Clinical and laboratory differences in patients with local and generalized forms of Kaposi sarcoma
The objective: to evaluate clinical and laboratory parameters in local and generalized forms of Kaposi sarcoma (KS) in HIV infected patients to detect predictors of generalized forms of the disease.Subjects and methods. Case histories of 58 HIV infected patients with KS at the age from 28 to 80 year...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2020-09-01
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| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/1451 |
| _version_ | 1797702986608148480 |
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| author | V. D. Renev E. V. Karamov E. I. Veselova O. V. Lovacheva T. E. Tyulkova G. D. Kaminskiy |
| author_facet | V. D. Renev E. V. Karamov E. I. Veselova O. V. Lovacheva T. E. Tyulkova G. D. Kaminskiy |
| author_sort | V. D. Renev |
| collection | DOAJ |
| description | The objective: to evaluate clinical and laboratory parameters in local and generalized forms of Kaposi sarcoma (KS) in HIV infected patients to detect predictors of generalized forms of the disease.Subjects and methods. Case histories of 58 HIV infected patients with KS at the age from 28 to 80 years old were respectively analyzed; they all received treatment in National Medical Research Center of Phthisiopulmonology and Infectious Diseases of the Russian Ministry of Health in 2018-2020. Cases were divided into 2 groups depending on KS manifestations. LF group (local form of KS, n = 28) included the patients with skin lesions; GF group (generalized form of KS, n = 30) included patients with skin lesions and one or several lesions in the other sites: the mucous membrane of gastrointestinal tract, the mucous membrane of tracheobronchial tree, and lung parenchyma.Results. Patients with the generalized form of KS had a higher frequency of skin lesions on the body (pχ2 = 0.036), face (pχ2 = 0.033), and multiple sites (pχ2 = 0.018). Patients from both groups had low CD4+ count, but it was more severe in GF group (pχ2 = 0.027) with a significant increase of the viral load (pχ2 = 0.047). The predictors of the generalized form of KS are the following: the presence of specific lesions on the skin of body, face and multiple localizations, CD4 level below 125 cells/mcL, increase in the viral load above 5.3log10 copies/ml, reduction of erythrocytes level below 3.1 × 1012 cells/L. Among 24 patients with KS who had 4-6 predictors, 19 (79.2%) had the generalized form. Among KS patients with not a single predictor, there were no cases of generalized form, as well as there were no cases of local forms among patients who had 5 and 6 predictors. |
| first_indexed | 2024-03-12T04:57:55Z |
| format | Article |
| id | doaj.art-a31445e25d8446298f21b9527356a6bb |
| institution | Directory Open Access Journal |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| last_indexed | 2024-03-12T04:57:55Z |
| publishDate | 2020-09-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj.art-a31445e25d8446298f21b9527356a6bb2023-09-03T09:14:37ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062020-09-01988394510.21292/2075-1230-2020-98-8-39-451450Clinical and laboratory differences in patients with local and generalized forms of Kaposi sarcomaV. D. Renev0E. V. Karamov1E. I. Veselova2O. V. Lovacheva3T. E. Tyulkova4G. D. Kaminskiy5ФГБУ «Национальный медицинский исследовательский центр фтизиопульмонологии и инфекционных болезней» МЗ РФФГБУ «Национальный медицинский исследовательский центр фтизиопульмонологии и инфекционных болезней» МЗ РФФГБУ «Национальный медицинский исследовательский центр фтизиопульмонологии и инфекционных болезней» МЗ РФФГБУ «Национальный медицинский исследовательский центр фтизиопульмонологии и инфекционных болезней» МЗ РФФГБУ «Национальный медицинский исследовательский центр фтизиопульмонологии и инфекционных болезней» МЗ РФФГБУ «Национальный медицинский исследовательский центр фтизиопульмонологии и инфекционных болезней» МЗ РФThe objective: to evaluate clinical and laboratory parameters in local and generalized forms of Kaposi sarcoma (KS) in HIV infected patients to detect predictors of generalized forms of the disease.Subjects and methods. Case histories of 58 HIV infected patients with KS at the age from 28 to 80 years old were respectively analyzed; they all received treatment in National Medical Research Center of Phthisiopulmonology and Infectious Diseases of the Russian Ministry of Health in 2018-2020. Cases were divided into 2 groups depending on KS manifestations. LF group (local form of KS, n = 28) included the patients with skin lesions; GF group (generalized form of KS, n = 30) included patients with skin lesions and one or several lesions in the other sites: the mucous membrane of gastrointestinal tract, the mucous membrane of tracheobronchial tree, and lung parenchyma.Results. Patients with the generalized form of KS had a higher frequency of skin lesions on the body (pχ2 = 0.036), face (pχ2 = 0.033), and multiple sites (pχ2 = 0.018). Patients from both groups had low CD4+ count, but it was more severe in GF group (pχ2 = 0.027) with a significant increase of the viral load (pχ2 = 0.047). The predictors of the generalized form of KS are the following: the presence of specific lesions on the skin of body, face and multiple localizations, CD4 level below 125 cells/mcL, increase in the viral load above 5.3log10 copies/ml, reduction of erythrocytes level below 3.1 × 1012 cells/L. Among 24 patients with KS who had 4-6 predictors, 19 (79.2%) had the generalized form. Among KS patients with not a single predictor, there were no cases of generalized form, as well as there were no cases of local forms among patients who had 5 and 6 predictors.https://www.tibl-journal.com/jour/article/view/1451вич-инфекциявирус герпеса 8-го типасаркома капошипредикторы прогрессированияcd4-лимфоциты |
| spellingShingle | V. D. Renev E. V. Karamov E. I. Veselova O. V. Lovacheva T. E. Tyulkova G. D. Kaminskiy Clinical and laboratory differences in patients with local and generalized forms of Kaposi sarcoma Туберкулез и болезни лёгких вич-инфекция вирус герпеса 8-го типа саркома капоши предикторы прогрессирования cd4-лимфоциты |
| title | Clinical and laboratory differences in patients with local and generalized forms of Kaposi sarcoma |
| title_full | Clinical and laboratory differences in patients with local and generalized forms of Kaposi sarcoma |
| title_fullStr | Clinical and laboratory differences in patients with local and generalized forms of Kaposi sarcoma |
| title_full_unstemmed | Clinical and laboratory differences in patients with local and generalized forms of Kaposi sarcoma |
| title_short | Clinical and laboratory differences in patients with local and generalized forms of Kaposi sarcoma |
| title_sort | clinical and laboratory differences in patients with local and generalized forms of kaposi sarcoma |
| topic | вич-инфекция вирус герпеса 8-го типа саркома капоши предикторы прогрессирования cd4-лимфоциты |
| url | https://www.tibl-journal.com/jour/article/view/1451 |
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