Combined Targeting of AKT and mTOR Inhibits Tumor Formation of EpCAM<sup>+</sup> and CD90<sup>+</sup> Human Hepatocellular Carcinoma Cells in an Orthotopic Mouse Model

Combined Targeting of AKT and mTOR Inhibits Tumor Formation of EpCAM<sup>+</sup> and CD90<sup>+</sup> Human Hepatocellular Carcinoma Cells in an Orthotopic Mouse Model

The epithelial cell adhesion molecule (EpCAM) and Thy-1 cell surface antigen (CD90) have been implicated as cancer stem cell (CSC) markers in hepatocellular carcinoma (HCC). Expression of EpCAM and CD90 on HCC cells is associated with increased tumorigenicity, metastasis and poor prognosis. In this...

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Bibliographic Details
Main Authors: Mohamed Moustafa, Katarzyna-Krystyna Dähling, Armin Günther, Leonie Riebandt, Daniel J. Smit, Kristoffer Riecken, Carina Schröder, Ruimeng Zhuang, Till Krech, Malte Kriegs, Boris Fehse, Jakob R. Izbicki, Lutz Fischer, Björn Nashan, Jun Li, Manfred Jücker
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cancers
Subjects:
hepatocellular carcinoma
AKT
mTOR
combined treatment
tumor spheroids
orthotopic mouse model
Online Access:https://www.mdpi.com/2072-6694/14/8/1882

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