Distinct Poly(A) nucleases have differential impact on sut-2 dependent tauopathy phenotypes.

Distinct Poly(A) nucleases have differential impact on sut-2 dependent tauopathy phenotypes.

Aging drives pathological accumulation of proteins such as tau, causing neurodegenerative dementia disorders like Alzheimer's disease. Previously we showed loss of function mutations in the gene encoding the poly(A) RNA binding protein SUT-2/MSUT2 suppress tau-mediated neurotoxicity in C. elega...

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Bibliographic Details
Main Authors: Rebecca L. Kow, Timothy J. Strovas, Pamela J. McMillan, Ashley M. Jacobi, Mark A. Behlke, Aleen D. Saxton, Caitlin S. Latimer, C. Dirk Keene, Brian C. Kraemer
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Neurobiology of Disease
Subjects:
Tau
SUTSUT-2
MSUT2
Poly(A) deadenylases
TOE1
Neurofibrillary tangles
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612030423X

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