Epidemiology and Survival of Patients With Brainstem Gliomas: A Population-Based Study Using the SEER Database
BackgroundBrainstem glioma is a primary glial tumor that arises from the midbrain, pons, and medulla. The objective of this study was to determine the population-based epidemiology, incidence, and outcomes of brainstem gliomas.MethodsThe data pertaining to patients with brainstem gliomas diagnosed b...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.692097/full |
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| author | Huanbing Liu Xiaowei Qin Liyan Zhao Gang Zhao Yubo Wang |
| author_facet | Huanbing Liu Xiaowei Qin Liyan Zhao Gang Zhao Yubo Wang |
| author_sort | Huanbing Liu |
| collection | DOAJ |
| description | BackgroundBrainstem glioma is a primary glial tumor that arises from the midbrain, pons, and medulla. The objective of this study was to determine the population-based epidemiology, incidence, and outcomes of brainstem gliomas.MethodsThe data pertaining to patients with brainstem gliomas diagnosed between 2004 and 2016 were extracted from the SEER database. Descriptive analyses were conducted to evaluate the distribution and tumor-related characteristics of patients with brainstem gliomas. The possible prognostic indicators were analyzed by Kaplan-Meier curves and a Cox proportional hazards model.ResultsThe age-adjusted incidence rate was 0.311 cases per 100,000 person-years between 2004 and 2016. A total of 3387 cases of brainstem gliomas were included in our study. Most of the patients were white and diagnosed at 5-9 years of age. The most common diagnosis confirmed by histological review was ependymoma/anaplastic ependymoma. The median survival time was 24 months. Patients with tumors less than 3 cm in size had a better prognosis. Surgery was effective at improving overall survival. There was no evidence that radiotherapy and chemotherapy improved overall survival.ConclusionBrainstem gliomas can be diagnosed at any age. Ependymoma/anaplastic ependymoma is the most common pathological diagnosis. The prognosis is poor, and timely diagnosis and surgery are effective at improving the prognosis. We suggest that more attention should be given to the treatment of patients with brainstem gliomas. |
| first_indexed | 2024-12-21T15:22:07Z |
| format | Article |
| id | doaj.art-a307444d98ca4d37bef56b9d327cb099 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-21T15:22:07Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-a307444d98ca4d37bef56b9d327cb0992022-12-21T18:59:00ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-06-011110.3389/fonc.2021.692097692097Epidemiology and Survival of Patients With Brainstem Gliomas: A Population-Based Study Using the SEER DatabaseHuanbing Liu0Xiaowei Qin1Liyan Zhao2Gang Zhao3Yubo Wang4Department of Neurosurgery, First Hospital of Jilin University, Changchun, ChinaDepartment of Neurosurgery, First Hospital of Jilin University, Changchun, ChinaDepartment of Clinical Laboratory, Second Hospital of Jilin University, Changchun, ChinaDepartment of Neurosurgery, First Hospital of Jilin University, Changchun, ChinaDepartment of Neurosurgery, First Hospital of Jilin University, Changchun, ChinaBackgroundBrainstem glioma is a primary glial tumor that arises from the midbrain, pons, and medulla. The objective of this study was to determine the population-based epidemiology, incidence, and outcomes of brainstem gliomas.MethodsThe data pertaining to patients with brainstem gliomas diagnosed between 2004 and 2016 were extracted from the SEER database. Descriptive analyses were conducted to evaluate the distribution and tumor-related characteristics of patients with brainstem gliomas. The possible prognostic indicators were analyzed by Kaplan-Meier curves and a Cox proportional hazards model.ResultsThe age-adjusted incidence rate was 0.311 cases per 100,000 person-years between 2004 and 2016. A total of 3387 cases of brainstem gliomas were included in our study. Most of the patients were white and diagnosed at 5-9 years of age. The most common diagnosis confirmed by histological review was ependymoma/anaplastic ependymoma. The median survival time was 24 months. Patients with tumors less than 3 cm in size had a better prognosis. Surgery was effective at improving overall survival. There was no evidence that radiotherapy and chemotherapy improved overall survival.ConclusionBrainstem gliomas can be diagnosed at any age. Ependymoma/anaplastic ependymoma is the most common pathological diagnosis. The prognosis is poor, and timely diagnosis and surgery are effective at improving the prognosis. We suggest that more attention should be given to the treatment of patients with brainstem gliomas.https://www.frontiersin.org/articles/10.3389/fonc.2021.692097/fullbrainstem gliomaepidemiologysurvivalSEER ProgramCNS disease |
| spellingShingle | Huanbing Liu Xiaowei Qin Liyan Zhao Gang Zhao Yubo Wang Epidemiology and Survival of Patients With Brainstem Gliomas: A Population-Based Study Using the SEER Database Frontiers in Oncology brainstem glioma epidemiology survival SEER Program CNS disease |
| title | Epidemiology and Survival of Patients With Brainstem Gliomas: A Population-Based Study Using the SEER Database |
| title_full | Epidemiology and Survival of Patients With Brainstem Gliomas: A Population-Based Study Using the SEER Database |
| title_fullStr | Epidemiology and Survival of Patients With Brainstem Gliomas: A Population-Based Study Using the SEER Database |
| title_full_unstemmed | Epidemiology and Survival of Patients With Brainstem Gliomas: A Population-Based Study Using the SEER Database |
| title_short | Epidemiology and Survival of Patients With Brainstem Gliomas: A Population-Based Study Using the SEER Database |
| title_sort | epidemiology and survival of patients with brainstem gliomas a population based study using the seer database |
| topic | brainstem glioma epidemiology survival SEER Program CNS disease |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.692097/full |
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