An uncommon cause of rapidly progressive renal failure in a lupus patient: Pauci-immune crescentic glomerulonephritis
We report a case of systemic lupus erythematosus (SLE) who presented with rapidly progressive renal failure (RPRF) with positive antinuclear antibody (ANA) and anti-double-stranded DNA (dsDNA) antibody and active urinary sediment in the form of microscopic hematuria and proteinuria. Provisional clin...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Saudi Journal of Kidney Diseases and Transplantation |
| Online Access: | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2018;volume=29;issue=4;spage=989;epage=992;aulast=Balwani |
| _version_ | 1818128888160583680 |
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| author | Manish R Balwani Charulata Bawankule Prakash Khetan Vishal Ramteke Priyanka Tolani Vivek Kute |
| author_facet | Manish R Balwani Charulata Bawankule Prakash Khetan Vishal Ramteke Priyanka Tolani Vivek Kute |
| author_sort | Manish R Balwani |
| collection | DOAJ |
| description | We report a case of systemic lupus erythematosus (SLE) who presented with rapidly progressive renal failure (RPRF) with positive antinuclear antibody (ANA) and anti-double-stranded DNA (dsDNA) antibody and active urinary sediment in the form of microscopic hematuria and proteinuria. Provisional clinical diagnosis of lupus nephritis was made. Renal biopsy showed pauci-immune crescentic glomerulonephritis, the diagnosis of which was supported by positive serum anti-MPO antibody. Renal biopsy in SLE patients can sometimes reveal varied pathological entities such as antinuclear cytoplasmic antibodies (ANCAs) positive vasculitis, as in our case, which modified our treatment protocol. Thus, in a patient with SLE presenting with RPRF with active urinary sediments, ANCA serology, and renal biopsy with immunofluorescence examination should be performed always. |
| first_indexed | 2024-12-11T07:40:24Z |
| format | Article |
| id | doaj.art-a30b95a35a8742ef8111e543e44db17d |
| institution | Directory Open Access Journal |
| issn | 1319-2442 |
| language | English |
| last_indexed | 2024-12-11T07:40:24Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Kidney Diseases and Transplantation |
| spelling | doaj.art-a30b95a35a8742ef8111e543e44db17d2022-12-22T01:15:35ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422018-01-0129498999210.4103/1319-2442.239632An uncommon cause of rapidly progressive renal failure in a lupus patient: Pauci-immune crescentic glomerulonephritisManish R BalwaniCharulata BawankulePrakash KhetanVishal RamtekePriyanka TolaniVivek KuteWe report a case of systemic lupus erythematosus (SLE) who presented with rapidly progressive renal failure (RPRF) with positive antinuclear antibody (ANA) and anti-double-stranded DNA (dsDNA) antibody and active urinary sediment in the form of microscopic hematuria and proteinuria. Provisional clinical diagnosis of lupus nephritis was made. Renal biopsy showed pauci-immune crescentic glomerulonephritis, the diagnosis of which was supported by positive serum anti-MPO antibody. Renal biopsy in SLE patients can sometimes reveal varied pathological entities such as antinuclear cytoplasmic antibodies (ANCAs) positive vasculitis, as in our case, which modified our treatment protocol. Thus, in a patient with SLE presenting with RPRF with active urinary sediments, ANCA serology, and renal biopsy with immunofluorescence examination should be performed always.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2018;volume=29;issue=4;spage=989;epage=992;aulast=Balwani |
| spellingShingle | Manish R Balwani Charulata Bawankule Prakash Khetan Vishal Ramteke Priyanka Tolani Vivek Kute An uncommon cause of rapidly progressive renal failure in a lupus patient: Pauci-immune crescentic glomerulonephritis Saudi Journal of Kidney Diseases and Transplantation |
| title | An uncommon cause of rapidly progressive renal failure in a lupus patient: Pauci-immune crescentic glomerulonephritis |
| title_full | An uncommon cause of rapidly progressive renal failure in a lupus patient: Pauci-immune crescentic glomerulonephritis |
| title_fullStr | An uncommon cause of rapidly progressive renal failure in a lupus patient: Pauci-immune crescentic glomerulonephritis |
| title_full_unstemmed | An uncommon cause of rapidly progressive renal failure in a lupus patient: Pauci-immune crescentic glomerulonephritis |
| title_short | An uncommon cause of rapidly progressive renal failure in a lupus patient: Pauci-immune crescentic glomerulonephritis |
| title_sort | uncommon cause of rapidly progressive renal failure in a lupus patient pauci immune crescentic glomerulonephritis |
| url | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2018;volume=29;issue=4;spage=989;epage=992;aulast=Balwani |
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