Primary lacrimal sac lymphoma: a case-based retrospective study in a Chinese population
AIM: To determine the clinical characteristics, pathological types, tumor markers, treatments, and outcomes of Chinese patients with primary lacrimal sac lymphoma. METHODS: This case-based retrospective study analyzed 15 Chinese patients with primary lacrimal sac lymphoma. The clinical data collecte...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2023-04-01
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| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/en_publish/2023/4/20230406.pdf |
| _version_ | 1797853468113764352 |
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| author | Fang Bai Hai Tao Xi-Bin Zhou Fei Wang Peng Wang Li-Hua Wang Hong-Yang Zhang |
| author_facet | Fang Bai Hai Tao Xi-Bin Zhou Fei Wang Peng Wang Li-Hua Wang Hong-Yang Zhang |
| author_sort | Fang Bai |
| collection | DOAJ |
| description | AIM: To determine the clinical characteristics, pathological types, tumor markers, treatments, and outcomes of Chinese patients with primary lacrimal sac lymphoma. METHODS: This case-based retrospective study analyzed 15 Chinese patients with primary lacrimal sac lymphoma. The clinical data collected included gender, age at diagnosis, symptoms, imaging examination results, pathologic diagnosis, pathogen identification, tumor markers, treatments, follow-up, and prognosis. Descriptive statistics were used to characterize the patients. Progression-free survival (PFS) was defined as the time from surgery to the last follow-up, first record of tumor recurrence, or death. RESULTS: There were 7 males and 8 females with unilateral primary lacrimal sac lymphoma in the left eye (n=6) or right eye (n=9). The initial symptom in 13 patients was epiphora, and 2 patients had redness and swelling in the lacrimal sac area. All patients ultimately developed epiphora, and 12 had masses in the lacrimal sac area. Analysis of preoperative plasma tumor markers indicated 14 patients had elevated homocysteine, 9 had elevated β2-microglobulin, and 2 had elevated lactate dehydrogenase (LDH); 2 patients had elevations of all three markers, and 1 patient had no elevation of any marker. All patients underwent surgical resection and 12 patients received postoperative chemotherapy. The pathological types were DLBCL (n=8), MALT lymphoma (n=5), and NK/T-cell lymphoma, nasal type (n=2). The mean follow-up time was 25.8mo (range: 4-41) and 2 patients died. Seven patients who underwent mass excision combined with dacryocystorhinostomy (DCR) had no postoperative epiphora. Eight patients who only underwent mass excision had varying degrees of postoperative epiphora. Preoperative LDH elevation and NK/T-cell lymphoma, nasal type were associated with poor prognoses. CONCLUSION: Early diagnosis and treatment can lead to a good prognosis for most patients with primary lacrimal sac lymphoma. Mass resection combined with DCR can reduce the occurrence of post-surgical epiphora. The pathology type and tumor marker status are associated with prognosis. |
| first_indexed | 2024-04-09T19:51:06Z |
| format | Article |
| id | doaj.art-a2fe8c8523e343c5bcf242322c30f02c |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-04-09T19:51:06Z |
| publishDate | 2023-04-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-a2fe8c8523e343c5bcf242322c30f02c2023-04-03T06:59:56ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982023-04-0116453253810.18240/ijo.2023.04.0620230406Primary lacrimal sac lymphoma: a case-based retrospective study in a Chinese populationFang Bai0Hai Tao1Xi-Bin Zhou2Fei Wang3Peng Wang4Li-Hua Wang5Hong-Yang Zhang6Hai Tao. The Lacrimal Center, the Senior Department of Ophthalmology, the Third Medical Center of Chinese PLA General Hospital, 69 Yongding Road, Haidian District, Beijing 100039, China. taohaiwj@sina.comThe Lacrimal Center, the Senior Department of Ophthalmology, the Third Medical Center of Chinese PLA General Hospital, Beijing 100039, ChinaThe Lacrimal Center, the Senior Department of Ophthalmology, the