Astrocyte-derived exosomes enriched with miR-873a-5p inhibit neuroinflammation via microglia phenotype modulation after traumatic brain injury

Astrocyte-derived exosomes enriched with miR-873a-5p inhibit neuroinflammation via microglia phenotype modulation after traumatic brain injury

Abstract Background The interaction between astrocytes and microglia plays a vital role in the damage and repair of brain lesions due to traumatic brain injury (TBI). Recent studies have shown that exosomes act as potent mediators involved in intercellular communication. Methods In the current study...

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Bibliographic Details
Main Authors: Xiaobing Long, Xiaolong Yao, Qian Jiang, Yiping Yang, Xuejun He, Weidong Tian, Kai Zhao, Huaqiu Zhang
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Journal of Neuroinflammation
Subjects:
Exosome
Traumatic brain injury
Microglia
Astrocyte
M1/M2
miR-873a-5p
Online Access:http://link.springer.com/article/10.1186/s12974-020-01761-0

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