Thyroidal Transcriptomic Profiles of Pathoadaptive Responses to Congenital Hypothyroidism in XB130 Knockout Mice

Thyroidal Transcriptomic Profiles of Pathoadaptive Responses to Congenital Hypothyroidism in XB130 Knockout Mice

Congenital hypothyroidism is a genetic condition in which the thyroid gland fails to produce sufficient thyroid hormone (TH), resulting in metabolic dysfunction and growth retardation. Xb130<sup>−/−</sup> mice exhibit perturbations of thyrocyte cytoskeleton and polarity, and develop post...

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Bibliographic Details
Main Authors: Junichi Sugihara, Aaron Wong, Hiroki Shimizu, Jinbo Zhao, Hae-Ra Cho, Yingchun Wang, Samuel Refetoff, Peter Arvan, Mingyao Liu
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
thyroid hormones
goiter
gene set enrichment analysis
mitochondrial energetics
extracellular matrix
inflammatory response
Online Access:https://www.mdpi.com/2073-4409/11/6/975

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