Third Medical Center of Chinese PLA General Hospital, Beijing 100039, ChinaThe Lacrimal Center, the Senior Department of Ophthalmology, the Third Medical Center of Chinese PLA General Hospital, Beijing 100039, ChinaThe Lacrimal Center, the Senior Department of Ophthalmology, the Third Medical Center of Chinese PLA General Hospital, Beijing 100039, ChinaThe Lacrimal Center, the Senior Department of Ophthalmology, the Third Medical Center of Chinese PLA General Hospital, Beijing 100039, ChinaThe Lacrimal Center, the Senior Department of Ophthalmology, the Third Medical Center of Chinese PLA General Hospital, Beijing 100039, ChinaAIM: To determine the clinical characteristics, pathological types, tumor markers, treatments, and outcomes of Chinese patients with primary lacrimal sac lymphoma. METHODS: This case-based retrospective study analyzed 15 Chinese patients with primary lacrimal sac lymphoma. The clinical data collected included gender, age at diagnosis, symptoms, imaging examination results, pathologic diagnosis, pathogen identification, tumor markers, treatments, follow-up, and prognosis. Descriptive statistics were used to characterize the patients. Progression-free survival (PFS) was defined as the time from surgery to the last follow-up, first record of tumor recurrence, or death. RESULTS: There were 7 males and 8 females with unilateral primary lacrimal sac lymphoma in the left eye (n=6) or right eye (n=9). The initial symptom in 13 patients was epiphora, and 2 patients had redness and swelling in the lacrimal sac area. All patients ultimately developed epiphora, and 12 had masses in the lacrimal sac area. Analysis of preoperative plasma tumor markers indicated 14 patients had elevated homocysteine, 9 had elevated β2-microglobulin, and 2 had elevated lactate dehydrogenase (LDH); 2 patients had elevations of all three markers, and 1 patient had no elevation of any marker. All patients underwent surgical resection and 12 patients received postoperative chemotherapy. The pathological types were DLBCL (n=8), MALT lymphoma (n=5), and NK/T-cell lymphoma, nasal type (n=2). The mean follow-up time was 25.8mo (range: 4-41) and 2 patients died. Seven patients who underwent mass excision combined with dacryocystorhinostomy (DCR) had no postoperative epiphora. Eight patients who only underwent mass excision had varying degrees of postoperative epiphora. Preoperative LDH elevation and NK/T-cell lymphoma, nasal type were associated with poor prognoses. CONCLUSION: Early diagnosis and treatment can lead to a good prognosis for most patients with primary lacrimal sac lymphoma. Mass resection combined with DCR can reduce the occurrence of post-surgical epiphora. The pathology type and tumor marker status are associated with prognosis.http://ies.ijo.cn/en_publish/2023/4/20230406.pdfprimary lacrimal sac lymphomapathological typetumor markerstreatment and prognosis |
| spellingShingle | Fang Bai Hai Tao Xi-Bin Zhou Fei Wang Peng Wang Li-Hua Wang Hong-Yang Zhang Primary lacrimal sac lymphoma: a case-based retrospective study in a Chinese population International Journal of Ophthalmology primary lacrimal sac lymphoma pathological type tumor markers treatment and prognosis |
| title | Primary lacrimal sac lymphoma: a case-based retrospective study in a Chinese population |
| title_full | Primary lacrimal sac lymphoma: a case-based retrospective study in a Chinese population |
| title_fullStr | Primary lacrimal sac lymphoma: a case-based retrospective study in a Chinese population |
| title_full_unstemmed | Primary lacrimal sac lymphoma: a case-based retrospective study in a Chinese population |
| title_short | Primary lacrimal sac lymphoma: a case-based retrospective study in a Chinese population |
| title_sort | primary lacrimal sac lymphoma a case based retrospective study in a chinese population |
| topic | primary lacrimal sac lymphoma pathological type tumor markers treatment and prognosis |
| url | http://ies.ijo.cn/en_publish/2023/4/20230406.pdf |
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