact of EmollientsDaniel Maroto-Morales0Trinidad Montero-Vilchez1Salvador Arias-Santiago2Dermatology Department, Faculty of Medicine, University of Granada, 18071 Granada, SpainDepartment of Dermatology at Hospital Universitario Virgen de las Nieves, 18012 Granada, SpainDermatology Department, Faculty of Medicine, University of Granada, 18071 Granada, SpainPsoriasis is a chronic multi-systemic inflammatory disease that affects the epidermal barrier. Emollients can be used as a coadjutant therapy for psoriasis management, but little is known about how the epidermal barrier function in psoriatic patients is modified by moisturizers. The objective of this study is to evaluate the effect of Vaseline jelly and a water-based formula on epidermal barrier function in psoriatic patients. Thirty-one patients with plaque-type psoriasis and thirty-one gender and age-matched healthy controls were enrolled in the study. Temperature, transepidermal water loss (TEWL), stratum corneum hydration (SCH), pH, elasticity and the erythema index were measured using non-invasive tools before and after applying Vaseline jelly and a water-based formula. TEWL was higher in psoriatic plaques than uninvolved psoriatic skin (13.23 vs. 8.54 g·m<sup>−2</sup>·h<sup>−1</sup>; <i>p</i> < 0.001). SCH was lower in psoriatic plaques than uninvolved psoriatic skin and healthy skin (13.44 vs. 30.55 vs. 30.90 arbitrary units (AU), <i>p</i> < 0.001). In psoriatic plaques, TEWL decreased by 5.59 g·m<sup>−2</sup>·h<sup>−1</sup> (<i>p</i> = 0.001) after applying Vaseline Jelly, while it increased by 3.60 g·m<sup>−2</sup>·h<sup>−1</sup> (<i>p</i> = 0.006) after applying the water-based formula. SCH increased by 9.44 AU after applying the water-based formula (<i>p</i> = 0.003). The use of emollients may improve epidermal barrier function in psoriatic patients. TEWL is decreased by using Vaseline, and SCH is increased by using the water-based formula.https://www.mdpi.com/2075-1729/11/7/651emollientshomeostasismoisturizerspsoriasisskin physiologyskin barrier |
| spellingShingle | Daniel Maroto-Morales Trinidad Montero-Vilchez Salvador Arias-Santiago Study of Skin Barrier Function in Psoriasis: The Impact of Emollients Life emollients homeostasis moisturizers psoriasis skin physiology skin barrier |
| title | Study of Skin Barrier Function in Psoriasis: The Impact of Emollients |
| title_full | Study of Skin Barrier Function in Psoriasis: The Impact of Emollients |
| title_fullStr | Study of Skin Barrier Function in Psoriasis: The Impact of Emollients |
| title_full_unstemmed | Study of Skin Barrier Function in Psoriasis: The Impact of Emollients |
| title_short | Study of Skin Barrier Function in Psoriasis: The Impact of Emollients |
| title_sort | study of skin barrier function in psoriasis the impact of emollients |
| topic | emollients homeostasis moisturizers psoriasis skin physiology skin barrier |
| url | https://www.mdpi.com/2075-1729/11/7/651 |
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