Low alanine aminotransferase activity gene variant in a Siberian Husky with copper-associated hepatopathy
Abstract Background Alanine aminotransferase (ALT) is commonly used as a marker of hepatocellular injury. Increased serum ALT activity due to hepatocyte injury occurs in copper-associated hepatopathy (CuCH) and other necroinflammatory liver conditions. Blood ALT concentrations are frequently used to...
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | BMC Veterinary Research |
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| Online Access: | https://doi.org/10.1186/s12917-023-03681-6 |
| _version_ | 1797559038365401088 |
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| author | Christine Kim John P. Loftus Heather J. Huson |
| author_facet | Christine Kim John P. Loftus Heather J. Huson |
| author_sort | Christine Kim |
| collection | DOAJ |
| description | Abstract Background Alanine aminotransferase (ALT) is commonly used as a marker of hepatocellular injury. Increased serum ALT activity due to hepatocyte injury occurs in copper-associated hepatopathy (CuCH) and other necroinflammatory liver conditions. Blood ALT concentrations are frequently used to monitor therapy in cases of CuCH. Low serum ALT activities have been associated with an allele at a CFA13 locus. Case presentation A 9-year-old female spayed Siberian Husky was diagnosed with CuCH (hepatic copper dry weight 2680 µg/g [normal, 120–400 µg/g; toxic, > 1500 µg/g]) and a normal ALT (78 U/L; reference range, 10–125 U/L). Mild hepatocellular necrosis was evident histologically. Genetic testing (Embark) revealed that the dog was heterozygous for the low ALT activity gene allele. Conclusions This case report illustrates the clinical implications for diagnosing and managing necroinflammatory liver disease such as CuCH in dogs with a low ALT activity genotype. |
| first_indexed | 2024-03-10T17:40:04Z |
| format | Article |
| id | doaj.art-a302d655b8f844f58c6864ab4e7d207f |
| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-03-10T17:40:04Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj.art-a302d655b8f844f58c6864ab4e7d207f2023-11-20T09:44:56ZengBMCBMC Veterinary Research1746-61482023-08-011911510.1186/s12917-023-03681-6Low alanine aminotransferase activity gene variant in a Siberian Husky with copper-associated hepatopathyChristine Kim0John P. Loftus1Heather J. Huson2IronHorse VetCareDepartment of Clinical Sciences, Cornell University College of Veterinary MedicineDepartment of Animal Sciences, Cornell University College of Agriculture and Life SciencesAbstract Background Alanine aminotransferase (ALT) is commonly used as a marker of hepatocellular injury. Increased serum ALT activity due to hepatocyte injury occurs in copper-associated hepatopathy (CuCH) and other necroinflammatory liver conditions. Blood ALT concentrations are frequently used to monitor therapy in cases of CuCH. Low serum ALT activities have been associated with an allele at a CFA13 locus. Case presentation A 9-year-old female spayed Siberian Husky was diagnosed with CuCH (hepatic copper dry weight 2680 µg/g [normal, 120–400 µg/g; toxic, > 1500 µg/g]) and a normal ALT (78 U/L; reference range, 10–125 U/L). Mild hepatocellular necrosis was evident histologically. Genetic testing (Embark) revealed that the dog was heterozygous for the low ALT activity gene allele. Conclusions This case report illustrates the clinical implications for diagnosing and managing necroinflammatory liver disease such as CuCH in dogs with a low ALT activity genotype.https://doi.org/10.1186/s12917-023-03681-6Copper-associated hepatopathyAlanine aminotransferaseChronic hepatopathyCanineGenetics |
| spellingShingle | Christine Kim John P. Loftus Heather J. Huson Low alanine aminotransferase activity gene variant in a Siberian Husky with copper-associated hepatopathy BMC Veterinary Research Copper-associated hepatopathy Alanine aminotransferase Chronic hepatopathy Canine Genetics |
| title | Low alanine aminotransferase activity gene variant in a Siberian Husky with copper-associated hepatopathy |
| title_full | Low alanine aminotransferase activity gene variant in a Siberian Husky with copper-associated hepatopathy |
| title_fullStr | Low alanine aminotransferase activity gene variant in a Siberian Husky with copper-associated hepatopathy |
| title_full_unstemmed | Low alanine aminotransferase activity gene variant in a Siberian Husky with copper-associated hepatopathy |
| title_short | Low alanine aminotransferase activity gene variant in a Siberian Husky with copper-associated hepatopathy |
| title_sort | low alanine aminotransferase activity gene variant in a siberian husky with copper associated hepatopathy |
| topic | Copper-associated hepatopathy Alanine aminotransferase Chronic hepatopathy Canine Genetics |
| url | https://doi.org/10.1186/s12917-023-03681-6 |
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