A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity

A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity

Abstract Memory and long term potentiation require de novo protein synthesis. A key regulator of this process is mTORC1, a complex comprising the mTOR kinase. Growth factors activate mTORC1 via a pathway involving PI3-kinase, Akt, the TSC complex and the GTPase Rheb. In non-neuronal cells, transloca...

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Bibliographic Details
Main Authors: Dany Khamsing, Solène Lebrun, Isabelle Fanget, Nathanaël Larochette, Christophe Tourain, Vincent de Sars, Maia Brunstein, Martin Oheim, Damien Carrel, François Darchen, Claire Desnos
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Molecular Brain
Subjects:
mTOR
Endo-lysosomes
NMDA receptors
BDNF
Synaptic plasticity
Optogenetics
Online Access:https://doi.org/10.1186/s13041-021-00820-8

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