Chronic upregulation of circadian clock protein per1 among OSA patients
Introduction PER1 is a repressor protein involved in regulating circadian rhythm. While obstructive sleep apnea (OSA) is characterized by recurred pauses in breathing caused by the collapse of the upper airways it might be associated with disruption of the circadian clock. Objectives The study a...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2021-04-01
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| Series: | European Psychiatry |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933821014796/type/journal_article |
| _version_ | 1797617293427998720 |
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| author | A. Gabryelska M. Sochal P. Bialasiewicz |
| author_facet | A. Gabryelska M. Sochal P. Bialasiewicz |
| author_sort | A. Gabryelska |
| collection | DOAJ |
| description |
Introduction
PER1 is a repressor protein involved in regulating circadian rhythm. While obstructive sleep apnea (OSA) is characterized by recurred pauses in breathing caused by the collapse of the upper airways it might be associated with disruption of the circadian clock.
Objectives
The study aimed to assess PER1 protein in OSA patients and evaluate its association with PSG parameters.
Methods
The study included 40 individuals, who underwent diagnostic polysomnography (PSG) examination. Based apnea-hypopnea index (AHI) patients were divided into groups: control (AHI<5; n=10) and OSA (AHI5; n=30). All participants had their peripheral blood collected in the evening (9:00-10:00 pm) before and in the morning (6:00-7:00 am) after the PSG. PER1 protein concertation measurements were performed using ELISA. Funding: National Science Centre, Poland-2018/31/N/NZ5/03931.
Results
The control and OSA group were match in sex and age, while differed regarding BMI (p=0.039), desaturation index (p<0.001) and AHI (p<0.001). PER1 protein level was elevated in OSA group compared to control both in the evening (322.384.1vs.208.460.1pg/ml;p<0.001) and morning (314.891.9vs.228.157.3pg/ml;p=0.002). No difference was observed between evening and morning PER1 level (p=0.946). Morning PER1 correlated with AHI (r=0.400; p=0.011), desaturation index (r=0.391;p=0.013), age (r=-0.312;p=0.049) and BMI (r=0.383;p=0.015). In a multiple linear regression model (R2=0.268;p=0.003) morning PER1 protein level was influenced by age (p=0.006) and AHI (p=0.025), while BMI and desaturation index were not significant.
Conclusions
OSA patients might suffer from circadian clock disruption, which is mainly associated with the severity of the disorder and age. Further studies are needed as this dysregulation can result in metabolic and mood disorders often observed in this group of patients.
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| first_indexed | 2024-03-11T07:53:46Z |
| format | Article |
| id | doaj.art-a303e72d3e3a4c43ab35dcb479da0ecb |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:53:46Z |
| publishDate | 2021-04-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-a303e72d3e3a4c43ab35dcb479da0ecb2023-11-17T05:06:17ZengCambridge University PressEuropean Psychiatry0924-93381778-35852021-04-0164S554S55510.1192/j.eurpsy.2021.1479Chronic upregulation of circadian clock protein per1 among OSA patientsA. Gabryelska0M. Sochal1P. Bialasiewicz2Department Of Sleep Medicine And Metabolic Disorders, Medical University of Lodz, Poland, Łódź, PolandDepartment Of Sleep Medicine And Metabolic Disorders, Medical University of Lodz, Poland, Łódź, PolandDepartment Of Sleep Medicine And Metabolic Disorders, Medical University of Lodz, Poland, Łódź, Poland Introduction PER1 is a repressor protein involved in regulating circadian rhythm. While obstructive sleep apnea (OSA) is characterized by recurred pauses in breathing caused by the collapse of the upper airways it might be associated with disruption of the circadian clock. Objectives The study aimed to assess PER1 protein in OSA patients and evaluate its association with PSG parameters. Methods The study included 40 individuals, who underwent diagnostic polysomnography (PSG) examination. Based apnea-hypopnea index (AHI) patients were divided into groups: control (AHI<5; n=10) and OSA (AHI5; n=30). All participants had their peripheral blood collected in the evening (9:00-10:00 pm) before and in the morning (6:00-7:00 am) after the PSG. PER1 protein concertation measurements were performed using ELISA. Funding: National Science Centre, Poland-2018/31/N/NZ5/03931. Results The control and OSA group were match in sex and age, while differed regarding BMI (p=0.039), desaturation index (p<0.001) and AHI (p<0.001). PER1 protein level was elevated in OSA group compared to control both in the evening (322.384.1vs.208.460.1pg/ml;p<0.001) and morning (314.891.9vs.228.157.3pg/ml;p=0.002). No difference was observed between evening and morning PER1 level (p=0.946). Morning PER1 correlated with AHI (r=0.400; p=0.011), desaturation index (r=0.391;p=0.013), age (r=-0.312;p=0.049) and BMI (r=0.383;p=0.015). In a multiple linear regression model (R2=0.268;p=0.003) morning PER1 protein level was influenced by age (p=0.006) and AHI (p=0.025), while BMI and desaturation index were not significant. Conclusions OSA patients might suffer from circadian clock disruption, which is mainly associated with the severity of the disorder and age. Further studies are needed as this dysregulation can result in metabolic and mood disorders often observed in this group of patients. https://www.cambridge.org/core/product/identifier/S0924933821014796/type/journal_articleOSAcircadian clockPER1PSG |
| spellingShingle | A. Gabryelska M. Sochal P. Bialasiewicz Chronic upregulation of circadian clock protein per1 among OSA patients European Psychiatry OSA circadian clock PER1 PSG |
| title | Chronic upregulation of circadian clock protein per1 among OSA patients |
| title_full | Chronic upregulation of circadian clock protein per1 among OSA patients |
| title_fullStr | Chronic upregulation of circadian clock protein per1 among OSA patients |
| title_full_unstemmed | Chronic upregulation of circadian clock protein per1 among OSA patients |
| title_short | Chronic upregulation of circadian clock protein per1 among OSA patients |
| title_sort | chronic upregulation of circadian clock protein per1 among osa patients |
| topic | OSA circadian clock PER1 PSG |
| url | https://www.cambridge.org/core/product/identifier/S0924933821014796/type/journal_article |
| work_keys_str_mv | AT agabryelska chronicupregulationofcircadianclockproteinper1amongosapatients AT msochal chronicupregulationofcircadianclockproteinper1amongosapatients AT pbialasiewicz chronicupregulationofcircadianclockproteinper1amongosapatients |