Significance of the viral load of high-risk HPV in the diagnosis and prediction of cervical lesions: a retrospective study
Abstract Background The significance of HPV viral load in the detection of cervical lesions is still controversial. This study analyzed the correlation between the high-risk HPV viral load and different cervical lesion degrees. Methods This retrospective study included women positive for high-risk H...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-10-01
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| Series: | BMC Women's Health |
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| Online Access: | https://doi.org/10.1186/s12905-021-01493-0 |
| _version_ | 1818986299035484160 |
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| author | Yang Liu Changjun Xu Jing Pan Chunyi Sun Honglin Zhou Yushi Meng |
| author_facet | Yang Liu Changjun Xu Jing Pan Chunyi Sun Honglin Zhou Yushi Meng |
| author_sort | Yang Liu |
| collection | DOAJ |
| description | Abstract Background The significance of HPV viral load in the detection of cervical lesions is still controversial. This study analyzed the correlation between the high-risk HPV viral load and different cervical lesion degrees. Methods This retrospective study included women positive for high-risk HPV DNA and screened for cervical lesions between 01/2015 and 06/2018. The high-risk HPV DNA load was measured by the second-generation Hybrid Capture technology and classified as low, moderate, and high. Colposcopy and biopsy were performed in all patients. The patients were grouped as normal, cervical intraepithelial neoplasia (CIN) grade 1, CIN grade 2, CIN grade 3, and cervical cancer. Multivariable logistic regression was performed to explore the association between high-risk HPV DNA load and cervical lesions. The odds ratios (ORs) represent the odds for increasing from low to high viral load. Results Finally, 265 patients were grouped as normal (n = 125), CIN 1 (n = 51), CIN 2 (n = 23), CIN 3 (n = 46), and cervical cancer (n = 20). Among them, 139 (52.5%) had a low viral load, 90 (34.0) had a moderate viral load, and 36 (13.4%) had a high viral load. Taking the normal control group as a reference, a high viral load was an independent factor for CIN 1 (OR = 3.568, 95% CI: 1.164–10.941, P = 0.026), CIN 2 (OR = 6.939, 95% CI: 1.793–26.852, P = 0.005), CIN 3 (OR = 7.052, 95% CI: 2.304–21.586, P = 0.001), and cervical cancer (OR = 8.266, 95% CI: 2.120–32.233, P = 0.002). Conclusions Among women who underwent cervical biopsy, higher high-risk HPV viral load in cervical lesions was associated with a higher risk of high-grade cervical lesions. |
| first_indexed | 2024-12-20T18:48:35Z |
| format | Article |
| id | doaj.art-a30c699e9afb48759177d49a7e040d0f |
| institution | Directory Open Access Journal |
| issn | 1472-6874 |
| language | English |
| last_indexed | 2024-12-20T18:48:35Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Women's Health |
| spelling | doaj.art-a30c699e9afb48759177d49a7e040d0f2022-12-21T19:29:38ZengBMCBMC Women's Health1472-68742021-10-012111610.1186/s12905-021-01493-0Significance of the viral load of high-risk HPV in the diagnosis and prediction of cervical lesions: a retrospective studyYang Liu0Changjun Xu1Jing Pan2Chunyi Sun3Honglin Zhou4Yushi Meng5Department of Reproduction, The Second Affiliated Hospital of Kunming Medical UniversityDepartment of Reproductive Medicine, People’s Hospital of Yuxi CityDepartment of Gynecology, The Second Affiliated Hospital of Kunming Medical UniversityDepartment of Gynecology, The Second Affiliated Hospital of Kunming Medical UniversityDepartment of Gynecology, The Second Affiliated Hospital of Kunming Medical UniversityDepartment of Reproduction, The Second Affiliated Hospital of Kunming Medical UniversityAbstract Background The significance of HPV viral load in the detection of cervical lesions is still controversial. This study analyzed the correlation between the high-risk HPV viral load and different cervical lesion degrees. Methods This retrospective study included women positive for high-risk HPV DNA and screened for cervical lesions between 01/2015 and 06/2018. The high-risk HPV DNA load was measured by the second-generation Hybrid Capture technology and classified as low, moderate, and high. Colposcopy and biopsy were performed in all patients. The patients were grouped as normal, cervical intraepithelial neoplasia (CIN) grade 1, CIN grade 2, CIN grade 3, and cervical cancer. Multivariable logistic regression was performed to explore the association between high-risk HPV DNA load and cervical lesions. The odds ratios (ORs) represent the odds for increasing from low to high viral load. Results Finally, 265 patients were grouped as normal (n = 125), CIN 1 (n = 51), CIN 2 (n = 23), CIN 3 (n = 46), and cervical cancer (n = 20). Among them, 139 (52.5%) had a low viral load, 90 (34.0) had a moderate viral load, and 36 (13.4%) had a high viral load. Taking the normal control group as a reference, a high viral load was an independent factor for CIN 1 (OR = 3.568, 95% CI: 1.164–10.941, P = 0.026), CIN 2 (OR = 6.939, 95% CI: 1.793–26.852, P = 0.005), CIN 3 (OR = 7.052, 95% CI: 2.304–21.586, P = 0.001), and cervical cancer (OR = 8.266, 95% CI: 2.120–32.233, P = 0.002). Conclusions Among women who underwent cervical biopsy, higher high-risk HPV viral load in cervical lesions was associated with a higher risk of high-grade cervical lesions.https://doi.org/10.1186/s12905-021-01493-0Cervical cancerCervical intraepithelial neoplasiaHuman papillomavirusViral loadPredictive value |
| spellingShingle | Yang Liu Changjun Xu Jing Pan Chunyi Sun Honglin Zhou Yushi Meng Significance of the viral load of high-risk HPV in the diagnosis and prediction of cervical lesions: a retrospective study BMC Women's Health Cervical cancer Cervical intraepithelial neoplasia Human papillomavirus Viral load Predictive value |
| title | Significance of the viral load of high-risk HPV in the diagnosis and prediction of cervical lesions: a retrospective study |
| title_full | Significance of the viral load of high-risk HPV in the diagnosis and prediction of cervical lesions: a retrospective study |
| title_fullStr | Significance of the viral load of high-risk HPV in the diagnosis and prediction of cervical lesions: a retrospective study |
| title_full_unstemmed | Significance of the viral load of high-risk HPV in the diagnosis and prediction of cervical lesions: a retrospective study |
| title_short | Significance of the viral load of high-risk HPV in the diagnosis and prediction of cervical lesions: a retrospective study |
| title_sort | significance of the viral load of high risk hpv in the diagnosis and prediction of cervical lesions a retrospective study |
| topic | Cervical cancer Cervical intraepithelial neoplasia Human papillomavirus Viral load Predictive value |
| url | https://doi.org/10.1186/s12905-021-01493-0 |
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