To a Question on the Mechanism of the Antimicrobial Action of Ortho-Benzoic Sulfimide
The article summarizes and compares data on the properties and biological activity of <i>o</i>-benzoic sulfimide and sulfanilamide compounds. Attention is given to the biochemical conditions under which <i>o-</i>benzoic sulfimide and sulfanilamides have similar activity group...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/13/12/461 |
| _version_ | 1827700134499057664 |
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| author | Ekaterina Y. Kasap Dmitry V. Grishin |
| author_facet | Ekaterina Y. Kasap Dmitry V. Grishin |
| author_sort | Ekaterina Y. Kasap |
| collection | DOAJ |
| description | The article summarizes and compares data on the properties and biological activity of <i>o</i>-benzoic sulfimide and sulfanilamide compounds. Attention is given to the biochemical conditions under which <i>o-</i>benzoic sulfimide and sulfanilamides have similar activity groups. The results of the experimental and theoretical studies aimed at understanding the molecular organization and biological activity of folic acid and its homologous complexes are analyzed. A hypothesis about the possible mechanisms of the formation of such complexes with the participation of <i>o-</i>benzoic sulfimide is presented. The perspectives for the use of <i>o-</i>benzoic sulfimide and its homologues in biomedicine are evaluated. |
| first_indexed | 2024-03-10T14:06:06Z |
| format | Article |
| id | doaj.art-a31565869dbe47ea81e0c97b70190fab |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T14:06:06Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-a31565869dbe47ea81e0c97b70190fab2023-11-21T00:38:46ZengMDPI AGPharmaceuticals1424-82472020-12-01131246110.3390/ph13120461To a Question on the Mechanism of the Antimicrobial Action of Ortho-Benzoic SulfimideEkaterina Y. Kasap0Dmitry V. Grishin1Institute of Biomedical Chemistry (IBMC), Department of Research Laboratories, 119121 Moscow, RussiaInstitute of Biomedical Chemistry (IBMC), Department of Research Laboratories, 119121 Moscow, RussiaThe article summarizes and compares data on the properties and biological activity of <i>o</i>-benzoic sulfimide and sulfanilamide compounds. Attention is given to the biochemical conditions under which <i>o-</i>benzoic sulfimide and sulfanilamides have similar activity groups. The results of the experimental and theoretical studies aimed at understanding the molecular organization and biological activity of folic acid and its homologous complexes are analyzed. A hypothesis about the possible mechanisms of the formation of such complexes with the participation of <i>o-</i>benzoic sulfimide is presented. The perspectives for the use of <i>o-</i>benzoic sulfimide and its homologues in biomedicine are evaluated.https://www.mdpi.com/1424-8247/13/12/461<i>o-</i>benzoic sulfimidesaccharinsulfanilamidefolic acidantimicrobial action |
| spellingShingle | Ekaterina Y. Kasap Dmitry V. Grishin To a Question on the Mechanism of the Antimicrobial Action of Ortho-Benzoic Sulfimide Pharmaceuticals <i>o-</i>benzoic sulfimide saccharin sulfanilamide folic acid antimicrobial action |
| title | To a Question on the Mechanism of the Antimicrobial Action of Ortho-Benzoic Sulfimide |
| title_full | To a Question on the Mechanism of the Antimicrobial Action of Ortho-Benzoic Sulfimide |
| title_fullStr | To a Question on the Mechanism of the Antimicrobial Action of Ortho-Benzoic Sulfimide |
| title_full_unstemmed | To a Question on the Mechanism of the Antimicrobial Action of Ortho-Benzoic Sulfimide |
| title_short | To a Question on the Mechanism of the Antimicrobial Action of Ortho-Benzoic Sulfimide |
| title_sort | to a question on the mechanism of the antimicrobial action of ortho benzoic sulfimide |
| topic | <i>o-</i>benzoic sulfimide saccharin sulfanilamide folic acid antimicrobial action |
| url | https://www.mdpi.com/1424-8247/13/12/461 |
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