Common Factors Underlying Diverse Responses in Alcohol Use Disorder
Objective Interindividual variation in responses to alcohol is substantial, posing challenges for medical management and for understanding the biological underpinnings of alcohol use disorders (AUD). It is important to understand whether diverse alcohol responses such as sedation, which is predictiv...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-06-01
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| Series: | Psychiatric Research and Clinical Practice |
| Online Access: | https://doi.org/10.1176/appi.prcp.20200028 |
| _version_ | 1818448657547001856 |
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| author | Esha Chebolu Melanie L. Schwandt Vijay A. Ramchandani Bethany L. Stangl David T. George Yvonne Horneffer Tonette Vinson Emily L. Vogt Brandon A. Manor Nancy Diazgranados David Goldman |
| author_facet | Esha Chebolu Melanie L. Schwandt Vijay A. Ramchandani Bethany L. Stangl David T. George Yvonne Horneffer Tonette Vinson Emily L. Vogt Brandon A. Manor Nancy Diazgranados David Goldman |
| author_sort | Esha Chebolu |
| collection | DOAJ |
| description | Objective Interindividual variation in responses to alcohol is substantial, posing challenges for medical management and for understanding the biological underpinnings of alcohol use disorders (AUD). It is important to understand whether diverse alcohol responses such as sedation, which is predictive of risk and partly heritable, occur concurrently or independently from responses such as blackouts and withdrawal. We hypothesized that latent factors accounting for sources of variance in diverse alcohol response phenotypes could be identified in a large, deeply phenotyped sample of patients with AUD. Methods We factor analyzed 17 alcohol response related items from the Alcohol Dependence Scale (ADS) in 938 individuals diagnosed with AUD via structured clinical interviews. Demographic, genetic, and clinical characteristics were tested as predictors of the latent factors by multiple indicators, multiple causes analysis. Results The final factor solution included three alcohol response factors: Physical Symptoms, Perceptual Disturbances, and Neurobiological Effects. Both gender and genetic ancestry were identified as variables influencing alcohol response. Major depressive disorder positively predicted physical symptoms and aggression negatively predicted physical symptoms. Barratt's Impulsivity Scale total score predicted the Physical and Perceptual domains. Family history, average drinks per drinking day, and negative urgency (an impulsivity measure) predicted all three domains. Conclusions Diverse items from the ADS concurrently load onto three correlated alcohol response factors rather than loading independently. Genetic ancestry and clinical characteristics predicted the severity of items that define the alcohol response factors even after accounting for degree of alcohol consumption. Co‐occurring phenotypes point towards an underlying shared physiology of diverse alcohol responses. |
| first_indexed | 2024-12-14T20:23:00Z |
| format | Article |
| id | doaj.art-a2fd4a4b83f4451bb6bc4d82d9356295 |
| institution | Directory Open Access Journal |
| issn | 2575-5609 |
| language | English |
| last_indexed | 2024-12-14T20:23:00Z |
| publishDate | 2021-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Psychiatric Research and Clinical Practice |
| spelling | doaj.art-a2fd4a4b83f4451bb6bc4d82d93562952022-12-21T22:48:42ZengWileyPsychiatric Research and Clinical Practice2575-56092021-06-0132768710.1176/appi.prcp.20200028Common Factors Underlying Diverse Responses in Alcohol Use DisorderEsha Chebolu0Melanie L. Schwandt1Vijay A. Ramchandani2Bethany L. Stangl3David T. George4Yvonne Horneffer5Tonette Vinson6Emily L. Vogt7Brandon A. Manor8Nancy Diazgranados9David Goldman10Office of the Clinical Director Laboratory of Neurogenetics NIAAA Bethesda MDOffice of the Clinical Director NIAAA Bethesda MDSection on Human Psychopharmacology NIAAA Bethesda MDSection on Human Psychopharmacology NIAAA Bethesda MDOffice of the Clinical Director NIAAA Bethesda MDOffice of the Clinical Director NIAAA Bethesda MDOffice of the Clinical Director NIAAA Bethesda MDUniversity of Michigan Medical School Ann Arbor MIOffice of the Clinical Director NIAAA Bethesda MDOffice of the Clinical Director NIAAA Bethesda MDOffice of the Clinical Director Laboratory of Neurogenetics NIAAA Bethesda MDObjective Interindividual variation in responses to alcohol is substantial, posing challenges for medical management and for understanding the biological underpinnings of alcohol use disorders (AUD). It is important to understand whether diverse alcohol responses such as sedation, which is predictive of risk and partly heritable, occur concurrently or independently from responses such as blackouts and withdrawal. We hypothesized that latent factors accounting for sources of variance in diverse alcohol response phenotypes could be identified in a large, deeply phenotyped sample of patients with AUD. Methods We factor analyzed 17 alcohol response related items from the Alcohol Dependence Scale (ADS) in 938 individuals diagnosed with AUD via structured clinical interviews. Demographic, genetic, and clinical characteristics were tested as predictors of the latent factors by multiple indicators, multiple causes analysis. Results The final factor solution included three alcohol response factors: Physical Symptoms, Perceptual Disturbances, and Neurobiological Effects. Both gender and genetic ancestry were identified as variables influencing alcohol response. Major depressive disorder positively predicted physical symptoms and aggression negatively predicted physical symptoms. Barratt's Impulsivity Scale total score predicted the Physical and Perceptual domains. Family history, average drinks per drinking day, and negative urgency (an impulsivity measure) predicted all three domains. Conclusions Diverse items from the ADS concurrently load onto three correlated alcohol response factors rather than loading independently. Genetic ancestry and clinical characteristics predicted the severity of items that define the alcohol response factors even after accounting for degree of alcohol consumption. Co‐occurring phenotypes point towards an underlying shared physiology of diverse alcohol responses.https://doi.org/10.1176/appi.prcp.20200028 |
| spellingShingle | Esha Chebolu Melanie L. Schwandt Vijay A. Ramchandani Bethany L. Stangl David T. George Yvonne Horneffer Tonette Vinson Emily L. Vogt Brandon A. Manor Nancy Diazgranados David Goldman Common Factors Underlying Diverse Responses in Alcohol Use Disorder Psychiatric Research and Clinical Practice |
| title | Common Factors Underlying Diverse Responses in Alcohol Use Disorder |
| title_full | Common Factors Underlying Diverse Responses in Alcohol Use Disorder |
| title_fullStr | Common Factors Underlying Diverse Responses in Alcohol Use Disorder |
| title_full_unstemmed | Common Factors Underlying Diverse Responses in Alcohol Use Disorder |
| title_short | Common Factors Underlying Diverse Responses in Alcohol Use Disorder |
| title_sort | common factors underlying diverse responses in alcohol use disorder |
| url | https://doi.org/10.1176/appi.prcp.20200028 |
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