Hypercalcemia, an Important Puzzle Piece in Uncommon Onset Pediatric Sarcoidosis—A Case Report and a Review of the Literature
Sarcoidosis (SD) is a systemic granulomatous condition that is especially encountered in young adults and rarely in children, affecting predominantly the lungs and lymph nodes. We report the case of a 14-year-old teenage boy admitted to our clinic for nausea, vomiting, and weight loss. Clinical exam...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fped.2020.00497/full |
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| author | Cristina Oana Mărginean Lorena Elena Meliţ Gabriel Grigorescu Claudiu Puiac Iunius Simu |
| author_facet | Cristina Oana Mărginean Lorena Elena Meliţ Gabriel Grigorescu Claudiu Puiac Iunius Simu |
| author_sort | Cristina Oana Mărginean |
| collection | DOAJ |
| description | Sarcoidosis (SD) is a systemic granulomatous condition that is especially encountered in young adults and rarely in children, affecting predominantly the lungs and lymph nodes. We report the case of a 14-year-old teenage boy admitted to our clinic for nausea, vomiting, and weight loss. Clinical examination at the time of admission revealed malaise, pallor, and abdominal tenderness in the epigastric area at palpation. Laboratory tests revealed an elevated level of hemoglobin, mild thrombocytosis, increased erythrocyte sedimentation rate, and a mild increase in creatinine and urea levels along with hypercalcemia. An abdominal ultrasound revealed a right ectopic kidney, whereas the upper digestive endoscopy showed intense hyperemia and edema of the gastric mucosa. Thoracic computed tomography scan revealed giant hilar and mediastinal lymphadenopathy, along with multiple micronodules within the lung parenchyma and ground-glass aspect. The level of angiotensin-converting enzyme was high, parathormone was normal, and vitamin D level was low. Pathological examination of the bronchial, mediastinal, and lung biopsies established the diagnosis of SD. We administered oral corticosteroids for 2 months with outstandingly favorable outcome and no signs of recurrence 6 months after the cessation of the therapy. |
| first_indexed | 2024-12-16T15:04:54Z |
| format | Article |
| id | doaj.art-a2ffe49e37e6488eb425c4212cfcc260 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-16T15:04:54Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-a2ffe49e37e6488eb425c4212cfcc2602022-12-21T22:27:11ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602020-08-01810.3389/fped.2020.00497536173Hypercalcemia, an Important Puzzle Piece in Uncommon Onset Pediatric Sarcoidosis—A Case Report and a Review of the LiteratureCristina Oana Mărginean0Lorena Elena Meliţ1Gabriel Grigorescu2Claudiu Puiac3Iunius Simu4Department of Pediatrics, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Târgu Mureș, RomaniaDepartment of Pediatrics, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Târgu Mureș, RomaniaPneumology Clinic, County Emergency Hospital Târgu Mureș, Târgu Mureș, RomaniaDepartment of Emergency Medicine, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Târgu Mureș, RomaniaDepartment of Radiology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Târgu Mureș, RomaniaSarcoidosis (SD) is a systemic granulomatous condition that is especially encountered in young adults and rarely in children, affecting predominantly the lungs and lymph nodes. We report the case of a 14-year-old teenage boy admitted to our clinic for nausea, vomiting, and weight loss. Clinical examination at the time of admission revealed malaise, pallor, and abdominal tenderness in the epigastric area at palpation. Laboratory tests revealed an elevated level of hemoglobin, mild thrombocytosis, increased erythrocyte sedimentation rate, and a mild increase in creatinine and urea levels along with hypercalcemia. An abdominal ultrasound revealed a right ectopic kidney, whereas the upper digestive endoscopy showed intense hyperemia and edema of the gastric mucosa. Thoracic computed tomography scan revealed giant hilar and mediastinal lymphadenopathy, along with multiple micronodules within the lung parenchyma and ground-glass aspect. The level of angiotensin-converting enzyme was high, parathormone was normal, and vitamin D level was low. Pathological examination of the bronchial, mediastinal, and lung biopsies established the diagnosis of SD. We administered oral corticosteroids for 2 months with outstandingly favorable outcome and no signs of recurrence 6 months after the cessation of the therapy.https://www.frontiersin.org/article/10.3389/fped.2020.00497/fullsarcoidosischildrenhypercalcemiarenal failureuncommon onset |
| spellingShingle | Cristina Oana Mărginean Lorena Elena Meliţ Gabriel Grigorescu Claudiu Puiac Iunius Simu Hypercalcemia, an Important Puzzle Piece in Uncommon Onset Pediatric Sarcoidosis—A Case Report and a Review of the Literature Frontiers in Pediatrics sarcoidosis children hypercalcemia renal failure uncommon onset |
| title | Hypercalcemia, an Important Puzzle Piece in Uncommon Onset Pediatric Sarcoidosis—A Case Report and a Review of the Literature |
| title_full | Hypercalcemia, an Important Puzzle Piece in Uncommon Onset Pediatric Sarcoidosis—A Case Report and a Review of the Literature |
| title_fullStr | Hypercalcemia, an Important Puzzle Piece in Uncommon Onset Pediatric Sarcoidosis—A Case Report and a Review of the Literature |
| title_full_unstemmed | Hypercalcemia, an Important Puzzle Piece in Uncommon Onset Pediatric Sarcoidosis—A Case Report and a Review of the Literature |
| title_short | Hypercalcemia, an Important Puzzle Piece in Uncommon Onset Pediatric Sarcoidosis—A Case Report and a Review of the Literature |
| title_sort | hypercalcemia an important puzzle piece in uncommon onset pediatric sarcoidosis a case report and a review of the literature |
| topic | sarcoidosis children hypercalcemia renal failure uncommon onset |
| url | https://www.frontiersin.org/article/10.3389/fped.2020.00497/full |
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