Isolation and Characterization of an Unknown Process-Related Impurity in Furosemide and Validation of a New HPLC Method

Isolation and Characterization of an Unknown Process-Related Impurity in Furosemide and Validation of a New HPLC Method

Furosemide is a widely used loop diuretic in the treatment of congestive heart failure and edema. During the preparation of furosemide, a new process-related impurity G in the levels ranging from 0.08% to 0.13% was detected in pilot batches by a new high performance liquid chromatography (HPLC) meth...

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Bibliographic Details
Main Authors: Ao Xu, Yunlin Xue, Yuyu Zeng, Jing Li, Huiling Zhou, Zhen Wang, Yin Chen, Hui Chen, Jian Jin, Tao Zhuang
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Molecules
Subjects:
furosemide
process-related impurity
characterization
Q-TOF/LC–MS and NMR
method validation
Online Access:https://www.mdpi.com/1420-3049/28/5/2415

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