Targeting non-coding RNA family members with artificial endonuclease XNAzymes
Engineered RNA endonuclease XNAzymes can specifically target individual disease-associated non-coding RNAs (ncRNAs) in vitro with potential as platform technology for precision detection or knockdown of individual microRNAs or longer ncRNAs.
Main Authors: | Maria J. Donde, Adam M. Rochussen, Saksham Kapoor, Alexander I. Taylor |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-09-01
|
Series: | Communications Biology |
Online Access: | https://doi.org/10.1038/s42003-022-03987-5 |
Similar Items
-
XNAzymes targeting the SARS-CoV-2 genome inhibit viral infection
by: Pehuén Pereyra Gerber, et al.
Published: (2022-11-01) -
Creation of targeted inversion mutations in plants using an RNA-guided endonuclease
by: Congsheng Zhang, et al.
Published: (2017-02-01) -
The yeast mating-type switching endonuclease HO is a domesticated member of an unorthodox homing genetic element family
by: Aisling Y Coughlan, et al.
Published: (2020-04-01) -
The widespread IS200/IS605 transposon family encodes diverse programmable RNA-guided endonucleases
by: Altae-Tran, Han, et al.
Published: (2022) -
An unnatural enzyme with endonuclease activity towards small non-coding RNAs
by: Noreen Ahmed, et al.
Published: (2023-06-01)