The Role of Cardiac Resynchronization Therapy for the Management of Functional Mitral Regurgitation
Valve leaflets and chordae structurally normal characterize functional mitral regurgitation (FMR), which in heart failure (HF) setting results from an imbalance between closing and tethering forces secondary to alterations in the left ventricle (LV) and left atrium geometry. In this context, FMR imp...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/11/15/2407 |
| _version_ | 1797442453594177536 |
|---|---|
| author | Eleonora Russo Giulio Russo Mauro Cassese Maurizio Braccio Massimo Carella Paolo Compagnucci Antonio Dello Russo Michela Casella |
| author_facet | Eleonora Russo Giulio Russo Mauro Cassese Maurizio Braccio Massimo Carella Paolo Compagnucci Antonio Dello Russo Michela Casella |
| author_sort | Eleonora Russo |
| collection | DOAJ |
| description | Valve leaflets and chordae structurally normal characterize functional mitral regurgitation (FMR), which in heart failure (HF) setting results from an imbalance between closing and tethering forces secondary to alterations in the left ventricle (LV) and left atrium geometry. In this context, FMR impacts the quality of life and increases mortality. Despite multiple medical and surgical attempts to treat FMR, to date, there is no univocal treatment for many patients. The pathophysiology of FMR is highly complex and involves several underlying mechanisms. Left ventricle dyssynchrony may contribute to FMR onset and worsening and represents an important target for FMR management. In this article, we discuss the mechanisms of FMR and review the potential therapeutic role of CRT, providing a comprehensive review of the available data coming from clinical studies and trials. |
| first_indexed | 2024-03-09T12:43:03Z |
| format | Article |
| id | doaj.art-a3091a627a044b17886f5adbaf19b174 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T12:43:03Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-a3091a627a044b17886f5adbaf19b1742023-11-30T22:16:25ZengMDPI AGCells2073-44092022-08-011115240710.3390/cells11152407The Role of Cardiac Resynchronization Therapy for the Management of Functional Mitral RegurgitationEleonora Russo0Giulio Russo1Mauro Cassese2Maurizio Braccio3Massimo Carella4Paolo Compagnucci5Antonio Dello Russo6Michela Casella7Department of Cardiovascular Disease, IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, ItalyDepartment of Biomedicine and Prevention, Policlinico Tor Vergata, University of Rome, 00133 Rome, ItalyDepartment of Cardiac Surgery, Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, ItalyDepartment of Cardiac Surgery, Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, ItalyScientific Research Department, IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, ItalyCardiology and Arrhythmology Clinic, University Hospital “Ospedali Riuniti Umberto I-Lancisi-Salesi”, 60126 Ancona, ItalyCardiology and Arrhythmology Clinic, University Hospital “Ospedali Riuniti Umberto I-Lancisi-Salesi”, 60126 Ancona, ItalyCardiology and Arrhythmology Clinic, University Hospital “Ospedali Riuniti Umberto I-Lancisi-Salesi”, 60126 Ancona, ItalyValve leaflets and chordae structurally normal characterize functional mitral regurgitation (FMR), which in heart failure (HF) setting results from an imbalance between closing and tethering forces secondary to alterations in the left ventricle (LV) and left atrium geometry. In this context, FMR impacts the quality of life and increases mortality. Despite multiple medical and surgical attempts to treat FMR, to date, there is no univocal treatment for many patients. The pathophysiology of FMR is highly complex and involves several underlying mechanisms. Left ventricle dyssynchrony may contribute to FMR onset and worsening and represents an important target for FMR management. In this article, we discuss the mechanisms of FMR and review the potential therapeutic role of CRT, providing a comprehensive review of the available data coming from clinical studies and trials.https://www.mdpi.com/2073-4409/11/15/2407cardiac resynchronization therapyfunctional mitral regurgitationdyssynchronyheart failureLV remodeling |
| spellingShingle | Eleonora Russo Giulio Russo Mauro Cassese Maurizio Braccio Massimo Carella Paolo Compagnucci Antonio Dello Russo Michela Casella The Role of Cardiac Resynchronization Therapy for the Management of Functional Mitral Regurgitation Cells cardiac resynchronization therapy functional mitral regurgitation dyssynchrony heart failure LV remodeling |
| title | The Role of Cardiac Resynchronization Therapy for the Management of Functional Mitral Regurgitation |
| title_full | The Role of Cardiac Resynchronization Therapy for the Management of Functional Mitral Regurgitation |
| title_fullStr | The Role of Cardiac Resynchronization Therapy for the Management of Functional Mitral Regurgitation |
| title_full_unstemmed | The Role of Cardiac Resynchronization Therapy for the Management of Functional Mitral Regurgitation |
| title_short | The Role of Cardiac Resynchronization Therapy for the Management of Functional Mitral Regurgitation |
| title_sort | role of cardiac resynchronization therapy for the management of functional mitral regurgitation |
| topic | cardiac resynchronization therapy functional mitral regurgitation dyssynchrony heart failure LV remodeling |
| url | https://www.mdpi.com/2073-4409/11/15/2407 |
| work_keys_str_mv | AT eleonorarusso theroleofcardiacresynchronizationtherapyforthemanagementoffunctionalmitralregurgitation AT giuliorusso theroleofcardiacresynchronizationtherapyforthemanagementoffunctionalmitralregurgitation AT maurocassese theroleofcardiacresynchronizationtherapyforthemanagementoffunctionalmitralregurgitation AT mauriziobraccio theroleofcardiacresynchronizationtherapyforthemanagementoffunctionalmitralregurgitation AT massimocarella theroleofcardiacresynchronizationtherapyforthemanagementoffunctionalmitralregurgitation AT paolocompagnucci theroleofcardiacresynchronizationtherapyforthemanagementoffunctionalmitralregurgitation AT antoniodellorusso theroleofcardiacresynchronizationtherapyforthemanagementoffunctionalmitralregurgitation AT michelacasella theroleofcardiacresynchronizationtherapyforthemanagementoffunctionalmitralregurgitation AT eleonorarusso roleofcardiacresynchronizationtherapyforthemanagementoffunctionalmitralregurgitation AT giuliorusso roleofcardiacresynchronizationtherapyforthemanagementoffunctionalmitralregurgitation AT maurocassese roleofcardiacresynchronizationtherapyforthemanagementoffunctionalmitralregurgitation AT mauriziobraccio roleofcardiacresynchronizationtherapyforthemanagementoffunctionalmitralregurgitation AT massimocarella roleofcardiacresynchronizationtherapyforthemanagementoffunctionalmitralregurgitation AT paolocompagnucci roleofcardiacresynchronizationtherapyforthemanagementoffunctionalmitralregurgitation AT antoniodellorusso roleofcardiacresynchronizationtherapyforthemanagementoffunctionalmitralregurgitation AT michelacasella roleofcardiacresynchronizationtherapyforthemanagementoffunctionalmitralregurgitation |