Programmed death-ligand 1 expression and overall survival in Thai patients with gastric cancer
Abstract Programmed death-ligand 1 (PD-L1) expression has now been implicated in gastric cancer (GC). This study was conducted to determine the impact of clinicopathological characteristics on PD-L1 expression and its association with survival in GC patients receiving standard-of-care. In total, 268...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-34434-y |
| _version_ | 1797832106149150720 |
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| author | Taned Chitapanarux Pawut Gumrai Sarawut Kongkarnka Komson Wannasai Nirush Lertprasertsuke |
| author_facet | Taned Chitapanarux Pawut Gumrai Sarawut Kongkarnka Komson Wannasai Nirush Lertprasertsuke |
| author_sort | Taned Chitapanarux |
| collection | DOAJ |
| description | Abstract Programmed death-ligand 1 (PD-L1) expression has now been implicated in gastric cancer (GC). This study was conducted to determine the impact of clinicopathological characteristics on PD-L1 expression and its association with survival in GC patients receiving standard-of-care. In total, 268 GC patients receiving upfront surgery were enrolled at Chiang Mai University Hospital. PD-L1 expression was assayed by immunohistochemistry staining using the Dako 22C3 pharmDx. The rates of PD-L1 positivity by combined positive score (CPS) at a cutoff value of 1 and 5 were 22% and 7%. PD-L1 positivity was significantly higher in patients younger than 55 than those older than 55 (32.6% vs. 16.5%, p = 0.003; 11.6% vs. 4.4%, p = 0.027). PD-L1 positivity was observed more frequently in GC with metastases than without (25.2% vs. 17.1%, p = 0.112; 7.2% vs. 6.7%, p = 0.673). Patients with PD-L1 positive had a significantly shorter median overall survival than those with PD-L1 negative (32.7 vs. 41.6 months, p = 0.042, 27.6 vs. 40.8 months, p = 0.038). In conclusion, PD-L1 expression has been associated with young age, short survival, and metastases, although unrelated to the tumor stage. For GC patients, PD-L1 testing is recommended, especially among young patients with metastases. |
| first_indexed | 2024-04-09T14:03:34Z |
| format | Article |
| id | doaj.art-a315c0bf59494b6ca52aa3de48536eef |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T14:03:34Z |
| publishDate | 2023-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a315c0bf59494b6ca52aa3de48536eef2023-05-07T11:11:23ZengNature PortfolioScientific Reports2045-23222023-05-011311710.1038/s41598-023-34434-yProgrammed death-ligand 1 expression and overall survival in Thai patients with gastric cancerTaned Chitapanarux0Pawut Gumrai1Sarawut Kongkarnka2Komson Wannasai3Nirush Lertprasertsuke4Department of Internal Medicine, Faculty of Medicine, Chiang Mai UniversityDepartment of Internal Medicine, Faculty of Medicine, Chiang Mai UniversityDepartment of Pathology, Faculty of Medicine, Chiang Mai UniversityDepartment of Pathology, Faculty of Medicine, Chiang Mai UniversityDepartment of Pathology, Faculty of Medicine, Chiang Mai UniversityAbstract Programmed death-ligand 1 (PD-L1) expression has now been implicated in gastric cancer (GC). This study was conducted to determine the impact of clinicopathological characteristics on PD-L1 expression and its association with survival in GC patients receiving standard-of-care. In total, 268 GC patients receiving upfront surgery were enrolled at Chiang Mai University Hospital. PD-L1 expression was assayed by immunohistochemistry staining using the Dako 22C3 pharmDx. The rates of PD-L1 positivity by combined positive score (CPS) at a cutoff value of 1 and 5 were 22% and 7%. PD-L1 positivity was significantly higher in patients younger than 55 than those older than 55 (32.6% vs. 16.5%, p = 0.003; 11.6% vs. 4.4%, p = 0.027). PD-L1 positivity was observed more frequently in GC with metastases than without (25.2% vs. 17.1%, p = 0.112; 7.2% vs. 6.7%, p = 0.673). Patients with PD-L1 positive had a significantly shorter median overall survival than those with PD-L1 negative (32.7 vs. 41.6 months, p = 0.042, 27.6 vs. 40.8 months, p = 0.038). In conclusion, PD-L1 expression has been associated with young age, short survival, and metastases, although unrelated to the tumor stage. For GC patients, PD-L1 testing is recommended, especially among young patients with metastases.https://doi.org/10.1038/s41598-023-34434-y |
| spellingShingle | Taned Chitapanarux Pawut Gumrai Sarawut Kongkarnka Komson Wannasai Nirush Lertprasertsuke Programmed death-ligand 1 expression and overall survival in Thai patients with gastric cancer Scientific Reports |
| title | Programmed death-ligand 1 expression and overall survival in Thai patients with gastric cancer |
| title_full | Programmed death-ligand 1 expression and overall survival in Thai patients with gastric cancer |
| title_fullStr | Programmed death-ligand 1 expression and overall survival in Thai patients with gastric cancer |
| title_full_unstemmed | Programmed death-ligand 1 expression and overall survival in Thai patients with gastric cancer |
| title_short | Programmed death-ligand 1 expression and overall survival in Thai patients with gastric cancer |
| title_sort | programmed death ligand 1 expression and overall survival in thai patients with gastric cancer |
| url | https://doi.org/10.1038/s41598-023-34434-y |
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