Effect of testosterone undecanoate on sexual functions, glycaemic parameters, and cardiovascular risk factors in hpogonadal men with type 2 diabetes mellitus
Aims: To study the effect of testosterone undecanoate on sexual functions, glycaemic parameters, and cardiovascular (CV) risk factors in hypogonadal men with type 2 diabetes mellitus (T2DM). Methods: It was an open label, single-arm interventional study where testosterone undecanoate (TU) was used...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
|
| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2022;volume=26;issue=6;spage=565;epage=574;aulast=Gandhi |
| _version_ | 1797775232291831808 |
|---|---|
| author | Ronak Gandhi Padala Ravi Kumar Sudhi R Pattanaik Devadarshini Sahoo |
| author_facet | Ronak Gandhi Padala Ravi Kumar Sudhi R Pattanaik Devadarshini Sahoo |
| author_sort | Ronak Gandhi |
| collection | DOAJ |
| description | Aims: To study the effect of testosterone undecanoate on sexual functions, glycaemic parameters, and cardiovascular (CV) risk factors in hypogonadal men with type 2 diabetes mellitus (T2DM). Methods: It was an open label, single-arm interventional study where testosterone undecanoate (TU) was used in 105 T2DM males aged 30–60 years with hypogonadism. The effect of TU on sexual functions was assessed using the Aging Male Symptoms (AMS) Scale and the International Index of Erectile Function-5 (IIEF-5) Questionnaire. The effect on glycaemic parameters, cardiovascular risk factors (lipids, high-sensitivity C-reactive protein [hsCRP] and carotid intima media thickness [CIMT]) were assessed over a period of 54 weeks of TU therapy. Results: Prevalence of hypogonadism in T2DM patients was 19.1%, of which 74.1% had functional hypogonadism. AMS and IIEF-5 scores showed negative and positive correlation, respectively, with baseline serum testosterone levels. The AMS score showed a significant reduction of 5.8% and IIEF-5 score improved by 31.5% at 54 weeks of TU therapy. Glycosylated hemoglobin (HbA1c), homeostatic model assessment for insulin resistance (HOMA-IR), and lipids such as total cholesterol (TC), low-density lipoprotein (LDL), and triglycerides (TG) were significantly reduced by 0.6%, 10.9%, 6.28%, 9.04%, and 6.77%, respectively, at 54 weeks. CIMT was significantly reduced by 2.57% at 54 weeks, whereas no significant change observed with hsCRP. Conclusions: TU is an effective treatment modality for hypogonadal men with T2DM, and it has beneficial effects on sexual functions, glycaemic parameters, and CV risk factors. |
| first_indexed | 2024-03-12T22:31:51Z |
| format | Article |
| id | doaj.art-a309c869a4c941b8a7468713f92e1b76 |
| institution | Directory Open Access Journal |
| issn | 2230-8210 |
| language | English |
| last_indexed | 2024-03-12T22:31:51Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-a309c869a4c941b8a7468713f92e1b762023-07-21T14:56:04ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102022-01-0126656557410.4103/ijem.ijem_39_22Effect of testosterone undecanoate on sexual functions, glycaemic parameters, and cardiovascular risk factors in hpogonadal men with type 2 diabetes mellitusRonak GandhiPadala Ravi KumarSudhi R PattanaikDevadarshini SahooAims: To study the effect of testosterone undecanoate on sexual functions, glycaemic parameters, and cardiovascular (CV) risk factors in hypogonadal men with type 2 diabetes mellitus (T2DM). Methods: It was an open label, single-arm interventional study where testosterone undecanoate (TU) was used in 105 T2DM males aged 30–60 years with hypogonadism. The effect of TU on sexual functions was assessed using the Aging Male Symptoms (AMS) Scale and the International Index of Erectile Function-5 (IIEF-5) Questionnaire. The effect on glycaemic parameters, cardiovascular risk factors (lipids, high-sensitivity C-reactive protein [hsCRP] and carotid intima media thickness [CIMT]) were assessed over a period of 54 weeks of TU therapy. Results: Prevalence of hypogonadism in T2DM patients was 19.1%, of which 74.1% had functional hypogonadism. AMS and IIEF-5 scores showed negative and positive correlation, respectively, with baseline serum testosterone levels. The AMS score showed a significant reduction of 5.8% and IIEF-5 score improved by 31.5% at 54 weeks of TU therapy. Glycosylated hemoglobin (HbA1c), homeostatic model assessment for insulin resistance (HOMA-IR), and lipids such as total cholesterol (TC), low-density lipoprotein (LDL), and triglycerides (TG) were significantly reduced by 0.6%, 10.9%, 6.28%, 9.04%, and 6.77%, respectively, at 54 weeks. CIMT was significantly reduced by 2.57% at 54 weeks, whereas no significant change observed with hsCRP. Conclusions: TU is an effective treatment modality for hypogonadal men with T2DM, and it has beneficial effects on sexual functions, glycaemic parameters, and CV risk factors.http://www.ijem.in/article.asp?issn=2230-8210;year=2022;volume=26;issue=6;spage=565;epage=574;aulast=Gandhiamshoma-irhypogonadismiief-5t2dmtestosterone replacement therapytestosterone undecanoate |
| spellingShingle | Ronak Gandhi Padala Ravi Kumar Sudhi R Pattanaik Devadarshini Sahoo Effect of testosterone undecanoate on sexual functions, glycaemic parameters, and cardiovascular risk factors in hpogonadal men with type 2 diabetes mellitus Indian Journal of Endocrinology and Metabolism ams homa-ir hypogonadism iief-5 t2dm testosterone replacement therapy testosterone undecanoate |
| title | Effect of testosterone undecanoate on sexual functions, glycaemic parameters, and cardiovascular risk factors in hpogonadal men with type 2 diabetes mellitus |
| title_full | Effect of testosterone undecanoate on sexual functions, glycaemic parameters, and cardiovascular risk factors in hpogonadal men with type 2 diabetes mellitus |
| title_fullStr | Effect of testosterone undecanoate on sexual functions, glycaemic parameters, and cardiovascular risk factors in hpogonadal men with type 2 diabetes mellitus |
| title_full_unstemmed | Effect of testosterone undecanoate on sexual functions, glycaemic parameters, and cardiovascular risk factors in hpogonadal men with type 2 diabetes mellitus |
| title_short | Effect of testosterone undecanoate on sexual functions, glycaemic parameters, and cardiovascular risk factors in hpogonadal men with type 2 diabetes mellitus |
| title_sort | effect of testosterone undecanoate on sexual functions glycaemic parameters and cardiovascular risk factors in hpogonadal men with type 2 diabetes mellitus |
| topic | ams homa-ir hypogonadism iief-5 t2dm testosterone replacement therapy testosterone undecanoate |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2022;volume=26;issue=6;spage=565;epage=574;aulast=Gandhi |
| work_keys_str_mv | AT ronakgandhi effectoftestosteroneundecanoateonsexualfunctionsglycaemicparametersandcardiovascularriskfactorsinhpogonadalmenwithtype2diabetesmellitus AT padalaravikumar effectoftestosteroneundecanoateonsexualfunctionsglycaemicparametersandcardiovascularriskfactorsinhpogonadalmenwithtype2diabetesmellitus AT sudhirpattanaik effectoftestosteroneundecanoateonsexualfunctionsglycaemicparametersandcardiovascularriskfactorsinhpogonadalmenwithtype2diabetesmellitus AT devadarshinisahoo effectoftestosteroneundecanoateonsexualfunctionsglycaemicparametersandcardiovascularriskfactorsinhpogonadalmenwithtype2diabetesmellitus |