Concurrent decoding of distinct neurophysiological fingerprints of tremor and bradykinesia in Parkinson’s disease
Parkinson’s disease (PD) is characterized by distinct motor phenomena that are expressed asynchronously. Understanding the neurophysiological correlates of these motor states could facilitate monitoring of disease progression and allow improved assessments of therapeutic efficacy, as well as enable...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2023-05-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/84135 |
| _version_ | 1797805372723953664 |
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| author | Peter M Lauro Shane Lee Daniel E Amaya David D Liu Umer Akbar Wael F Asaad |
| author_facet | Peter M Lauro Shane Lee Daniel E Amaya David D Liu Umer Akbar Wael F Asaad |
| author_sort | Peter M Lauro |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is characterized by distinct motor phenomena that are expressed asynchronously. Understanding the neurophysiological correlates of these motor states could facilitate monitoring of disease progression and allow improved assessments of therapeutic efficacy, as well as enable optimal closed-loop neuromodulation. We examined neural activity in the basal ganglia and cortex of 31 subjects with PD during a quantitative motor task to decode tremor and bradykinesia – two cardinal motor signs of PD – and relatively asymptomatic periods of behavior. Support vector regression analysis of microelectrode and electrocorticography recordings revealed that tremor and bradykinesia had nearly opposite neural signatures, while effective motor control displayed unique, differentiating features. The neurophysiological signatures of these motor states depended on the signal type and location. Cortical decoding generally outperformed subcortical decoding. Within the subthalamic nucleus (STN), tremor and bradykinesia were better decoded from distinct subregions. These results demonstrate how to leverage neurophysiology to more precisely treat PD. |
| first_indexed | 2024-03-13T05:51:05Z |
| format | Article |
| id | doaj.art-a317eaa341dd4c14b5dd2597c2361eb7 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-03-13T05:51:05Z |
| publishDate | 2023-05-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-a317eaa341dd4c14b5dd2597c2361eb72023-06-13T12:50:11ZengeLife Sciences Publications LtdeLife2050-084X2023-05-011210.7554/eLife.84135Concurrent decoding of distinct neurophysiological fingerprints of tremor and bradykinesia in Parkinson’s diseasePeter M Lauro0https://orcid.org/0000-0002-8569-6427Shane Lee1Daniel E Amaya2David D Liu3Umer Akbar4Wael F Asaad5https://orcid.org/0000-0003-4406-9096Department of Neuroscience, Brown University, Providence, United States; Robert J. and Nancy D. Carney Institute for Brain Science, Brown University, Providence, United States; The Warren Alpert Medical School, Brown University, Providence, United StatesDepartment of Neuroscience, Brown University, Providence, United States; Robert J. and Nancy D. Carney Institute for Brain Science, Brown University, Providence, United States; Norman Prince Neurosciences Institute, Rhode Island Hospital, Providence, United States; Department of Neurosurgery, Rhode Island Hospital, Providence, United StatesDepartment of Neuroscience, Brown University, Providence, United States; Robert J. and Nancy D. Carney Institute for Brain Science, Brown University, Providence, United StatesDepartment of Neurosurgery, Brigham and Women’s Hospital, Boston, United StatesRobert J. and Nancy D. Carney Institute for Brain Science, Brown University, Providence, United States; The Warren Alpert Medical School, Brown University, Providence, United States; Norman Prince Neurosciences Institute, Rhode Island Hospital, Providence, United States; Department of Neurology, Rhode Island Hospital, Providence, United StatesDepartment of Neuroscience, Brown University, Providence, United States; Robert J. and Nancy D. Carney Institute for Brain Science, Brown University, Providence, United States; The Warren Alpert Medical School, Brown University, Providence, United States; Norman Prince Neurosciences Institute, Rhode Island Hospital, Providence, United States; Department of Neurosurgery, Rhode Island Hospital, Providence, United StatesParkinson’s disease (PD) is characterized by distinct motor phenomena that are expressed asynchronously. Understanding the neurophysiological correlates of these motor states could facilitate monitoring of disease progression and allow improved assessments of therapeutic efficacy, as well as enable optimal closed-loop neuromodulation. We examined neural activity in the basal ganglia and cortex of 31 subjects with PD during a quantitative motor task to decode tremor and bradykinesia – two cardinal motor signs of PD – and relatively asymptomatic periods of behavior. Support vector regression analysis of microelectrode and electrocorticography recordings revealed that tremor and bradykinesia had nearly opposite neural signatures, while effective motor control displayed unique, differentiating features. The neurophysiological signatures of these motor states depended on the signal type and location. Cortical decoding generally outperformed subcortical decoding. Within the subthalamic nucleus (STN), tremor and bradykinesia were better decoded from distinct subregions. These results demonstrate how to leverage neurophysiology to more precisely treat PD.https://elifesciences.org/articles/84135Parkinson's diseasesubthalamic nucleuselectrocorticographysupport vector regression |
| spellingShingle | Peter M Lauro Shane Lee Daniel E Amaya David D Liu Umer Akbar Wael F Asaad Concurrent decoding of distinct neurophysiological fingerprints of tremor and bradykinesia in Parkinson’s disease eLife Parkinson's disease subthalamic nucleus electrocorticography support vector regression |
| title | Concurrent decoding of distinct neurophysiological fingerprints of tremor and bradykinesia in Parkinson’s disease |
| title_full | Concurrent decoding of distinct neurophysiological fingerprints of tremor and bradykinesia in Parkinson’s disease |
| title_fullStr | Concurrent decoding of distinct neurophysiological fingerprints of tremor and bradykinesia in Parkinson’s disease |
| title_full_unstemmed | Concurrent decoding of distinct neurophysiological fingerprints of tremor and bradykinesia in Parkinson’s disease |
| title_short | Concurrent decoding of distinct neurophysiological fingerprints of tremor and bradykinesia in Parkinson’s disease |
| title_sort | concurrent decoding of distinct neurophysiological fingerprints of tremor and bradykinesia in parkinson s disease |
| topic | Parkinson's disease subthalamic nucleus electrocorticography support vector regression |
| url | https://elifesciences.org/articles/84135 |
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