A university-clustered tuberculosis outbreak during the COVID-19 pandemic in eastern China
During the COVID-19 pandemic in 2020, a tuberculosis outbreak occurred in a university in eastern China, with 4,488 students and 421 staff on the campus. A 19-year-old student was diagnosed in August 2019. Later, the first round of screening was initiated among close contacts, but no active cases we...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.978159/full |
| _version_ | 1828321655031595008 |
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| author | Jizhou Wu Limei Zhu Jiaxi Yu Qiao Liu Xiaoyan Ding Peng Lu Yunliang Wu Jiansheng Sun Leonardo Martinez Wei Lu Jianming Wang Jianming Wang |
| author_facet | Jizhou Wu Limei Zhu Jiaxi Yu Qiao Liu Xiaoyan Ding Peng Lu Yunliang Wu Jiansheng Sun Leonardo Martinez Wei Lu Jianming Wang Jianming Wang |
| author_sort | Jizhou Wu |
| collection | DOAJ |
| description | During the COVID-19 pandemic in 2020, a tuberculosis outbreak occurred in a university in eastern China, with 4,488 students and 421 staff on the campus. A 19-year-old student was diagnosed in August 2019. Later, the first round of screening was initiated among close contacts, but no active cases were found. Till September 2020, four rounds of screening were performed. Four rounds of screening were conducted on September 9, November 8, November 22-25 in 2019 and September 2020, with 0, 5, 0 and 43 cases identified, respectively. A total of 66 active tuberculosis were found in the same university, including 4 sputum culture-positive and 7 sputum smear-positive. The total attack rate of active tuberculosis was 1.34% (66/4909). The whole-genome sequencing showed that the isolates belonged to the same L2 sub-specie and were sensitive to all tested antituberculosis drugs. Delay detection, diagnosis and report of cases were the major cause of this university tuberculosis epidemic. More attention should be paid to the asymptomatic students in the index class. After the occurrence of tuberculosis cases in schools, multiple rounds of screening should be carried out, and preventive therapy should be applied in a timely manner. |
| first_indexed | 2024-04-13T18:29:44Z |
| format | Article |
| id | doaj.art-a302eb1728b34c5199fc12a0024006a4 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-13T18:29:44Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-a302eb1728b34c5199fc12a0024006a42022-12-22T02:35:09ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-08-011010.3389/fpubh.2022.978159978159A university-clustered tuberculosis outbreak during the COVID-19 pandemic in eastern ChinaJizhou Wu0Limei Zhu1Jiaxi Yu2Qiao Liu3Xiaoyan Ding4Peng Lu5Yunliang Wu6Jiansheng Sun7Leonardo Martinez8Wei Lu9Jianming Wang10Jianming Wang11Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, ChinaDepartment of Chronic Communicable Disease, Center for Disease Control and Prevention of Jiangsu Province, Nanjing, ChinaCenter for Disease Control and Prevention of Xuzhou City, Xuzhou, ChinaDepartment of Chronic Communicable Disease, Center for Disease Control and Prevention of Jiangsu Province, Nanjing, ChinaDepartment of Chronic Communicable Disease, Center for Disease Control and Prevention of Jiangsu Province, Nanjing, ChinaDepartment of Chronic Communicable Disease, Center for Disease Control and Prevention of Jiangsu Province, Nanjing, ChinaCenter for Disease Control and Prevention of Xuzhou City, Xuzhou, ChinaCenter for Disease Control and Prevention of Xuzhou City, Xuzhou, ChinaDepartment of Epidemiology, School of Public Health, Boston University, Boston, MA, United StatesDepartment of Chronic Communicable Disease, Center for Disease Control and Prevention of Jiangsu Province, Nanjing, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, ChinaDepartment of Epidemiology, Gusu School, Nanjing Medical University, Nanjing, ChinaDuring the COVID-19 pandemic in 2020, a tuberculosis outbreak occurred in a university in eastern China, with 4,488 students and 421 staff on the campus. A 19-year-old student was diagnosed in August 2019. Later, the first round of screening was initiated among close contacts, but no active cases were found. Till September 2020, four rounds of screening were performed. Four rounds of screening were conducted on September 9, November 8, November 22-25 in 2019 and September 2020, with 0, 5, 0 and 43 cases identified, respectively. A total of 66 active tuberculosis were found in the same university, including 4 sputum culture-positive and 7 sputum smear-positive. The total attack rate of active tuberculosis was 1.34% (66/4909). The whole-genome sequencing showed that the isolates belonged to the same L2 sub-specie and were sensitive to all tested antituberculosis drugs. Delay detection, diagnosis and report of cases were the major cause of this university tuberculosis epidemic. More attention should be paid to the asymptomatic students in the index class. After the occurrence of tuberculosis cases in schools, multiple rounds of screening should be carried out, and preventive therapy should be applied in a timely manner.https://www.frontiersin.org/articles/10.3389/fpubh.2022.978159/fulltuberculosisscreeningwhole-genome sequencingpreventive therapyuniversity |
| spellingShingle | Jizhou Wu Limei Zhu Jiaxi Yu Qiao Liu Xiaoyan Ding Peng Lu Yunliang Wu Jiansheng Sun Leonardo Martinez Wei Lu Jianming Wang Jianming Wang A university-clustered tuberculosis outbreak during the COVID-19 pandemic in eastern China Frontiers in Public Health tuberculosis screening whole-genome sequencing preventive therapy university |
| title | A university-clustered tuberculosis outbreak during the COVID-19 pandemic in eastern China |
| title_full | A university-clustered tuberculosis outbreak during the COVID-19 pandemic in eastern China |
| title_fullStr | A university-clustered tuberculosis outbreak during the COVID-19 pandemic in eastern China |
| title_full_unstemmed | A university-clustered tuberculosis outbreak during the COVID-19 pandemic in eastern China |
| title_short | A university-clustered tuberculosis outbreak during the COVID-19 pandemic in eastern China |
| title_sort | university clustered tuberculosis outbreak during the covid 19 pandemic in eastern china |
| topic | tuberculosis screening whole-genome sequencing preventive therapy university |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.978159/full |
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