Drug repurposing: re-inventing therapies for cancer without re-entering the development pipeline—a review
Abstract While majority of the current treatment approaches for cancer remain expensive and are associated with several side effects, development of new treatment modalities takes a significant period of research, time, and expenditure. An alternative novel approach is drug repurposing that focuses...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-08-01
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| Series: | Journal of the Egyptian National Cancer Institute |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43046-022-00137-0 |
| _version_ | 1811320779343659008 |
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| author | Shafina Siddiqui Ankita Jaywant Deshmukh Priyanka Mudaliar Apoorva Jagannath Nalawade Deepak Iyer Jyotirmoi Aich |
| author_facet | Shafina Siddiqui Ankita Jaywant Deshmukh Priyanka Mudaliar Apoorva Jagannath Nalawade Deepak Iyer Jyotirmoi Aich |
| author_sort | Shafina Siddiqui |
| collection | DOAJ |
| description | Abstract While majority of the current treatment approaches for cancer remain expensive and are associated with several side effects, development of new treatment modalities takes a significant period of research, time, and expenditure. An alternative novel approach is drug repurposing that focuses on finding new applications for the previously clinically approved drugs. The process of drug repurposing has also been facilitated by current advances in the field of proteomics, genomics, and information computational biology. This approach not only provides cheaper, effective, and potentially safer drugs with less side effects but also increases the processing pace of drug development. In this review, we wish to highlight some recent developments in the area of drug repurposing in cancer with a specific focus on the repurposing potential of anti-psychotic, anti-inflammatory and anti-viral drugs, anti-diabetic, antibacterial, and anti-fungal drugs. |
| first_indexed | 2024-04-13T13:05:25Z |
| format | Article |
| id | doaj.art-a30de6be82d146f9b3555143f757fed6 |
| institution | Directory Open Access Journal |
| issn | 2589-0409 |
| language | English |
| last_indexed | 2024-04-13T13:05:25Z |
| publishDate | 2022-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of the Egyptian National Cancer Institute |
| spelling | doaj.art-a30de6be82d146f9b3555143f757fed62022-12-22T02:45:47ZengSpringerOpenJournal of the Egyptian National Cancer Institute2589-04092022-08-0134111210.1186/s43046-022-00137-0Drug repurposing: re-inventing therapies for cancer without re-entering the development pipeline—a reviewShafina Siddiqui0Ankita Jaywant Deshmukh1Priyanka Mudaliar2Apoorva Jagannath Nalawade3Deepak Iyer4Jyotirmoi Aich5School of Biotechnology and Bioinformatics, DY Patil Deemed to Be UniversitySchool of Biotechnology and Bioinformatics, DY Patil Deemed to Be UniversitySchool of Biotechnology and Bioinformatics, DY Patil Deemed to Be UniversitySchool of Biotechnology and Bioinformatics, DY Patil Deemed to Be UniversityLaboratory Medicine Program, Toronto General Hospital, University Health Network, University of TorontoSchool of Biotechnology and Bioinformatics, DY Patil Deemed to Be UniversityAbstract While majority of the current treatment approaches for cancer remain expensive and are associated with several side effects, development of new treatment modalities takes a significant period of research, time, and expenditure. An alternative novel approach is drug repurposing that focuses on finding new applications for the previously clinically approved drugs. The process of drug repurposing has also been facilitated by current advances in the field of proteomics, genomics, and information computational biology. This approach not only provides cheaper, effective, and potentially safer drugs with less side effects but also increases the processing pace of drug development. In this review, we wish to highlight some recent developments in the area of drug repurposing in cancer with a specific focus on the repurposing potential of anti-psychotic, anti-inflammatory and anti-viral drugs, anti-diabetic, antibacterial, and anti-fungal drugs.https://doi.org/10.1186/s43046-022-00137-0CancerDrug resistanceDrug repurposingAnti-psychoticAnti-inflammatoryAnti-viral |
| spellingShingle | Shafina Siddiqui Ankita Jaywant Deshmukh Priyanka Mudaliar Apoorva Jagannath Nalawade Deepak Iyer Jyotirmoi Aich Drug repurposing: re-inventing therapies for cancer without re-entering the development pipeline—a review Journal of the Egyptian National Cancer Institute Cancer Drug resistance Drug repurposing Anti-psychotic Anti-inflammatory Anti-viral |
| title | Drug repurposing: re-inventing therapies for cancer without re-entering the development pipeline—a review |
| title_full | Drug repurposing: re-inventing therapies for cancer without re-entering the development pipeline—a review |
| title_fullStr | Drug repurposing: re-inventing therapies for cancer without re-entering the development pipeline—a review |
| title_full_unstemmed | Drug repurposing: re-inventing therapies for cancer without re-entering the development pipeline—a review |
| title_short | Drug repurposing: re-inventing therapies for cancer without re-entering the development pipeline—a review |
| title_sort | drug repurposing re inventing therapies for cancer without re entering the development pipeline a review |
| topic | Cancer Drug resistance Drug repurposing Anti-psychotic Anti-inflammatory Anti-viral |
| url | https://doi.org/10.1186/s43046-022-00137-0 |
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