PPARA intron polymorphism associated with power performance in 30-s anaerobic Wingate Test.
To date, polymorphisms in several genes have been associated with a strength/power performance including alpha 3 actinin, ciliary neurotrophic factor, vitamin D receptor, or angiotensin I converting enzyme, underlining the importance of genetic component of the multifactorial strength/power-related...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4157815?pdf=render |
| _version_ | 1818529227675271168 |
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| author | Miroslav Petr Petr Stastny Ondřej Pecha Michal Šteffl Ondřej Šeda Eva Kohlíková |
| author_facet | Miroslav Petr Petr Stastny Ondřej Pecha Michal Šteffl Ondřej Šeda Eva Kohlíková |
| author_sort | Miroslav Petr |
| collection | DOAJ |
| description | To date, polymorphisms in several genes have been associated with a strength/power performance including alpha 3 actinin, ciliary neurotrophic factor, vitamin D receptor, or angiotensin I converting enzyme, underlining the importance of genetic component of the multifactorial strength/power-related phenotypes. The single nucleotide variation in peroxisome proliferator-activated receptor alpha gene (PPARA) intron 7 G/C (rs4253778; g.46630634G>C) has been repeatedly found to play a significant role in response to different types of physical activity. We investigated the effect of PPARA intron 7 G/C polymorphism specifically on anaerobic power output in a group of 77 elite male Czech ice hockey players (18-36 y). We determined the relative peak power per body weight (Pmax.kg(-1)) and relative peak power per fat free mass (W.kg(-1)FFM) during the 30-second Wingate Test (WT30) on bicycle ergometer (Monark 894E Peak bike, MONARK, Sweden). All WT30s were performed during the hockey season. Overall genotype frequencies were 50.6% GG homozygotes, 40.3% CG heterozygotes, and 9.1% CC homozygotes. We found statistically significant differences in Pmax.kg(-1) and marginally significant differences in Pmax.kg(-1)FFM values in WT30 between carriers and non-carriers for C allele (14.6 ± 0.2 vs. 13.9 ± 0.3 W.kg(-1) and 15.8 ± 0.2 vs. 15.2 ± 0.3 W.kg(-1)FFM, P = 0.036 and 0.12, respectively). Furthermore, Pmax.kg(-1)FFM strongly positively correlated with the body weight only in individuals with GG genotypes (R = 0.55; p<0.001). Our results indicate that PPARA 7C carriers exhibited higher speed strength measures in WT30. We hypothesize that C allele carriers within the cohort of trained individuals may possess a metabolic advantage towards anaerobic metabolism. |
| first_indexed | 2024-12-11T17:04:13Z |
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| id | doaj.art-a31378097249487e9c3bded862c123c6 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T17:04:13Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj.art-a31378097249487e9c3bded862c123c62022-12-22T00:57:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0199e10717110.1371/journal.pone.0107171PPARA intron polymorphism associated with power performance in 30-s anaerobic Wingate Test.Miroslav PetrPetr StastnyOndřej PechaMichal ŠtefflOndřej ŠedaEva KohlíkováTo date, polymorphisms in several genes have been associated with a strength/power performance including alpha 3 actinin, ciliary neurotrophic factor, vitamin D receptor, or angiotensin I converting enzyme, underlining the importance of genetic component of the multifactorial strength/power-related phenotypes. The single nucleotide variation in peroxisome proliferator-activated receptor alpha gene (PPARA) intron 7 G/C (rs4253778; g.46630634G>C) has been repeatedly found to play a significant role in response to different types of physical activity. We investigated the effect of PPARA intron 7 G/C polymorphism specifically on anaerobic power output in a group of 77 elite male Czech ice hockey players (18-36 y). We determined the relative peak power per body weight (Pmax.kg(-1)) and relative peak power per fat free mass (W.kg(-1)FFM) during the 30-second Wingate Test (WT30) on bicycle ergometer (Monark 894E Peak bike, MONARK, Sweden). All WT30s were performed during the hockey season. Overall genotype frequencies were 50.6% GG homozygotes, 40.3% CG heterozygotes, and 9.1% CC homozygotes. We found statistically significant differences in Pmax.kg(-1) and marginally significant differences in Pmax.kg(-1)FFM values in WT30 between carriers and non-carriers for C allele (14.6 ± 0.2 vs. 13.9 ± 0.3 W.kg(-1) and 15.8 ± 0.2 vs. 15.2 ± 0.3 W.kg(-1)FFM, P = 0.036 and 0.12, respectively). Furthermore, Pmax.kg(-1)FFM strongly positively correlated with the body weight only in individuals with GG genotypes (R = 0.55; p<0.001). Our results indicate that PPARA 7C carriers exhibited higher speed strength measures in WT30. We hypothesize that C allele carriers within the cohort of trained individuals may possess a metabolic advantage towards anaerobic metabolism.http://europepmc.org/articles/PMC4157815?pdf=render |
| spellingShingle | Miroslav Petr Petr Stastny Ondřej Pecha Michal Šteffl Ondřej Šeda Eva Kohlíková PPARA intron polymorphism associated with power performance in 30-s anaerobic Wingate Test. PLoS ONE |
| title | PPARA intron polymorphism associated with power performance in 30-s anaerobic Wingate Test. |
| title_full | PPARA intron polymorphism associated with power performance in 30-s anaerobic Wingate Test. |
| title_fullStr | PPARA intron polymorphism associated with power performance in 30-s anaerobic Wingate Test. |
| title_full_unstemmed | PPARA intron polymorphism associated with power performance in 30-s anaerobic Wingate Test. |
| title_short | PPARA intron polymorphism associated with power performance in 30-s anaerobic Wingate Test. |
| title_sort | ppara intron polymorphism associated with power performance in 30 s anaerobic wingate test |
| url | http://europepmc.org/articles/PMC4157815?pdf=render |
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