Presynaptic Boutons That Contain Mitochondria Are More Stable
The addition and removal of presynaptic terminals reconfigures neuronal circuits of the mammalian neocortex, but little is known about how this presynaptic structural plasticity is controlled. Since mitochondria can regulate presynaptic function, we investigated whether the presence of axonal mitoch...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-01-01
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| Series: | Frontiers in Synaptic Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnsyn.2019.00037/full |
| _version_ | 1818321712616308736 |
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| author | Robert M. Lees James D. Johnson Michael C. Ashby |
| author_facet | Robert M. Lees James D. Johnson Michael C. Ashby |
| author_sort | Robert M. Lees |
| collection | DOAJ |
| description | The addition and removal of presynaptic terminals reconfigures neuronal circuits of the mammalian neocortex, but little is known about how this presynaptic structural plasticity is controlled. Since mitochondria can regulate presynaptic function, we investigated whether the presence of axonal mitochondria relates to the structural plasticity of presynaptic boutons in mouse neocortex. We found that the overall density of axonal mitochondria did not appear to influence the loss and gain of boutons. However, positioning of mitochondria at individual presynaptic sites did relate to increased stability of those boutons. In line with this, synaptic localization of mitochondria increased as boutons aged and showed differing patterns of localization at en passant and terminaux boutons. These results suggest that mitochondria accumulate locally at boutons over time to increase bouton stability. |
| first_indexed | 2024-12-13T10:45:16Z |
| format | Article |
| id | doaj.art-a30f286128ec4ddeac985377837d4166 |
| institution | Directory Open Access Journal |
| issn | 1663-3563 |
| language | English |
| last_indexed | 2024-12-13T10:45:16Z |
| publishDate | 2020-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Synaptic Neuroscience |
| spelling | doaj.art-a30f286128ec4ddeac985377837d41662022-12-21T23:50:14ZengFrontiers Media S.A.Frontiers in Synaptic Neuroscience1663-35632020-01-011110.3389/fnsyn.2019.00037503315Presynaptic Boutons That Contain Mitochondria Are More StableRobert M. LeesJames D. JohnsonMichael C. AshbyThe addition and removal of presynaptic terminals reconfigures neuronal circuits of the mammalian neocortex, but little is known about how this presynaptic structural plasticity is controlled. Since mitochondria can regulate presynaptic function, we investigated whether the presence of axonal mitochondria relates to the structural plasticity of presynaptic boutons in mouse neocortex. We found that the overall density of axonal mitochondria did not appear to influence the loss and gain of boutons. However, positioning of mitochondria at individual presynaptic sites did relate to increased stability of those boutons. In line with this, synaptic localization of mitochondria increased as boutons aged and showed differing patterns of localization at en passant and terminaux boutons. These results suggest that mitochondria accumulate locally at boutons over time to increase bouton stability.https://www.frontiersin.org/article/10.3389/fnsyn.2019.00037/fullpresynaptic boutonsynaptic plasticityin vivo 2-photon imagingmitochondrianeocortexsynapse turnover |
| spellingShingle | Robert M. Lees James D. Johnson Michael C. Ashby Presynaptic Boutons That Contain Mitochondria Are More Stable Frontiers in Synaptic Neuroscience presynaptic bouton synaptic plasticity in vivo 2-photon imaging mitochondria neocortex synapse turnover |
| title | Presynaptic Boutons That Contain Mitochondria Are More Stable |
| title_full | Presynaptic Boutons That Contain Mitochondria Are More Stable |
| title_fullStr | Presynaptic Boutons That Contain Mitochondria Are More Stable |
| title_full_unstemmed | Presynaptic Boutons That Contain Mitochondria Are More Stable |
| title_short | Presynaptic Boutons That Contain Mitochondria Are More Stable |
| title_sort | presynaptic boutons that contain mitochondria are more stable |
| topic | presynaptic bouton synaptic plasticity in vivo 2-photon imaging mitochondria neocortex synapse turnover |
| url | https://www.frontiersin.org/article/10.3389/fnsyn.2019.00037/full |
| work_keys_str_mv | AT robertmlees presynapticboutonsthatcontainmitochondriaaremorestable AT jamesdjohnson presynapticboutonsthatcontainmitochondriaaremorestable AT michaelcashby presynapticboutonsthatcontainmitochondriaaremorestable |