Metaplastic Breast Cancer with Chondroid Differentiation
Background: Metaplastic breast cancer (MBC) cancer is a rare subtype of breast carcinoma and carries a worse prognosis. Chondroid differentiation is the rarest among all its histologic subtypes. We report a case of MBC with chondroid differentiation and review its clinicopathological details, geneti...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Kaviani Breast Disease Institute
2021-07-01
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| Series: | Archives of Breast Cancer |
| Subjects: | |
| Online Access: | https://www.archbreastcancer.com/index.php/abc/article/view/357 |
| _version_ | 1818379446234644480 |
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| author | Garima Daga Rajeev Kumar |
| author_facet | Garima Daga Rajeev Kumar |
| author_sort | Garima Daga |
| collection | DOAJ |
| description | Background: Metaplastic breast cancer (MBC) cancer is a rare subtype of breast carcinoma and carries a worse prognosis. Chondroid differentiation is the rarest among all its histologic subtypes. We report a case of MBC with chondroid differentiation and review its clinicopathological details, genetic basis, and management.
Case presentation: A 56-year female presented with right-sided large breast lump. She noticed this lump 4 months before presenting. Trucut biopsy was suggestive of invasive ductal carcinoma. She underwent breast conservation surgery and histology was consistent with MBC with chondroid differentiation, pT2N3aM0. Tumour was triple-negative for ER, PR, and Her-2- neu receptors. Adjuvant treatment with chemotherapy followed by radiotherapy was given and she has been doing fine during 11 months of follow-up.
Conclusion: The MBC is an uncommon subtype with heterogeneity in biological and morphological features and its knowledge is paramount while evaluating a breast lump. Understanding the pathologic and molecular basis is imperative in developing the targeted therapy to improve outcomes. |
| first_indexed | 2024-12-14T02:02:55Z |
| format | Article |
| id | doaj.art-a2fe7124aa2942528345620431f7ac84 |
| institution | Directory Open Access Journal |
| issn | 2383-0433 |
| language | English |
| last_indexed | 2024-12-14T02:02:55Z |
| publishDate | 2021-07-01 |
| publisher | Kaviani Breast Disease Institute |
| record_format | Article |
| series | Archives of Breast Cancer |
| spelling | doaj.art-a2fe7124aa2942528345620431f7ac842022-12-21T23:20:57ZengKaviani Breast Disease InstituteArchives of Breast Cancer2383-04332021-07-0110.32768/abc.202183251-254Metaplastic Breast Cancer with Chondroid DifferentiationGarima Daga0Rajeev Kumar1Department of Surgical Oncology, Rajiv Gandhi Cancer Institute, New Delhi, IndiaDepartment of Surgical Oncology, Rajiv Gandhi Cancer Institute, New Delhi, IndiaBackground: Metaplastic breast cancer (MBC) cancer is a rare subtype of breast carcinoma and carries a worse prognosis. Chondroid differentiation is the rarest among all its histologic subtypes. We report a case of MBC with chondroid differentiation and review its clinicopathological details, genetic basis, and management. Case presentation: A 56-year female presented with right-sided large breast lump. She noticed this lump 4 months before presenting. Trucut biopsy was suggestive of invasive ductal carcinoma. She underwent breast conservation surgery and histology was consistent with MBC with chondroid differentiation, pT2N3aM0. Tumour was triple-negative for ER, PR, and Her-2- neu receptors. Adjuvant treatment with chemotherapy followed by radiotherapy was given and she has been doing fine during 11 months of follow-up. Conclusion: The MBC is an uncommon subtype with heterogeneity in biological and morphological features and its knowledge is paramount while evaluating a breast lump. Understanding the pathologic and molecular basis is imperative in developing the targeted therapy to improve outcomes.https://www.archbreastcancer.com/index.php/abc/article/view/357Metaplastic Breast CancerChondroid DifferentiationTriple negative breast cancer |
| spellingShingle | Garima Daga Rajeev Kumar Metaplastic Breast Cancer with Chondroid Differentiation Archives of Breast Cancer Metaplastic Breast Cancer Chondroid Differentiation Triple negative breast cancer |
| title | Metaplastic Breast Cancer with Chondroid Differentiation |
| title_full | Metaplastic Breast Cancer with Chondroid Differentiation |
| title_fullStr | Metaplastic Breast Cancer with Chondroid Differentiation |
| title_full_unstemmed | Metaplastic Breast Cancer with Chondroid Differentiation |
| title_short | Metaplastic Breast Cancer with Chondroid Differentiation |
| title_sort | metaplastic breast cancer with chondroid differentiation |
| topic | Metaplastic Breast Cancer Chondroid Differentiation Triple negative breast cancer |
| url | https://www.archbreastcancer.com/index.php/abc/article/view/357 |
| work_keys_str_mv | AT garimadaga metaplasticbreastcancerwithchondroiddifferentiation AT rajeevkumar metaplasticbreastcancerwithchondroiddifferentiation |