Spotlight on landmark oncology trials: the latest evidence and novel trial designs
Abstract The era of precision oncology is marked with prominent successes in the therapy of advanced soft tissue sarcomas, breast cancer, ovarian cancer and haematological neoplasms, among others. Moreover, recent trials of immune checkpoint inhibitors in melanoma, non-small cell lung carcinoma, and...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-06-01
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| Series: | BMC Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s12916-017-0884-7 |
| _version_ | 1818509627144273920 |
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| author | Helena Earl Stefano Molica Piotr Rutkowski |
| author_facet | Helena Earl Stefano Molica Piotr Rutkowski |
| author_sort | Helena Earl |
| collection | DOAJ |
| description | Abstract The era of precision oncology is marked with prominent successes in the therapy of advanced soft tissue sarcomas, breast cancer, ovarian cancer and haematological neoplasms, among others. Moreover, recent trials of immune checkpoint inhibitors in melanoma, non-small cell lung carcinoma, and head and neck cancers have significantly influenced the therapeutic landscape by providing promising evidence for immunotherapy efficacy in the adjuvant setting in high-risk locoregional disease. To speed up the introduction of targeted therapy for cancer patients, novel phase II trials are being designed, and may likely form the basis for the ‘landmark trials’ of the future. A special article collection in BMC Medicine, “Spotlight on landmark oncology trials”, features articles from invited experts on recent clinical practice-changing trials. |
| first_indexed | 2024-12-10T22:47:59Z |
| format | Article |
| id | doaj.art-a30cd8333b6740c29f560d2221cb6691 |
| institution | Directory Open Access Journal |
| issn | 1741-7015 |
| language | English |
| last_indexed | 2024-12-10T22:47:59Z |
| publishDate | 2017-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj.art-a30cd8333b6740c29f560d2221cb66912022-12-22T01:30:31ZengBMCBMC Medicine1741-70152017-06-011511610.1186/s12916-017-0884-7Spotlight on landmark oncology trials: the latest evidence and novel trial designsHelena Earl0Stefano Molica1Piotr Rutkowski2University of Cambridge Department of Oncology, NIHR Cambridge Biomedical Research Centre, and Hon Consultant in Medical Oncology, Cambridge University Hospital NHS Foundation TrustDepartment Hematology-Oncology, Azienda Ospedaliera Pugliese-CiaccioDepartment of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Institute - Oncology CenterAbstract The era of precision oncology is marked with prominent successes in the therapy of advanced soft tissue sarcomas, breast cancer, ovarian cancer and haematological neoplasms, among others. Moreover, recent trials of immune checkpoint inhibitors in melanoma, non-small cell lung carcinoma, and head and neck cancers have significantly influenced the therapeutic landscape by providing promising evidence for immunotherapy efficacy in the adjuvant setting in high-risk locoregional disease. To speed up the introduction of targeted therapy for cancer patients, novel phase II trials are being designed, and may likely form the basis for the ‘landmark trials’ of the future. A special article collection in BMC Medicine, “Spotlight on landmark oncology trials”, features articles from invited experts on recent clinical practice-changing trials.http://link.springer.com/article/10.1186/s12916-017-0884-7CancerClinical trialsOncologyRandomised trialsTargeted therapyTrial design |
| spellingShingle | Helena Earl Stefano Molica Piotr Rutkowski Spotlight on landmark oncology trials: the latest evidence and novel trial designs BMC Medicine Cancer Clinical trials Oncology Randomised trials Targeted therapy Trial design |
| title | Spotlight on landmark oncology trials: the latest evidence and novel trial designs |
| title_full | Spotlight on landmark oncology trials: the latest evidence and novel trial designs |
| title_fullStr | Spotlight on landmark oncology trials: the latest evidence and novel trial designs |
| title_full_unstemmed | Spotlight on landmark oncology trials: the latest evidence and novel trial designs |
| title_short | Spotlight on landmark oncology trials: the latest evidence and novel trial designs |
| title_sort | spotlight on landmark oncology trials the latest evidence and novel trial designs |
| topic | Cancer Clinical trials Oncology Randomised trials Targeted therapy Trial design |
| url | http://link.springer.com/article/10.1186/s12916-017-0884-7 |
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