Characterization and impact of non‐canonical WNT signaling on outcomes of urothelial carcinoma

Characterization and impact of non‐canonical WNT signaling on outcomes of urothelial carcinoma

Abstract Background Non‐canonical WNT family (WNT5A pathway) signaling via WNT5A through ROR1 and its partner, ROR2, or Frizzled2 (FZD2) is linked to processes driving tumorigenesis and therapy resistance. We utilized a large dataset of urothelial carcinoma (UC) tumors to characterize non‐canonical...

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Bibliographic Details
Main Authors: Margaret Meagher, Harris Krause, Andrew Elliott, Alex Farrell, Emmanuel S. Antonarakis, Bruno Bastos, Elisabeth I. Heath, Christina Jamieson, Tyler F. Stewart, Aditya Bagrodia, Chadi Nabhan, Matt Oberley, Rana R. McKay, Amirali Salmasi
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Cancer Medicine
Subjects:
FZD2
Non‐canonical
ROR
Urothelial carcinoma
WNT signaling
WNT5A
Online Access:https://doi.org/10.1002/cam4.7148

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