Efficient Synthesis of 3‐Mercaptoindoles via HI‐Promoted Sulfenylation of Indoles with Sodium Sulfinates
Abstract A new direct sulfenylation method of indoles by sodium sulfinates and hydroiodic acid was developed giving variety of 3‐sulfenylindoles in high yields under mild conditions without using any catalysts or other additives. In situ‐generated RS‐I species are supposed to be mainly responsible f...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2023-03-01
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| Series: | ChemistryOpen |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/open.202300002 |
| _version_ | 1797859232689684480 |
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| author | Shengnan Sun Hexia Ye Haibo Liu Dr. Yongbiao Guo Zhenhua Gao Dr. Li Pan Dr. Junchen Li Prof. Dr. Xiaojing Bi |
| author_facet | Shengnan Sun Hexia Ye Haibo Liu Dr. Yongbiao Guo Zhenhua Gao Dr. Li Pan Dr. Junchen Li Prof. Dr. Xiaojing Bi |
| author_sort | Shengnan Sun |
| collection | DOAJ |
| description | Abstract A new direct sulfenylation method of indoles by sodium sulfinates and hydroiodic acid was developed giving variety of 3‐sulfenylindoles in high yields under mild conditions without using any catalysts or other additives. In situ‐generated RS‐I species are supposed to be mainly responsible for the key electrophilic alkyl‐ or aryl‐thiolation process. |
| first_indexed | 2024-04-09T21:26:11Z |
| format | Article |
| id | doaj.art-a312ba7b36dc4e38aa2a6cb3c81e0497 |
| institution | Directory Open Access Journal |
| issn | 2191-1363 |
| language | English |
| last_indexed | 2024-04-09T21:26:11Z |
| publishDate | 2023-03-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | ChemistryOpen |
| spelling | doaj.art-a312ba7b36dc4e38aa2a6cb3c81e04972023-03-27T12:44:29ZengWiley-VCHChemistryOpen2191-13632023-03-01123n/an/a10.1002/open.202300002Efficient Synthesis of 3‐Mercaptoindoles via HI‐Promoted Sulfenylation of Indoles with Sodium SulfinatesShengnan Sun0Hexia Ye1Haibo Liu2Dr. Yongbiao Guo3Zhenhua Gao4Dr. Li Pan5Dr. Junchen Li6Prof. Dr. Xiaojing Bi7State Key Laboratory of NBC Protection for Civilian 102205 Beijing ChinaState Key Laboratory of NBC Protection for Civilian 102205 Beijing ChinaState Key Laboratory of NBC Protection for Civilian 102205 Beijing ChinaState Key Laboratory of NBC Protection for Civilian 102205 Beijing ChinaState Key Laboratory of NBC Protection for Civilian 102205 Beijing ChinaState Key Laboratory of NBC Protection for Civilian 102205 Beijing ChinaState Key Laboratory of NBC Protection for Civilian 102205 Beijing ChinaState Key Laboratory of NBC Protection for Civilian 102205 Beijing ChinaAbstract A new direct sulfenylation method of indoles by sodium sulfinates and hydroiodic acid was developed giving variety of 3‐sulfenylindoles in high yields under mild conditions without using any catalysts or other additives. In situ‐generated RS‐I species are supposed to be mainly responsible for the key electrophilic alkyl‐ or aryl‐thiolation process.https://doi.org/10.1002/open.202300002hydroiodic acidindoleregioselectivesodium sulfinate3-sulfenylindoles |
| spellingShingle | Shengnan Sun Hexia Ye Haibo Liu Dr. Yongbiao Guo Zhenhua Gao Dr. Li Pan Dr. Junchen Li Prof. Dr. Xiaojing Bi Efficient Synthesis of 3‐Mercaptoindoles via HI‐Promoted Sulfenylation of Indoles with Sodium Sulfinates ChemistryOpen hydroiodic acid indole regioselective sodium sulfinate 3-sulfenylindoles |
| title | Efficient Synthesis of 3‐Mercaptoindoles via HI‐Promoted Sulfenylation of Indoles with Sodium Sulfinates |
| title_full | Efficient Synthesis of 3‐Mercaptoindoles via HI‐Promoted Sulfenylation of Indoles with Sodium Sulfinates |
| title_fullStr | Efficient Synthesis of 3‐Mercaptoindoles via HI‐Promoted Sulfenylation of Indoles with Sodium Sulfinates |
| title_full_unstemmed | Efficient Synthesis of 3‐Mercaptoindoles via HI‐Promoted Sulfenylation of Indoles with Sodium Sulfinates |
| title_short | Efficient Synthesis of 3‐Mercaptoindoles via HI‐Promoted Sulfenylation of Indoles with Sodium Sulfinates |
| title_sort | efficient synthesis of 3 mercaptoindoles via hi promoted sulfenylation of indoles with sodium sulfinates |
| topic | hydroiodic acid indole regioselective sodium sulfinate 3-sulfenylindoles |
| url | https://doi.org/10.1002/open.202300002 |
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