Incidence of hepatocellular carcinoma in hepatitis C cirrhotic patients with and without HIV infection: a cohort study, 1999-2011
Introduction. High activity antiretroviral therapy (HAART) has allowed people infected with human immunodeficiency virus (HIV) to live longer. In the course of time, hepatocellular carcinoma (HCC) began to be found in these patients. Investigations have suggested that, as it has been described for o...
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Elsevier
2014-01-01
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| Series: | Annals of Hepatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268119309020 |
| _version_ | 1818608183000694784 |
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| author | Nicolas Di Benedetto Mirta Peralta Estela Alvarez María Teresa Schroder Claudio Estepo Silvia Paz Hugo Fainboim |
| author_facet | Nicolas Di Benedetto Mirta Peralta Estela Alvarez María Teresa Schroder Claudio Estepo Silvia Paz Hugo Fainboim |
| author_sort | Nicolas Di Benedetto |
| collection | DOAJ |
| description | Introduction. High activity antiretroviral therapy (HAART) has allowed people infected with human immunodeficiency virus (HIV) to live longer. In the course of time, hepatocellular carcinoma (HCC) began to be found in these patients. Investigations have suggested that, as it has been described for other tumors, HIV infection raises the risk of developing HCC. However, convincing evidence is still required. Our aim was to quantify the incidence of HCC in hepatitis C cirrhotic patients with and without human immunodeficiency virus infection in the HAART era.Material and methods. This prospective cohort study was conducted in hepatitis C cirrhotic patients with and without HIV co-infection, between june 1, 1999 and May 21, 2010. Ultrasound screening for HCC was performed every 6 to 12 months to all the patients until January 15, 2011. Incidence rate and cumulative incidence (Kaplan-Meier) were calculated.Results. One hundred and forty eight patients (69 hepatitis C virus mono-infected and 79 HIV/hepatitis C virus co-infected) were followed for a median time of 43 months, with a total follow-up of 555 person-years (324 for co-infected and 231 for mono-infected patients). Twelve patients developed HCC (5 co-infected and 7 mono-infected). The incidence of HCC in co-infected patients and mono-infected patients was 1.54 (95% confidence interval = 0.5 to 3.6) and 3.03 (95% confidence interval = 1.22 to 6.23) cases per 100 person-year respectively (log-rank p = 0.3225).Conclusion. In the HAART era, HIV co-infection is not associated with a higher incidence of HCC in hepatitis C cirrhotic patients. |
| first_indexed | 2024-12-16T14:38:35Z |
| format | Article |
| id | doaj.art-a2fd6018e940436780c7c2b0262da3cb |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-12-16T14:38:35Z |
| publishDate | 2014-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-a2fd6018e940436780c7c2b0262da3cb2022-12-21T22:28:02ZengElsevierAnnals of Hepatology1665-26812014-01-011313844Incidence of hepatocellular carcinoma in hepatitis C cirrhotic patients with and without HIV infection: a cohort study, 1999-2011Nicolas Di Benedetto0Mirta Peralta1Estela Alvarez2María Teresa Schroder3Claudio Estepo4Silvia Paz5Hugo Fainboim6Hospital Muñiz, Liver Diseases, Buenos Aires, Argentina.; Correspondence and reprint request:Hospital Muñiz, Liver Diseases, Buenos Aires, Argentina.Hospital Posadas, Pathology, Buenos Aires, Argentina.Hospital Muñiz, Liver Diseases, Buenos Aires, Argentina.Hospital Muñiz, Liver Diseases, Buenos Aires, Argentina.Hospital Muñiz, Liver Diseases, Buenos Aires, Argentina.Hospital Muñiz, Liver Diseases, Buenos Aires, Argentina.Introduction. High activity antiretroviral therapy (HAART) has allowed people infected with human immunodeficiency virus (HIV) to live longer. In the course of time, hepatocellular carcinoma (HCC) began to be found in these patients. Investigations have suggested that, as it has been described for other tumors, HIV infection raises the risk of developing HCC. However, convincing evidence is still required. Our aim was to quantify the incidence of HCC in hepatitis C cirrhotic patients with and without human immunodeficiency virus infection in the HAART era.Material and methods. This prospective cohort study was conducted in hepatitis C cirrhotic patients with and without HIV co-infection, between june 1, 1999 and May 21, 2010. Ultrasound screening for HCC was performed every 6 to 12 months to all the patients until January 15, 2011. Incidence rate and cumulative incidence (Kaplan-Meier) were calculated.Results. One hundred and forty eight patients (69 hepatitis C virus mono-infected and 79 HIV/hepatitis C virus co-infected) were followed for a median time of 43 months, with a total follow-up of 555 person-years (324 for co-infected and 231 for mono-infected patients). Twelve patients developed HCC (5 co-infected and 7 mono-infected). The incidence of HCC in co-infected patients and mono-infected patients was 1.54 (95% confidence interval = 0.5 to 3.6) and 3.03 (95% confidence interval = 1.22 to 6.23) cases per 100 person-year respectively (log-rank p = 0.3225).Conclusion. In the HAART era, HIV co-infection is not associated with a higher incidence of HCC in hepatitis C cirrhotic patients.http://www.sciencedirect.com/science/article/pii/S1665268119309020Liver neoplasmsLiver cirrhosisEpidemiology |
| spellingShingle | Nicolas Di Benedetto Mirta Peralta Estela Alvarez María Teresa Schroder Claudio Estepo Silvia Paz Hugo Fainboim Incidence of hepatocellular carcinoma in hepatitis C cirrhotic patients with and without HIV infection: a cohort study, 1999-2011 Annals of Hepatology Liver neoplasms Liver cirrhosis Epidemiology |
| title | Incidence of hepatocellular carcinoma in hepatitis C cirrhotic patients with and without HIV infection: a cohort study, 1999-2011 |
| title_full | Incidence of hepatocellular carcinoma in hepatitis C cirrhotic patients with and without HIV infection: a cohort study, 1999-2011 |
| title_fullStr | Incidence of hepatocellular carcinoma in hepatitis C cirrhotic patients with and without HIV infection: a cohort study, 1999-2011 |
| title_full_unstemmed | Incidence of hepatocellular carcinoma in hepatitis C cirrhotic patients with and without HIV infection: a cohort study, 1999-2011 |
| title_short | Incidence of hepatocellular carcinoma in hepatitis C cirrhotic patients with and without HIV infection: a cohort study, 1999-2011 |
| title_sort | incidence of hepatocellular carcinoma in hepatitis c cirrhotic patients with and without hiv infection a cohort study 1999 2011 |
| topic | Liver neoplasms Liver cirrhosis Epidemiology |
| url | http://www.sciencedirect.com/science/article/pii/S1665268119309020 |
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