Metabolic dysfunction: The silenced connection with fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) represents a global public health burden. Despite the increase in its prevalence, the disease has not received sufficient attention compared to the associated diseases such as diabetes mellitus and obesity. In 2020 it was proposed to rename NAFLD to metaboli...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Annals of Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268123002429 |
| _version_ | 1797647636607533056 |
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| author | Mariana M. Ramírez-Mejía Xingshun Qi Ludovico Abenavoli Manuel Romero-Gómez Mohammed Eslam Nahum Méndez-Sánchez |
| author_facet | Mariana M. Ramírez-Mejía Xingshun Qi Ludovico Abenavoli Manuel Romero-Gómez Mohammed Eslam Nahum Méndez-Sánchez |
| author_sort | Mariana M. Ramírez-Mejía |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) represents a global public health burden. Despite the increase in its prevalence, the disease has not received sufficient attention compared to the associated diseases such as diabetes mellitus and obesity. In 2020 it was proposed to rename NAFLD to metabolic dysfunction-associated fatty liver disease (MAFLD) in order to recognize the metabolic risk factors and the complex pathophysiological mechanisms associated with its development. Furthermore, along with the implementation of the proposed diagnostic criteria, the aim is to address the whole clinical spectrum of the disease, regardless of BMI and the presence of other hepatic comorbidities. As would it be expected with such a paradigm shift, differing viewpoints have emerged regarding the benefits and disadvantages of renaming fatty liver disease. The following review aims to describe the way to the MAFLD from a historical, pathophysiological and clinical perspective in order to highlight why MAFLD is the approach to follow. |
| first_indexed | 2024-03-11T15:19:23Z |
| format | Article |
| id | doaj.art-a3116ef3e42444d488c75a7f124b7837 |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-03-11T15:19:23Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-a3116ef3e42444d488c75a7f124b78372023-10-29T04:19:30ZengElsevierAnnals of Hepatology1665-26812023-11-01286101138Metabolic dysfunction: The silenced connection with fatty liver diseaseMariana M. Ramírez-Mejía0Xingshun Qi1Ludovico Abenavoli2Manuel Romero-Gómez3Mohammed Eslam4Nahum Méndez-Sánchez5Plan of Combined Studies in Medicine (PECEM-MD/PhD), Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico; Liver Research Unit, Medica Sur Clinic & Foundation, Mexico City, MexicoDepartment of Gastroenterology, General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), Liaoning Province, ChinaDepartment of Health Sciences, University Magna Graecia of Catanzaro, ItalyDigestive Diseases Unit, Department of Medicine, SeLiver Group, Institute of Biomedicine of Sevilla (HUVR/CSIC/US), University of Seville, Hospital Universitario Virgen del Rocío, Seville, SpainStorr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, NSW, AustraliaLiver Research Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico; Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico; Corresponding author.Non-alcoholic fatty liver disease (NAFLD) represents a global public health burden. Despite the increase in its prevalence, the disease has not received sufficient attention compared to the associated diseases such as diabetes mellitus and obesity. In 2020 it was proposed to rename NAFLD to metabolic dysfunction-associated fatty liver disease (MAFLD) in order to recognize the metabolic risk factors and the complex pathophysiological mechanisms associated with its development. Furthermore, along with the implementation of the proposed diagnostic criteria, the aim is to address the whole clinical spectrum of the disease, regardless of BMI and the presence of other hepatic comorbidities. As would it be expected with such a paradigm shift, differing viewpoints have emerged regarding the benefits and disadvantages of renaming fatty liver disease. The following review aims to describe the way to the MAFLD from a historical, pathophysiological and clinical perspective in order to highlight why MAFLD is the approach to follow.http://www.sciencedirect.com/science/article/pii/S1665268123002429MAFLDNAFLDMetabolic syndromeMetabolic dysfunctionLiverDiabetes |
| spellingShingle | Mariana M. Ramírez-Mejía Xingshun Qi Ludovico Abenavoli Manuel Romero-Gómez Mohammed Eslam Nahum Méndez-Sánchez Metabolic dysfunction: The silenced connection with fatty liver disease Annals of Hepatology MAFLD NAFLD Metabolic syndrome Metabolic dysfunction Liver Diabetes |
| title | Metabolic dysfunction: The silenced connection with fatty liver disease |
| title_full | Metabolic dysfunction: The silenced connection with fatty liver disease |
| title_fullStr | Metabolic dysfunction: The silenced connection with fatty liver disease |
| title_full_unstemmed | Metabolic dysfunction: The silenced connection with fatty liver disease |
| title_short | Metabolic dysfunction: The silenced connection with fatty liver disease |
| title_sort | metabolic dysfunction the silenced connection with fatty liver disease |
| topic | MAFLD NAFLD Metabolic syndrome Metabolic dysfunction Liver Diabetes |
| url | http://www.sciencedirect.com/science/article/pii/S1665268123002429 |
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