FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner

FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner

Introduction: Liver fibrosis is a life-threatening pathological anomaly which usually evolves into advanced liver cirrhosis and hepatocellular carcinoma although limited therapeutic option is readily available. FUN14 domain containing 1 (FUNDC1) is a mitophagy receptor with little information in liv...

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Bibliographic Details
Main Authors: Yaguang Bi, Shuolin Liu, Xing Qin, Miyesaier Abudureyimu, Lu Wang, Rongjun Zou, Amir Ajoolabady, Wenjing Zhang, Hu Peng, Jun Ren, Yingmei Zhang
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Journal of Advanced Research
Subjects:
Liver fibrosis
FUNDC1
GPx4
Mitophagy
Ferroptosis
TOM/TIM complex
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123223000632

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